Modulation of the state of the antiepileptic cerebral system by the influence of a ketogenic diet under conditions of the resistant epileptic syndrome

Abstract

In experiments on rats subjected to a procedure of corazole kindling with the development of antiepileptic drug-resistant seizures, we found that manifestations of resistance were suppressed under conditions of feeding the rats with a ketogenic diet (KD) including 80% lipids and 16.6% proteins. Against the background of using this diet, such means as electrical stimulations of the paleocerebellum, irradiation with extremely high-frequency electromagnetic waves (length 7.1 mm), and administration of L-histidine (300 mg/kg) were more effective from the aspect of inhibition of the above seizure activity. At the same time, keeping rats on the KD modified the action of L-arginine on the epileptic activity to a significantly weaker extent.