Modulatory action of environmental enrichment on hormonal and behavioral responses induced by chronic stress in rats: Hypothalamic renin-angiotensin system components

Costa, Rafaela; Carvalho, Maeline Santos Morais; Brandão, Juliana Dinéia Perez; Moreira, Roseli Peres; Cunha, Tatiana Sousa; Casarini, Dulce Elena; Marcondes, Fernanda Klein

doi:10.1016/j.bbr.2020.112928

Cited by 12 publications

(12 citation statements)

References 126 publications

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“…Housing adult male rodents in EE for 7 weeks (5 days/week, 2hrs/day), before, during and after exposure to stress, prevented depressive-like behaviors and memory impairments caused by CUMS (Costa et al, 2021). Cordner and Tamashiro reported differences between young and older male mice exposed to stress.…”

Section: Effects Of Ee and Cums On Emotional Behavior And Cognitive F...mentioning

confidence: 97%

“…Concerning the interaction of EE and CUMS, it has been found that 5-week exposure to EE (2 weeks prior and 3 weeks during CUMS) attenuated the increase in serum corticosterone and ACTH levels in adult male rats (Zeeni et al, 2015). Additionally, Costa and colleagues have recently reported that EE housing prior, during and after CUMS reduced epinephrine levels in both stressed and non-stressed male animals and attenuated the secretion of corticosterone and norepinephrine induced by CUMS (Costa et al, 2021).…”

Section: Effects Of Ee and Cums On Brain And Neuroendocrine Function ...mentioning

confidence: 99%

“…Furthermore, EE attenuated stress-associated increases in hypothalamic angiotensin II (peptide hormone that regulates neurophysiology of certain brain regions) (Costa et al, 2021). Interestingly, Muthmainah and colleagues found no difference in plasma corticosterone levels in male rats exposed concurrently to CUMS and EE for 3 weeks, despite increased anxiety in stressed animals (Muthmainah et al, 2021).…”

Section: Effects Of Ee and Cums On Brain And Neuroendocrine Function ...mentioning

confidence: 99%

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Τhe neuroprotective role of environmental enrichment against behavioral, morphological, neuroendocrine and molecular changes following chronic unpredictable mild stress: A systematic review

Dandi

Spandou

Dalla

et al. 2022

Preprint

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Environmental factors interact with biological and genetic factors influencing the development and well-being of an organism. The interest to better understand the role of environment on behavior and physiology led to the development of animal models of environmental manipulations. Environmental Enrichment (EE), an environmental condition that allows cognitive and sensory stimulation as well as social interaction, improves cognitive function, reduces anxiety and depressive-like behavior, and promotes neuroplasticity. In addition, it exerts protection against neurodegenerative disorders, cognitive aging and deficits aggravated by stressful experiences. Given the beneficial effects of EE on brain and behavior, preclinical studies focus on its protective role as an alternative, non-invasive manipulation, to help an organism to cope better with stress. A valid, reliable and effective animal model of chronic stress that enhances anxiety and depression-like behavior is the Chronic Unpredictable Mild Stress (CUMS). The variety of stressors and the unpredictability in the time and sequence of exposure to prevent habituation, render CUMS an ethologically relevant model. CUMS has been associated with dysregulation of the Hypothalamic-Pituitary-Adrenal axis, elevation in the basal levels of stress hormones, reduction in brain volume, dendritic atrophy and alterations in markers of synaptic plasticity. Although numerous studies have underlined the compensatory role of EE against the negative effects of various chronic stress regimens (e.g., restraint, social isolation), research concerning the interaction between EE and CUMS is sparse. The purpose of the current systematic review is to present up-to-date research findings regarding the protective role of EE against the negative effects of CUMS.

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Section: Effects Of Ee and Cums On Emotional Behavior And Cognitive F...mentioning

confidence: 97%

Section: Effects Of Ee and Cums On Brain And Neuroendocrine Function ...mentioning

confidence: 99%

Section: Effects Of Ee and Cums On Brain And Neuroendocrine Function ...mentioning

confidence: 99%

See 1 more Smart Citation

Τhe neuroprotective role of environmental enrichment against behavioral, morphological, neuroendocrine and molecular changes following chronic unpredictable mild stress: A systematic review

Dandi

Spandou

Dalla

et al. 2022

Preprint

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“…AT1 and MAS activation promotes inflammation, cell death, demyelination and alterations in cellular communication, which modifies plasticity and alters the development of cognitive processes. 41 , 43 Microglia activation induces cytokine elevation and neuroinflammation. Additionally, preclinical studies have shown a neuroprotective effect of AT2 agonists after a cerebrovascular accident, and it has been suggested that ECAI or ARBs could help to minimise neuronal damage.…”

Section: Local Renin–angiotensin Systemsmentioning

confidence: 99%

“…The viral S (spike) protein of the SARS-CoV-2 virus (the virus that causes COVID-19) binds to ACE2 as its receptor for host cell entry. 55 This has revealed the participation of the RAS in hyperinflammation processes, a phenomenon that can be a common result in diseases as diverse as digestive, 56 pulmonary, 36 , 38 haematological, 57 , 58 hypothalamic, 41 , 42 neurodegenerative, 43 , 44 bone, 40 reproductive, 59 immunological, 60 , 61 obstetric 62 and cancer diseases. 63 , 64 This further broadens the RAS field and the research on its role in chronic diseases.…”

Section: Ras In the Physiopathology Of Chronic Diseasesmentioning

confidence: 99%