Modulation of vertebrate and invertebrate neuromuscular junctions

Worden, Mary Kate

doi:10.1016/s0959-4388(98)80116-5

Cited by 23 publications

(21 citation statements)

References 45 publications

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“…crayfish, crabs, and lobsters) appear to 'tuneup' neural responses systemically for both inhibitory and excitatory neurons. The motor nerve terminals in the periphery and on abdominal muscles, enhance the ability to release more neurotransmitter (Florey and Rathmayer, 1978;Fischer and Florey, 1982;Glusman and Kravitz, 1982;Crider and Cooper, 1990;Delaney et al, 1991;Vyshedskiy et al, 1998;Worden, 1998). The visual system is altered in its sensitivity by migrating pigments (Aréchiga et al, 1990) which may explain phototaxic behaviors (McPhee and Wilkens, 1989).…”

Section: Discussionmentioning

confidence: 99%

Heart rate within male crayfish: social interactions and effects of 5-HT

Listerman

Deskins

Bradacs

et al. 2000

Comparative Biochemistry and Physiology Part A: Molecular &

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Behaviors, such as those that establish dominant and subordinate social status, are thought to be driven by various neuromodulators and hormones. In crustaceans, the level of serotonin (5-HT) in the hemolymph is correlated with degree of aggressiveness. The crustacean heart is neurogenic and is modulated by neural secretion of 5-HT in the hemolymph, which bathes the cardiac tissue. We discuss and present the results of measuring heart rate (HR) of crayfish during interactions, as an indication of their state of excitability. HR is the result of multiple influences: a cocktail of hormones and modulators. HR was monitored during the periods in which crayfish established aggressive and submissive social status, during sham injections, and following injections of various doses of 5-HT. Crayfish, during an interaction to establish social status, can increase HR. Both the aggressive and submissive crayfish can dampen their HR within seconds during a pause in the interaction, while still posturing in an aggressive or submissive state. Injections of 5-HT to obtain systemic levels of approximately 100 nM-10 mM increase HR substantially for hours. This suggests that aggressive interactions and the establishment of a dominant posture may not be related to large increases in the free concentrations of 5-HT within the circulating hemolymph, since a sustained HR is not observed in aggressive animals. Instead, the results may demonstrate that inhibitory cardiac regulation is present in the aggressors during interactions and that a regulator is possibly 5-HT.

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Section: Discussionmentioning

confidence: 99%

Heart rate within male crayfish: social interactions and effects of 5-HT

Listerman

Deskins

Bradacs

et al. 2000

Comparative Biochemistry and Physiology Part A: Molecular &

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show abstract

“…Alternatively or in addition, however, it could also be produced by a direct action of dopamine on the peripheral cardiac musculature. Peripheral effects of modulators, including dopamine, acting both presynaptically at neuromuscular junctions and postsynaptically on the myocytes themselves, are common in other muscles of decapods (e.g., Breen and Atwood 1983;Djokaj et al 2001;Fischer and Florey 1983;Florey and Rathmayer 1978;JorgeRivera et al 1998;Kravitz et al 1980;Lingle 1981), other arthropods, and invertebrates generally (Calabrese 1989;Evans and Myers 1986;Worden 1998). A peripheral dopaminergic action would presumably be attributable to dopamine released neurohormonally from the pericardial organs (dashed arrows in the summary diagram presented in Fig.…”

Section: Cardioactive Actions Of Dopaminementioning

confidence: 99%

Modulation of an Integrated Central Pattern Generator–Effector System: Dopaminergic Regulation of Cardiac Activity in the Blue CrabCallinectes sapidus

Fort

Březina²,

Miller³

2004

Journal of Neurophysiology

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Fort, Timothy J., Vladimir Brezina, and Mark W. Miller. Modulation of an integrated central pattern generator-effector system: dopaminergic regulation of cardiac activity in the blue crab Callinectes sapidus. J Neurophysiol 92: 3455-3470, 2004; doi:10.1152/ jn.00550.2004. Theoretical studies have suggested that the output of a central pattern generator (CPG) must be matched to the properties of its peripheral effector system to ensure production of functional behavior. One way that such matching could be achieved is through coordinated central and peripheral modulation. In this study, morphological and physiological methods were used to examine the sources and actions of dopaminergic modulation in the cardiac system of the blue crab, Callinectes sapidus. Immunohistochemical localization of tyrosine hydroxylase (TH) revealed a prominent neuron in the commissural ganglion, the L-cell, that projected a large-diameter axon to the pericardial organ (PO) by an indirect and circuitous route. Within the PO, the L-cell axon gave rise to fine varicose fibers, suggesting that it releases dopamine in a neurohormonal fashion onto the heart musculature. In addition, one branch of the axon continued beyond the PO to the heart, where it innervated the anterior motor neurons and the posterior pacemaker region of the cardiac ganglion (CG). In physiological experiments, exogenous dopamine produced multiple effects on contraction and motor neuron burst parameters that corresponded to the dual central-peripheral modulation suggested by the L-cell morphology. Interestingly, parameters of the ganglionic motor output were modulated differently in the isolated CG and in a novel semiintact system where the CG remained embedded within the heart musculature. These observations suggest a critical role of feedback from the periphery to the CG and underscore the requirement for integration of peripheral (neurohormonal) actions and direct ganglionic modulation in the regulation of this exceptionally simple system.

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“…We hypothesized that setting the appropriate movement of tentacles for environmental cues by neuronal modulation is important for the optimal accommodation of the whole organism to the environment [101]. Indeed, our study showed that monoamine-(5-HT, DA) and/or neuropeptide-mediated (FMRFa, PACAP) presynaptic facilitation or inhibition provides a mechanism to modulate both large scale and specific tentacle movements.…”

Section: Synaptic Modulation Is Crucial For Spatial and Temporal Collmentioning

confidence: 85%

Anatomical and physiological background permitting spatial odor sensation in stylommatophoran molluscs

Kiss

Krajcs

2016

Acta Biologica Hungarica

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Earlier experiments demonstrated that in order to place protracted tentacles and thereby olfactory receptors in an appropriate position for optimal perception of odor stimuli extraordinary complex movements are required. Until recently both large scale tentacle movements and patterned tentacle movements have been attributed to the concerted involvement of the tentacle retractor muscle and muscles of tegumentum. Recently the existence of three novel muscles in the posterior tentacles of Helix has been discovered. The present review, based on experimental data obtained by our research group, outlines the anatomy, physiology and pharmacology of these muscles that enable the tentacles to execute complex movements observed during foraging both in naïve and food-conditioned snails. Our findings are also compared as far as possible with earlier and recent data obtained on innervation characteristics and pharmacology of molluscan muscles.

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Modulation of vertebrate and invertebrate neuromuscular junctions

Cited by 23 publications

References 45 publications

Heart rate within male crayfish: social interactions and effects of 5-HT

Heart rate within male crayfish: social interactions and effects of 5-HT

Modulation of an Integrated Central Pattern Generator–Effector System: Dopaminergic Regulation of Cardiac Activity in the Blue CrabCallinectes sapidus

Anatomical and physiological background permitting spatial odor sensation in stylommatophoran molluscs

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