Modulation of the oxygen sensing properties of iridium (III) complexes by changing their substitution groups

Ongun, Merve Zeyrek; Sahin, Murat; Oğuzlar, Sibel; Aytan, Tuğçe Akbal; Topal, Sevinç Zehra; Atílla, Devrim

doi:10.1016/j.ica.2022.121197

Inorganica Chimica Acta

2022

DOI: 10.1016/j.ica.2022.121197

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Modulation of the oxygen sensing properties of iridium (III) complexes by changing their substitution groups

Merve Zeyrek Ongun

Murat Sahin²,

Sibel Oğuzlar³

et al.

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2024

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Cited by 2 publications

References 23 publications

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Mitochondrial Viscosity Probes: Iridium(III) Complexes Induce Apoptosis in HeLa Cells

Chen,

Liang,

Gong

et al. 2024

ChemBioChem

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Mitochondrial viscosity has emerged as a promising biomarker for diseases such as cancer and neurodegenerative disorders, yet accurately measuring viscosity at the subcellular level remains a significant challenge. In this study, we synthesized and characterized three cyclometalated iridium(III) complexes (Ir1‐Ir3) containing 5‐fluorouracil derivatives as ligands. Among these, Ir1 selectively induced apoptosis in HeLa cells by increasing mitochondrial production of reactive oxygen species (ROS), which triggered a cascade of events leading to mitochondrial dysfunction. Additionally, the fluorescence lifetime of Ir1 demonstrated high sensitivity to intracellular viscosity changes, enabling real‐time fluorescence lifetime imaging microscopy (FLIM) of cellular micro‐viscosity during apoptosis. These findings underscore the potential of cyclometalated Ir(III) complexes for both therapeutic and diagnostic applications at the subcellular level.

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Mitochondrial Viscosity Probes: Iridium(III) Complexes Induce Apoptosis in HeLa Cells

Chen,

Liang,

Gong

et al. 2024

ChemBioChem

View full text Add to dashboard Cite

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Iridium(III)‐Incorporating Self‐Healing Polysiloxanes as Materials for Light‐Emitting Oxygen Sensors

Parshina,

Deriabin,

Kolesnikov

et al. 2024

Macromol. Rapid Commun.

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Polymer‐metal complexes (PMCs) based on poly(2,2′‐bipyridine‐4,4′‐dicarboxamide‐co‐polydimethylsiloxanes) with cyclometalated di(2‐phenylpyridinato‐C2,N')iridium(III) fragments and cross‐linked by Zn2+ (Zn[Ir]‐BipyPDMSs) or Ir3+ (Ir[Ir]‐BipyPDMSs) represent flexible, stretchable, phosphorescent, and self‐healing molecular oxygen sensors. PMCs provide strong phosphorescence at λem = 595–605 nm. Zn[Ir]‐BipyPDMS with PDMS chain length of Mn = 5000 has the highest quantum yield of 9.3% and is a molecular oxygen sensor at different O2 concentrations (0–100 vol%) compared to Ir[Ir]‐BipyPDMSs. A Stern−Volmer constant is determined for Zn[Ir]‐BipyPDMS as KSV = 0.014%−1, which is similar to the reported oxygen‐sensitive iridium(III) complexes. All synthesized PMCs exhibit high elongation at break (up to 1100%) and self‐healing efficiency (up to 99%).

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Modulation of the oxygen sensing properties of iridium (III) complexes by changing their substitution groups

Cited by 2 publications

References 23 publications

Mitochondrial Viscosity Probes: Iridium(III) Complexes Induce Apoptosis in HeLa Cells

Mitochondrial Viscosity Probes: Iridium(III) Complexes Induce Apoptosis in HeLa Cells

Iridium(III)‐Incorporating Self‐Healing Polysiloxanes as Materials for Light‐Emitting Oxygen Sensors

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