Modulation of the lifespan of <i>C. elegans</i> by the controlled release of nitric oxide

Jiang, Dawei; Cheng, Lei; Xue, Yudong; Chen, Chao; Wang, Chaochao; Yang, Guoliang; Xu, An; Yang, Youjun; Gao, Yun

doi:10.1039/c9sc06072c

Cited by 7 publications

(8 citation statements)

References 67 publications

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“…Unfortunately, the high phototoxicity and low tissue penetration of short-wavelength light irradiation greatly limit their biomedical applications. 50 To develop photoNORMs that are responsive to the phototherapeutic window (600−950 nm), the absorption wavelengths of the NO donors can be adjusted by changing the attached antenna moieties. 51 For example, Nakagawa et al synthesized a Si-rhodamine derivative (NORD-1) which can release NO with red irradiation (650− 690 nm).…”

Section: Resultsmentioning

confidence: 99%

“…However, many photoNORMs can mainly respond to UV and near-UV visible light. Unfortunately, the high phototoxicity and low tissue penetration of short-wavelength light irradiation greatly limit their biomedical applications . To develop photoNORMs that are responsive to the phototherapeutic window (600–950 nm), the absorption wavelengths of the NO donors can be adjusted by changing the attached antenna moieties .…”

Section: Resultsmentioning

confidence: 99%

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Red Light-Mediated Photoredox Catalysis Triggers Nitric Oxide Release for Treatment of Cutibacterium Acne Induced Intervertebral Disc Degeneration

et al. 2022

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Intervertebral disc degeneration (IVDD) has been known as a highly prevalent and disabling disease, which is one of the main causes of low back pain and disability. Unfortunately, there is no effective cure to treat this formidable disease, and surgical interventions are typically applied. Herein, we report that the local administration of nitric oxide (NO)releasing micellar nanoparticles can efficiently treat IVDD associated with Modic changes in a rat model established by infection with Cutibacterium acnes (C. acnes). By covalent incorporation of palladium(II) meso-tetraphenyltetrabenzoporphyrin photocatalyst and coumarin-based NO donors into the core of micellar nanoparticles, we demonstrate that the activation of the UV-absorbing coumarin-based NO donors can be achieved under red light irradiation via photoredox catalysis, although it remains a great challenge to implement photoredox catalysis reactions in biological conditions due to the complex microenvironments. Notably, the local delivery of NO can not only efficiently eradicate C. acnes pathogens but also inhibit the inflammatory response and osteoclast differentiation in the intervertebral disc tissues, exerting antibacterial, anti-inflammatory, and antiosteoclastogenesis effects. This work provides a feasible means to efficiently treat IVDD by the local administration of NO signaling molecules without resorting to a surgical approach.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Red Light-Mediated Photoredox Catalysis Triggers Nitric Oxide Release for Treatment of Cutibacterium Acne Induced Intervertebral Disc Degeneration

et al. 2022

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“…The Zhang research group prepared a novel NO donor nanoparticle (PEG-NORM) (Figure 2III,F). 45 Under light conditions, PEG-NORM can release NO and fluorescent reporters, with the released NO concentration depending entirely on the intensity and duration of light exposure (Figure 2III,G). This mechanism enables more effective regulation of biological processes.…”

Section: 8-naphthalimidementioning

confidence: 99%

Section: Bodipymentioning

confidence: 99%

Visible Tracking of Small Molecules of Gases with Fluorescent Donors

Yu,

Xu,

et al. 2024

Chemical & Biomedical Imaging

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Biological gasotransmitters (small molecules of gases) play important roles in signal transduction mechanisms and disease treatments. Although a large number of smallmolecule donors have been developed, visualizing the release of small molecules remains challenging. Owing to their unique optical properties, fluorophores have been widely applied in cellular imaging and tracking. Researchers have used various fluorophores to develop smallmolecule donors with fluorescent activity for visualizing the release of small molecules and their related therapies. These include fluorophores and their derivatives such as borondipyrromethene (BODIPY), coumarin, 1,8-naphthalimide, hemicyanine, porphyrin, rhodamine, and fluorescein. In this review, we summarize the design concepts of functional fluorescent small-molecule donors in terms of different types of fluorophores. Then, we discuss how these donors release small molecules, and the imaging modalities and biomedical applications facilitated by their fluorescent properties. With the systematic discussion of these publications, we hope to provide useful references for the development of more practical, advanced fluorescent small-molecule donors in the future.

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“…As a highly active radical, NO gets involved in various physiological activities, such as vascular growth, immune response, and cell apoptosis. − It is worth noting that NO can exert a protective or destructive effect depending on its concentration, especially in tumor therapy. , Low concentration of NO (nM) could promote tumor cell growth, while a high concentration of NO (>1 μM) could cause DNA damage of tumor cells through generating reactive nitrogen species and act as a message molecule to inhibit tumor metastasis. , NO can distribute more uniformly than drug molecules and more widely than 1 O 2 due to its strong diffusion ability (200 μm in cells) and long lifetime (2 s in cells). , Encouraged by these advantages, the stimuli-responsive NO donors have attracted extensive research interest in recent years. − Various NO donors have been utilized for hypoxic tumor therapy, such as N -diazeniumdiolates and S -nitrosothiols (SNOs). , Although some progress has been made, the practical application of these NO donors still remains challenging due to their poor stability and slow release rate. Therefore, developing stable and easily regulated NO donor is extremely necessary.…”

Section: Introductionmentioning

confidence: 99%

NIR-Triggered On-Demand Nitric Oxide Release for Enhanced Synergistic Phototherapy of Hypoxic Tumor

Zhang

Wang

et al. 2023

Bioconjugate Chem.

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Hypoxia of tumor microenvironments is a major factor restricting tumor treatment, which causes progression and metastasis of tumor. The hypoxic tumor microenvironment not only makes the traditional treatment method, such as chemotherapy, ineffective but also hinders the O2-dependent treatments, such as photodynamic therapy (PDT). Recently, stimuli-responsive nitric oxide (NO) donors have attracted extensive research interest in hypoxic tumor treatment because the NO release process is O2-independent. Besides, NO can distribute more uniformly than drug molecules and more widely than the PDT-generated active species due to its strong diffusion ability (200 μm in cells) and long lifetime (2 s in cells). Encouraged by these advantages, a near infrared light-triggered NO release polymeric nanoplatform (P1-CapNO NPs) was constructed by a thermally sensitive NO release unit, a photothermal unit, and a hydrophilic polyethylene glycol unit. P1-CapNO NPs possess strong absorption in the NIR region (the wavelength of maximal absorption peak was 790 nm with a molar absorption coefficient of 2.4 × 105 M–1 cm–1), great photothermal conversion efficiency (23.8%), and NO release ability (the released NO concentration can reach 1.3 μM) under 808 nm laser irradiation. Owing to these advantages, the great synergistic antitumor effect can be achieved in vitro and in vivo even under the hypoxic environment. The synergistic therapeutic strategy in this work could bypass the obstacles caused by hypoxia in tumor treatment and provide a reference for building a NO-involved therapeutic platform.

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Modulation of the lifespan of C. elegans by the controlled release of nitric oxide

Abstract: The frontier of nitric oxide biology has gradually shifted from mechanism elucidation to biomanipulation, e.g. cell-proliferation promotion, cell-apoptosis induction, and lifespan modulation. This warrants biocompatible nitric oxide (NO) donating materials,...

Cited by 7 publications

References 67 publications

Red Light-Mediated Photoredox Catalysis Triggers Nitric Oxide Release for Treatment of Cutibacterium Acne Induced Intervertebral Disc Degeneration

Red Light-Mediated Photoredox Catalysis Triggers Nitric Oxide Release for Treatment of Cutibacterium Acne Induced Intervertebral Disc Degeneration

Visible Tracking of Small Molecules of Gases with Fluorescent Donors

NIR-Triggered On-Demand Nitric Oxide Release for Enhanced Synergistic Phototherapy of Hypoxic Tumor

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