Modulation of wheatgrass (Triticum aestivum Linn) toxicity against breast cancer cell lines by simulated microgravity

Al-Awaida, Wajdy; Al-Ameer, Hamzeh J.; Sharab, Ahmad; Akasheh, Rand T.

doi:10.1016/j.crtox.2023.100127

Cited by 5 publications

(2 citation statements)

References 49 publications

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“…Research has demonstrated that microgravity can impact the growth and nutritional value of wheatgrass, a plant known for its high levels of antioxidants like vitamin C. Simulated microgravity conditions have been found to increase wheatgrass's antioxidant activity, the total phenolic content, the total flavonoid content, and its effects on breast cancer cell lines [23]. Wheatgrass grown under microgravity conditions has shown higher levels of vitamin C, which may contribute to its improved antioxidant properties [24].…”

Section: Microgravitymentioning

confidence: 99%

Cultivation of Vitamin C-Rich Vegetables for Space-Radiation Mitigation

Mortazavi,

Yarbaksh,

Zarandi

et al. 2024

Radiation

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Space exploration introduces astronauts to challenges, such as space radiation and microgravity. Researchers have investigated vitamin C as a potential radiation mitigator, as well as antioxidants for sustaining astronaut health. Our own studies demonstrate vitamin C’s life-saving radioprotective effects and its potential as a radiation mitigator, thus highlighting promise, even when administered 24 h post-exposure. This is particularly relevant in scenarios where astronauts may be exposed to sudden large solar particle events, potentially resulting in lethal doses of space radiation. The success of vegetable cultivation on the International Space Station using NASA’s Veggie system offers fresh, vitamin C-rich food. While approved supplements address somatic function, further research is needed to optimize vitamin C’s efficacy in humans, and to develop appropriate antioxidant cocktails for space missions. The variable vitamin C content in vegetables underscores the necessity for the utilization of artificial intelligence (AI) to assist astronauts in selecting and cultivating the vitamin C-rich vegetables best-suited to combat high levels of space radiation and microgravity. Particularly, AI algorithms can be utilized to analyze various factors, such as nutritional content, growth patterns, and cultivation methods. In conclusion, vitamin C shows significant potential for mitigating space radiation, and ongoing research aims to enhance astronaut health through optimal dietary strategies.

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Section: Microgravitymentioning

confidence: 99%

Cultivation of Vitamin C-Rich Vegetables for Space-Radiation Mitigation

Mortazavi,

Yarbaksh,

Zarandi

et al. 2024

Radiation

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“…Plant-based antioxidants may diminish the effects of free radicals, hence reducing oxidative damage. This leads to an increase in defense against illnesses including cancer and coronary heart disease 10 , 11 .…”

Section: Introductionmentioning

confidence: 99%

Synergistic effects of bee venom, hesperidin, and piperine with tamoxifen on apoptotic and angiogenesis biomarker molecules against xerographic MCF-7 injected rats

Khamis,

Ali,

Salim

et al. 2024

Sci Rep

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Breast cancer ranks as the second leading most significant of mortality for women. Studies have demonstrated the potential benefits of natural compounds in cancer treatment and prevention, either in isolation or in conjunction with chemotherapy. In order to improve Tamoxifen's therapeutic efficacy in in-vivo studies, our research sought to determine the effects of hesperidin, piperine, and bee venom as natural compounds, as well as their combination effect with or without Tamoxifen. First, 132 female albino rats were equally divided into six groups and five subgroups, and breast cancer was induced in the selected groups by xenografting of MCF7 cells. Second, the effect of single and best ratio combinations treatment from previous in vitro studies were selected. Next, tumorous mammary glands were collected for apoptotic and antiapoptotic biomarkers and cell cycle analysis. Single or combined natural products with or without Tamoxifen revealed a significant up-regulation in apoptotic genes Bax and Casp3 and a downregulation of antiapoptotic and angiogenesis genes Bcl-2 and VEGF genes. We found that cell cycle arrest in the G0/G1 phase was exclusively caused by Tamoxifen and/ or hesperidin. However, the cell cycle arrest in the G2/M phase is a result of the combination of piperine and bee venom, with or without Tamoxifen by using the flow cytometric technique. Our research concludes that bee venom, hesperidin, and piperine can synergistically enhance to increase Tamoxifen's efficiency in the management of breast cancer.

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Dermaseptin B2 bioactive gene’s potential for anticancer and anti-proliferative effect is linked to the regulation of the BAX/BBC3/AKT pathway

Nasirabadi,

Doosti

2024

Med Oncol

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Modulation of wheatgrass (Triticum aestivum Linn) toxicity against breast cancer cell lines by simulated microgravity

Cited by 5 publications

References 49 publications

Cultivation of Vitamin C-Rich Vegetables for Space-Radiation Mitigation

Cultivation of Vitamin C-Rich Vegetables for Space-Radiation Mitigation

Synergistic effects of bee venom, hesperidin, and piperine with tamoxifen on apoptotic and angiogenesis biomarker molecules against xerographic MCF-7 injected rats

Dermaseptin B2 bioactive gene’s potential for anticancer and anti-proliferative effect is linked to the regulation of the BAX/BBC3/AKT pathway

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