Modulation of the Lung Colonization of B16-F1 Melanoma Cells by Citrus Pectin

Abstract

These findings imply that the galactose-containing carbohydrate side chains of CP might mimic or compete with the natural ligand(s) of the tumor galactoside-binding protein (gal-lectin) and thus affect cellular interactions relevant for metastasis.

Plant Pectin: A Potential Source for Cancer Suppression

“…The results showed only 50% of the rats that drank water with MCP (0.1% weight/volume) had any metastases, while 94% of the rats that drank plain water had cancer metastasize to their lungs. Similarly, several animal studies have found that MCP helps reduce the spread of not only prostate cancer but also breast, skin and liver cancer (Nangia-Makker et al, 2002;Platt and Raz, 1992;Liu et al, 2008). MCP was fed to mice with these types of cancer and the mice were found to have a much lower chance of the tumor spreading to the lungs.…”

“…MCP was fed to mice with these types of cancer and the mice were found to have a much lower chance of the tumor spreading to the lungs. In another animal study, the effects of MCP on lung metastasis from melanoma cells were examined (Platt and Raz, 1992). Mice injected with melanoma cells and given MCP were shown to have significantly fewer tumors spread to the lungs compared with mice that did not receive the MCP.…”

“…Mice injected with melanoma cells and given MCP were shown to have significantly fewer tumors spread to the lungs compared with mice that did not receive the MCP. When lung tumors did develop in the mice treated with MCP, the tumors tended to be smaller than those that formed in the untreated mice (Platt and Raz, 1992). In one human study, it was shown that MCP increases the Prostate Specific Antigen (PSA) doubling time (Guess et al, 2003).…”

Oligogalacturonic acid inhibit bone resorption and collagen degradation through its interaction with type I collagen

“…Pectin, a highly complex branched polysaccharides fiber, rich in galactoside residues, is also an important component of human diet. Modified pectins administered orally (16) or intravenously (17) have demonstrated a protective effect against cancer cells. However, the effect of such compounds on bone cells is not yet known.…”

Synergistic Effects of PectaSol-C Modified Citrus Pectin an Inhibitor of Galectin-3 and Paclitaxel on Apoptosis of Human SKOV-3 Ovarian Cancer Cells

“…It is a highly complex branched polysaccharide rich in galactoside residues (Yan and Katz, 2010). CP is water insoluble and is unable to interact with Gal-3, but MCP is water soluble and acts as a ligand for Gal-3, competing with its association to natural ligands (Platt and Raz, 1992;Inohara and Raz, 1994;Pienta et al, 1995) It was reported that Pect-MCP could induce apoptosis and sensitize prostate cancer cells to chemotherapeutic drugs (Wang et al, 2010;Tehranian et al, 2012).…”