Modulation of the pattern of axonal projections of a leech motor neuron by ablation or transplantation of its target

Baptista, Carlos; Macagno, Eduardo R.

doi:10.1016/0896-6273(88)90152-3

Cited by 35 publications

(28 citation statements)

References 42 publications

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“…Therefore, a particular branch may be influenced to stop growing and to retract not only by inhibitory factors in its local environment, but also by strong competition from its more vigorously growing siblings. Indeed, in many developing systems, the retraction of some axonal branches has often been seen to be accompanied by growth of other branches (Innocenti, 1981;Stanfield and O'Leary, 1985;Gao and Macagno, 1987a,b;Jellies et al, 1987;Baptista and Macagno, 1988;Callaway and Katz, 1990;Lamantia and Rakic, 1990). Whether the outgrowth of some axonal branches does or does not contribute to the retraction of their sibling branches, however, has not been thoroughly tested experimentally thus far.…”

Section: Abstract: Axonal Retraction; Axonal Outgrowth; Cell-cell Inmentioning

confidence: 99%

“…Several leech neurons, other than the AP cell, trim some of their processes as well (Wallace, 1984;Glover and Mason, 1986;Gao and Macagno, 1987a,b;Jellies et al, 1987;Baptista and Macagno, 1988;Elsas et al, 1995). The selective retraction of some branches generally seems to occur at the same time as sibling branches are maintained or are growing extensively.…”

Section: Competition Among Sibling Branches Contributes To Process Rementioning

confidence: 99%

“…In establishing their particular branching patterns, neurons often generate some neurites that are later retracted (Land and Lund, 1979;Innocenti, 1981;O'Leary et al, 1981;McLoon, 1982;Wallace, 1984;Stanfield and O'Leary, 1985;Glover and Mason, 1986;Gao and Macagno, 1987a,b;Jellies et al, 1987;Baptista and Macagno, 1988;Callaway and Katz, 1990;O'Rourke et al, 1994). Synapse elimination at the neuromuscular junction (Redfern, 1970;Balice-Gordon and Lichtman, 1993) and the segregation of LGN projections to the visual cortex in the formation of ocular dominance column (LeVay et al, 1978(LeVay et al, , 1980 are well known examples of this phenomenon.…”

Section: Abstract: Axonal Retraction; Axonal Outgrowth; Cell-cell Inmentioning

confidence: 99%

“…D, Ablating ipsilateral homologs (X ) results in enhanced growth of the longitudinal projections of an AP cell (ϩ), but a diminution of its lateral arborization (Ϫ). , 1989Baptista and Macagno, 1988). Similarly, horizontal axon collaterals of pyramidal cells in the cat striate cortex do not connect precisely to the appropriate target early during development; instead, selective process elimination occurs later when axon collaterals branch extensively within the target area (Callaway and Katz, 1990).…”

Section: Competition Among Sibling Branches Contributes To Process Rementioning

confidence: 99%

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Competition among the Axonal Projections of an Identified Neuron Contributes to the Retraction of Some of Those Projections

Gan

Macagno

1997

J. Neurosci.

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AP neurons in the embryonic leech CNS extend lateral projections to peripheral targets through the ganglionic nerve roots and longitudinal projections toward neighboring ganglia through the connective nerves. The lateral projections grow extensively in the periphery; in contrast, the longitudinal projections achieve relatively little growth and eventually retract, the majority having essentially disappeared by the end of embryogenesis. Cutting both nerve roots, which eliminates both lateral projections, however, induces the longitudinal projections of the AP neuron to begin to grow rapidly toward adjacent ganglia within 14 hr after the axotomy. By using a laser microbeam to cut just the lateral projections of the AP cells, we further show that it is indeed the loss of its lateral projections, and not a secondary response to the cutting of other components of the root nerves, that induces the longitudinal projections of the AP cell to grow extensively. In addition, we report that reducing the outgrowth of the lateral projections by: (1) cutting only one lateral projection, or (2) ablating pioneer neurons required by the AP neuron to establish its peripheral arbor, also results in a significant increase in the growth of the longitudinal projections. Finally, we demonstrate that increasing the outgrowth of the longitudinal projections by ablating the AP cells in adjacent ganglia results in a significant reduction in the outgrowth of the lateral projections. Taken together, these results indicate, first, that the longitudinal and lateral projections usually grow at the expense of each other, and second, that normally the extensive outgrowth of its lateral projections is a necessary condition for a developing AP neuron to retract its longitudinal projections.

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Section: Abstract: Axonal Retraction; Axonal Outgrowth; Cell-cell Inmentioning

confidence: 99%

Section: Competition Among Sibling Branches Contributes To Process Rementioning

confidence: 99%

Section: Abstract: Axonal Retraction; Axonal Outgrowth; Cell-cell Inmentioning

confidence: 99%

Section: Competition Among Sibling Branches Contributes To Process Rementioning

confidence: 99%

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Competition among the Axonal Projections of an Identified Neuron Contributes to the Retraction of Some of Those Projections

Gan

Macagno

1997

J. Neurosci.

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“…The idea of a competition implies that each of the competing elements has the potential lo be the survivor, given the opportunity to contact the target before the others. Indeed, this has been shown to be the case for the projections of the RPE neurons (Baptista and Macagno, 1988). Consistent with this idea are preliminary results from experiments in which the lateral projections of Ra5,6 cells arc prevented from reaching the periphery.…”

Section: For Some Leech Neurons Direct Interaction With the Target Dmentioning

confidence: 54%

Competition or inhibition? Developmental strategies in the establishment of peripheral projections by leech neurons

Macagno¹,

Gao²,

Baptista³

et al. 1990

J. Neurobiol.

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Leech neurons, like those of other invertebrates and those of vertebrates, undergo specific interactions during development which serve to define their adult morphologies and synaptic connections. We review here several observations and experiments that illustrate these interactions. In particular, we consider how they shape and constrain peripheral arborizations and whether the evidence favors competition or inhibition as their mode of action.

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Cell proliferation in a peripheral target is required for the induction of central neurogenesis in the leech

et al. 1998

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Modulation of the pattern of axonal projections of a leech motor neuron by ablation or transplantation of its target

Cited by 35 publications

References 42 publications

Competition among the Axonal Projections of an Identified Neuron Contributes to the Retraction of Some of Those Projections

Competition among the Axonal Projections of an Identified Neuron Contributes to the Retraction of Some of Those Projections

Competition or inhibition? Developmental strategies in the establishment of peripheral projections by leech neurons

Cell proliferation in a peripheral target is required for the induction of central neurogenesis in the leech

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