Modulation of the release of tachykinins and calcitonin gene-related peptide from peripheral terminals of primary afferent neurons in the guinea-pig lung

Saria, Alois; Humpel, C.; Barthó, L.; Theodorsson‐Norheim, Elvar

doi:10.1016/0167-0115(88)90386-2

Cited by 5 publications

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“…These nerves contain several tachykinins (TKs) such as substance P (SP) and neurokinin A (NKA) and the calcitonin gene-related peptide (CGRP). SP-, TIC-and CGRP-like immunoreactivity was shown to be released by capsaicin from the guinea-pig airways (Saria, Theodorsson-Norheim, Gamse & Lundberg, 1984;Saria, Humpel, Bartho' & Theodorsson-Norheim, 1988a;Saria et al, 1988b;Martling, Saria, Fischer, Hokfelt & Lundberg, 1988). Local release of these sensory neuropeptides determines a variety of motor and inflammatory responses which are thought to be relevant for the pathophysiology of the respiratory tract (Lundberg & Saria, 1987;Barnes, Chung & Page, 1988).…”

Section: Introductionmentioning

confidence: 99%

Immunoblockade by a specific tachykinin antiserum of the non‐cholinergic contractile responses in the guinea‐pig isolated bronchus

Maggi

Patacchini

Baroldi

et al. 1990

Journal of Autonomic Pharmacology

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1. In the guinea-pig isolated bronchus, capsaicin produced a concentration-dependent contraction which was tetrodotoxin- (1 microM) resistant but abolished by previous exposure to capsaicin. 2. Previous incubation with E7 antiserum (which crossreacts with neurokinin A but not with substance P), but not with control rabbit serum, strongly inhibited the contractile response to capsaicin. 3. The E7 antiserum shifted to the right the concentration-response curve to exogenous neurokinin A but not that to substance P. 4. The E7 antiserum also inhibited the non-cholinergic, slowly developing contraction produced by electrical field stimulation (1-5 Hz). 5. These findings provide additional evidence that tachykinin-like peptides play a major role in the bronchoconstrictor response produced by transmitter secretion from peripheral endings of capsaicin-sensitive afferents in guinea-pig bronchi evoked either by capsaicin or by electrical field stimulation.

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Section: Introductionmentioning

confidence: 99%