Modulation of the Notch System in Response to Wnt Inhibition Induces Restoration of the Rat Luteal Function

Accialini, Paula; Bechis, Andrés; Irusta, Griselda; Bianchi, María S.; Parborell, Fernanda; Abramovich, Dalhia; Tesone, Marta

doi:10.1007/s43032-019-00043-2

Cited by 2 publications

(2 citation statements)

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“…Notably, this work also linked Wnt signaling to the critical process of luteal angiogenesis by demonstrating decreased expression of ovarian VEGF isoforms after Wnt pathway inhibition 27 . Moreover, as further evidence of crosstalk between these important pathways, inhibition of Wnt/β-catenin in vitro in cultured rat corpora lutea stimulated Notch signaling (via an increase in HES expression), suggesting a mechanism by which interactions between the critical Notch and Wnt pathways can promote progesterone signaling 28 .…”

Section: Notch Wnt and Gata Signaling Pathway Interactions Further Regulate Progesteronementioning

confidence: 85%

Updates on molecular and environmental determinants of luteal progesterone production

DeWitt

Whirledge

Kallen

2020

Molecular and Cellular Endocrinology

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Progesterone, a critical hormone in reproduction, is a key sex steroid in the establishment and maintenance of early pregnancy and serves as an intermediary for synthesis of other steroid hormones. Progesterone production from the corpus luteum is a tightly regulated process which is stimulated and maintained by multiple factors, both systemic and local. Multiple regulatory systems, including classic mediators of gonadotropin stimulation such as the cAMP/PKA pathway and TGFβ-mediated signaling pathways, as well as local production of hormonal factors, exist to promote granulosa cell function and physiological fine-tuning of progesterone levels. In this manuscript, we provide an updated narrative review of the known mediators of human luteal progesterone and highlight new observations regarding this important process, focusing on studies published within the last five years. We will also review recent evidence suggesting that this complex system of progesterone production is sensitive to disruption by exogenous environmental chemicals that can mimic or interfere with the activities of endogenous hormones.

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Section: Notch Wnt and Gata Signaling Pathway Interactions Further Regulate Progesteronementioning

confidence: 85%

Updates on molecular and environmental determinants of luteal progesterone production

DeWitt

Whirledge

Kallen

2020

Molecular and Cellular Endocrinology

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“…These pathways affect hair follicle maintenance [22], rhombic pattern formation [23], and somitogenesis in vertebrates [24]. In addition, these pathways have compensatory roles in maintaining the homeostasis of rat luteal cells [25] and are implicated in the proliferation and differentiation of intestinal and embryonic stem cells [26,27].…”

Section: Introductionmentioning

confidence: 99%

Notch2 Regulates the Function of Bovine Follicular Granulosa Cells via the Wnt2/β-Catenin Signaling Pathway

Dang,

Ren,

Chen

et al. 2024

Animals

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Ovarian follicular GCs are strongly implicated in the growth, development, and atresia of ovarian follicles. The Wnt/β-catenin and Notch signaling pathways participate in GC proliferation, differentiation, apoptosis, and steroid hormone production during follicular development. However, the crosstalk between Wnt and Notch signaling in GCs remains unclear. This study investigated this crosstalk and the roles of these pathways in apoptosis, cell cycle progression, cell proliferation, and steroid hormone secretion in bovine follicular GCs. The interaction between β-catenin and Notch2 in GCs was assessed by overexpressing CTNNB1, which encodes β-catenin. The results showed that inhibiting the Notch pathway by Notch2 silencing in GCs arrested the cell cycle, promoted apoptosis, reduced progesterone (P4) production, and inhibited the Wnt2-mediated Wnt/β-catenin pathway in GCs. IWR-1 inhibited Wnt2/β-catenin and Notch signaling, reduced GC proliferation, stimulated apoptosis, induced G1 cell cycle arrest, and reduced P4 production. CTNNB1 overexpression had the opposite effect and increased 17β-estradiol (E2) production and Notch2 protein expression. Co-immunoprecipitation assays revealed that Notch2 interacted with β-catenin. These results elucidate the crosstalk between the Wnt/β-catenin and Notch pathways and the role of these pathways in bovine follicular GC development.

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Modulation of the Notch System in Response to Wnt Inhibition Induces Restoration of the Rat Luteal Function

Cited by 2 publications

References 59 publications

Updates on molecular and environmental determinants of luteal progesterone production

Updates on molecular and environmental determinants of luteal progesterone production

Notch2 Regulates the Function of Bovine Follicular Granulosa Cells via the Wnt2/β-Catenin Signaling Pathway

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