1995
DOI: 10.1111/j.1476-5381.1995.tb15940.x
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Modulation of the isoprenaline‐induced membrane hyperpolarization of mouse skeletal muscle cells

Abstract: 1 The hyperpolarization of the resting membrane potential, V., induced by isoprenaline in the lumbrical muscle fibres of the mouse, was investigated by use of intracellular microelectrodes.2 In normal Krebs-Henseleit solution (potassium concentration: K+= 5.7 mM, 'control'), V. was -74.0±0.2 mV; lowering K+ to 0.76 mM ('low K'7) resulted in either a hyperpolarization (VM -95.7± 2.9 mV), or a depolarization (Vm= -52.0± 0.3 mV). When Vm hyperpolarized after switching to low K', the addition of isoprenaline resul… Show more

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Cited by 13 publications
(12 citation statements)
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“…The reduced potassium permeability mentioned by Gallant (1983) can be interpreted as the closure of the K IR . Along with our earlier observations (Siegenbeek van Heukelom, 1991, 1994; Van Mil et al 1995), we conclude that our present observations might provide additional insight into hypokalaemic periodic paralysis (Barchi, 1994). At lower temperatures, as is the case in the body extremities, the closure of K IR will be most marked.…”
Section: Discussionsupporting
confidence: 89%
“…The reduced potassium permeability mentioned by Gallant (1983) can be interpreted as the closure of the K IR . Along with our earlier observations (Siegenbeek van Heukelom, 1991, 1994; Van Mil et al 1995), we conclude that our present observations might provide additional insight into hypokalaemic periodic paralysis (Barchi, 1994). At lower temperatures, as is the case in the body extremities, the closure of K IR will be most marked.…”
Section: Discussionsupporting
confidence: 89%
“…The hyperpolarization was associated with small increases in membrane excitability and action potential amplitude that are too small to explain the large force recovery. Activation of β2-adrenergic receptors also leads to Ca V 1.1 channel and ryanodine receptor phosphorylation (Curtis and Catterall, 1985;Suko et al, 1993;Cairns and Borrani, 2015), resulting in greater Ca 2+ release (Cairns et al, 1993;Bruton et al, 1996;Liu et al, 1997;Rudolf et al, 2006;Cairns and Borrani, 2015). It is therefore most likely that most of the force recovery at high K + in the presence of salbutamol is due to greater Ca 2+ release and to a lesser extent to a hyperpolarization (at 0.3 mM Ca 2+ ).…”
Section: Salbutamol Effectsmentioning
confidence: 99%
“…It is well‐documented that catecholamines, β 2 ‐adrenoceptor agonists and/or CGRP induce hyperpolarization in skeletal muscle (Tashiro, 1973; Clausen & Flatman, 1977; Andersen & Clausen, 1993; van Mil et al 1995), cardiac myocytes (Gadsby, 1983; Glitsch et al 1989) and vascular smooth muscle cells (for review, see Standen & Quayle, 1998). In skeletal muscle, this effect has often been attributed to cAMP‐mediated stimulation of the electrogenic Na + ‐K + pump (Clausen & Flatman, 1977; Andersen & Clausen, 1993; Li & Sperelakis, 1993).…”
mentioning
confidence: 99%
“…In heart and smooth muscle, however, the hyperpolarization induced by catecholamines and CGRP is thought to reflect the opening of K + channels, mediated by cyclic AMP (Glitsch et al 1989; Standen & Quayle, 1998). It has been proposed that this is also the mechanism in skeletal muscle (van Mil et al 1995).…”
mentioning
confidence: 99%