Modulation of the long terminal repeat promoter activity of small ruminant lentiviruses by steroids

Gómez-Lucı́a, Esperanza; Sanjosé, Leticia; Crespo, Óscar; Reina, Ramsés; Glaria, Idoia; Ballesteros, Natalia; Amorena, B.; Doménech, Ana

doi:10.1016/j.tvjl.2014.08.003

Cited by 5 publications

(7 citation statements)

References 38 publications

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“…The overall tendency that we observed in our study was an inhibitory effect on expression as hormone concentrations increase. 18 This is compatible with the in vivo observation of inhibitory effects (on virus activation) by the highest levels of progesterone during pregnancy, effects that disappeared at parturition when progesterone levels decreased and SRLV was activated. 58…”

Section: The Virus Spreads – and The Body Reactssupporting

confidence: 86%

“…Regarding this latter factor, our group has studied the effect of steroid hormones on the expression of SRLVs, especially prompted by the observation that production and excretion of SRLVs vary with the stage of the sheep or goat reproductive cycle. 18 Steroids act in a similar way to IFN mentioned earlier. They cross cell membranes by simple diffusion due to their lipophilic nature and bind to cytoplasmic receptors.…”

Section: The Virus Spreads – and The Body Reactsmentioning

confidence: 78%

“…The hormone–receptor complexes act as intracellular transcription factors that bind with high affinity to certain TBS called hormone response elements (HREs) present in the DNA ( Figure 5 ). 18 As in the case of IFN, functional HREs have been identified in the LTR of SRLV. The overall tendency that we observed in our study was an inhibitory effect on expression as hormone concentrations increase.…”

Section: The Virus Spreads – and The Body Reactsmentioning

confidence: 98%

“…Proviral DNA is flanked by repeated sequences known as long terminal repeats (LTRs) containing promoter elements that initiate the transcription of DNA 14 and play an important role in cellular tropism 15 – 17 and in pathogenesis. 18 , 19 Gene gag encodes the internal structural proteins, which protect the DNA. The largest is the capsid protein (p25CA), which stimulates the production of antibodies in the host, for which it is used in Enzyme Linked ImmunoSorbent Assay (ELISA) methods.…”

Section: Introductionmentioning

confidence: 99%

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Maedi-Visna virus: current perspectives

Gómez-Lucı́a

Barquero

Doménech

2018

VMRR

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Maedi-Visna virus (MVV) and caprine arthritis-encephalitis virus are commonly known as small ruminant lentiviruses (SRLVs) due to their genetic, structural, and pathogenic similarities. They produce lifelong lasting infections in their hosts, which are characterized by slow progression till overt disease happens. There are four major clinical forms derived from a chronic inflammatory response due to the constant low grade production of viruses from monocyte-derived macrophages: respiratory (caused by interstitial pneumonia), mammary (which may produce a decrease in milk production due to subclinical mastitis), joint (characterized by lameness), and neurological (characterized by chronic nonpurulent meningoencephalomyelitis). There are three levels which try to eliminate the virus: cellular, body, and the flock level. However, SRLVs have ways to counteract these defenses. This review examines some of them.

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Section: The Virus Spreads – and The Body Reactssupporting

confidence: 86%

Section: The Virus Spreads – and The Body Reactsmentioning

confidence: 78%

Section: The Virus Spreads – and The Body Reactsmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Maedi-Visna virus: current perspectives

Gómez-Lucı́a

Barquero

Doménech

2018

VMRR

Self Cite

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“…The reproduction and secretion of virus in MVV infection are affected by the reproductive cycle (lactation, pregnancy, etc.) (Gomez-Lucia et al 2014;Ouzrout and Lerondelle,1990). In this study, the objective was to comparatively analyse through serological and molecular tests the effect of race, gender and lactation on serum apelin levels in fat-tailed sheep belonging to the Red Karaman and White Karaman-Kangal race having different body condition scores (BCS of ≤2, 3-3.5 or ≥4) in terms of MVV infection.…”

Section: Introductionmentioning

confidence: 99%

Investigation of the relationship of apelin hormone response with some physiological parameters in Maedi-Visna infected sheep

Bayraktar

Sait

Takma

et al. 2021

J Hellenic Vet Med Soc

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In this study, the objective was to assess the serological characteristics of sheep, during lactation and pregnancy periods, and rams belonging to the Red Karaman and White Karaman–Kangal race infected with maedi-visna infection and body condition score (BCS) of ≤2, 3- 3.5 and ≥4 (high) and to analyse the relationship between the level of apelin and its secretion. Apelin level in the blood serum samples obtained from the jugular veinof the sheeps was determined using ELISA method. As a result of the analyses, it was determined that the level of apelin was statistically different between the races; between lactating sheep and pregnant sheep; and sheep and rams. There was no difference between the BCS groups (p > 0.05). Race and sex interaction as well as race, sex and BCS triple interaction effects were found significant (p < 0.05). It was observed that the sheep belonging to the White Karaman–Kangal race were 18 times more likely to be infected with the virus. A decrease in apelin level was observed in the sheep with infection, and it was found that the risk of infection was 0.37 times higher in rams than in lactating sheep (p < 0.05).

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In silico analysis of transcription binding site motifs in endogenous and exogenous retroviruses emphasizes their conservation

Gómez-Lucı́a

Ocaña

Benı́tez

et al. 2023

Preprint

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LTRs flanking the proviral genome in retroviruses are functionally divided into three regions: U3, R and U5. Transcription starts in the first nucleotide of the 5’ R and the region just upstream (5’ U3) contains sites which bind cellular factors and trigger transcription, known as TBS. Retroviruses may become endogenous when they infect germ cells, being transmitted throughout generations. In this review we have used the algorithm ALGGEN to analyze the presence of TBS in the U3 region of both endogenous and exogenous retroviruses. Exogenous retroviruses have included different gammaretroviruses (gibbon ape leukemia virus, GALV; murine leukemia virus, MuLV; koala retrovirus, KoRV and feline leukemia virus, FeLV). Endogenous retroviruses studied were related to FeLV (enFeLV). The most abundant TBS found were related to the immune response (adaptive and innate). Many TBS were arranged in clusters combining six or more overlapping sites, and polymorphisms mostly occurred outside the TBS. The number of TBS was similar in most LTRs analyzed. The analysis of TBS may explain the pathogenesis of each viral type. The high degree of conservation of TBS in endogenous sequences supports their importance.

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Modulation of the long terminal repeat promoter activity of small ruminant lentiviruses by steroids

Cited by 5 publications

References 38 publications

Maedi-Visna virus: current perspectives

Maedi-Visna virus: current perspectives

Investigation of the relationship of apelin hormone response with some physiological parameters in Maedi-Visna infected sheep

In silico analysis of transcription binding site motifs in endogenous and exogenous retroviruses emphasizes their conservation

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