Modulatory Effect of Dietary Inclusion of Aegle marmelos Fruits against Cisplatin - Induced Hepatotoxicity In Wistar Rats

Chandel, Saket Singh; Shirsat, Mrunal K.; Sahu, Ram Kumar; Nayak, Siva S.

doi:10.5604/01.3001.0011.7393

Cited by 7 publications

(6 citation statements)

References 24 publications

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“…These include binding to anionic phospholipids and changing the capacity and structure of cellular and intra-cellular membranes [30], ATP exhaustion from either mitochondrial damage or direct inhibition of mitochondrial oxidative phosphorylation, [31] and it may cause oxidative damage [32]. GM mechanism of nephrotoxicity occurs due to a massive aggregation of the administered gentamicin in the lysosomes [4]. The antioxidant activity of sea cucumbers-saponin (Sc-S) [54] was the reason behind its restoration capacity of the antioxidant system.…”

Section: Discussionmentioning

confidence: 99%

“…[3]. Denamur [4] detailed that aminoglycoside anti-microbials cause intense nephrotoxicity in around 5% to 25% within the patients that have taken it. Additionally, an estimation of the patients who gotten aminoglycoside anti-microbials treatment such as gentamicin for over 7 days of almost 8% to 26%, have demonstrated toxicity within the liver [5].…”

Section: Introductionmentioning

confidence: 99%

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Sea cucumbers-saponin ameliorates hepatorenal toxicity induced by Gentamicin in rats

Mohamed¹,

Gamal²,

El-Zayat³

et al. 2021

GSC Biol. and Pharm. Sci.

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Background: Sea cucumbers have number of one of a pharmacological effects counting anticancer, anticoagulant, anti-inflammatory, antioxidant, and wound healing. Biological properties and therapeutic benefits of Sea cucumbers can be connected to the presence of a wide cluster of bioactive compounds particularly triterpene glycosides (saponins). Aims: The present study aimed to explore the hepatoprotective and nephroprotective activity of Sea cucumbers-saponin (Sc-S) on gentamicin-induced hepatorenal toxicity in rats. Main methods: Eighteen male Wistar rats were divided into three groups, control, gentamycin, and gentamycin+ Sc-S. The hepatorenal toxicity model was induced by gentamycin (80 mg/kg, i.p) for 8 days. Results: The Sc-S group showed a reduction in the concentrations of urea, uric acid, creatinine, MDA and the activities of AST, ALT, and ALP. While it caused a general increase in the levels of CAT and GSH. Microscopic examination appeared a clear enhancement in liver and kidney histology of Sc-S group. Conclusion: The antioxidant activity of Sc-S is the main mechanism for the protection of the liver and kidney against gentamicin toxicity.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Sea cucumbers-saponin ameliorates hepatorenal toxicity induced by Gentamicin in rats

Mohamed¹,

Gamal²,

El-Zayat³

et al. 2021

GSC Biol. and Pharm. Sci.

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“…CP-induced ROS react with cellular macromolecules (nucleic acid, proteins, and lipids), causing extensive liver damage. 1,5 Thus, the combinatorial strategies utilizing phytochemicals with potent antioxidant properties may prove beneficial in the amelioration of CP-induced deleterious hepatic alterations. One such phytochemical is thymoquinone (TQ; 2-isopropyl-5-methyl-1,4-benzoquinone; C 10 H 12 O 2 ; molecular weight: 164.2 g/mol).…”

Section: Introductionmentioning

confidence: 99%

“…CP-induced histopathological aberrations are manifested as inflammatory infiltration, dissolution of hepatic cord, dilated sinusoids, and extensive disorganization of hepatocytes. 4,5 Increasing evidence indicates that CP induces an overwhelmed generation of reactive oxygen species (ROS)/free radicals and depletes endogenous antioxidant reserves leading to a condition known as oxidative stress. CP-induced ROS react with cellular macromolecules (nucleic acid, proteins, and lipids), causing extensive liver damage.…”

Section: Introductionmentioning

confidence: 99%

Thymoquinone supplementation ameliorates cisplatin-induced hepatic pathophysiology

et al. 2021

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Hepatotoxicity is a major dose-limiting side effect of CP chemotherapy besides nephrotoxicity and gastrointestinal dysfunction. TQ, a principal Nigella sativa seed oil constituent, has been shown to improve hepatic functions in various in vivo models of acute hepatic injury. In view of this, the present study aimed to evaluate the effect of TQ against CP-induced hepatotoxicity. Rats were divided into four experimental groups; control, CP, CP+TQ and TQ. Animals in CP+TQ and TQ groups were administered TQ (1.5 mg/kg bwt, orally), with or without a single hepatotoxic dose of CP (6 mg/kg bwt, i.p.) respectively, for 14 days before and four days following the CP treatment. CP induced an upsurge in serum ALT and AST activities, indicating liver injury, as also confirmed by the histopathological findings. CP caused significant alterations in the activities of membrane marker enzymes, carbohydrate metabolic enzymes, and the enzymatic and nonenzymatic components of the antioxidant defense system. TQ supplementation ameliorated all these adverse biochemical and histological changes in CP-treated rats. Thus, TQ may have excellent scope for clinical applications in combating CP-induced hepatic pathophysiology.

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“…It has been expressed that infertility due to oxidative ovary-damage caused by cisplatin would be treated with antioxidant [10]. cisplatin also causes oxidative stress in the lung, liver, stomach and testicle tissues [11][12][13][14]. However, there are not many studies regarding whether cisplatin causes oxidative damage on the bladder, ureter and urethra and with reference to the protective effect of rutin against the cisplatin-induced oxidative damage.…”

Section: Introductionmentioning

confidence: 99%

Effect of rutin on oxidative and proinflammatory damage induced by cisplatin in blood serum, ureter, bladder and urethra in rats

Hirik

Bozkurt

Keskin

et al. 2020

Biotechnology & Biotechnological Equipment

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Rutin (Vitamin P1) is an antioxidant and anti-inflammatory flavonoid. This study examined the effect of rutin on the potential of cisplatin to cause oxidative and proinflammatory damage in blood serum, ureter, bladder and urethra in rats. Animals were divided into four groups: (i) healthy (HG), (ii) 50 mg/kg of rutin þ 5 mg/kg of cisplatin (C þ R50), (iii) 100 mg/kg of rutin þ 5 mg/kg of cisplatin (C þ R100) and (iv) only cisplatin (CG). Rutin and distilled water were applied once a day for eight days. Cisplatin was injected intraperitoneally at a dose of 5 mg/kg for eight days, once every two days. Finally, animals were sacrificed by high-dose anesthesia after blood samples were taken. Ureter, bladder and urethra tissues were removed and malondialdehyde (MDA), myeloperoxidase (MPO), total glutathione (tGSH), superoxide dismutase (SOD) interleukin beta (IL-1b) and tumor necrosis factor alpha (TNF-a) levels were measured. The results showed that the levels of MDA, MPO, IL-1b and TNF-a in the blood serum of the CG group increased significantly (p < 0.0001) and the tGSH and SOD levels decreased compared to the HG. Rutin administration reversed the effect as seen in C þ R50 and C þ R100 groups. However, there was no statistically significant difference in the levels of MDA, MPO, tGSH, SOD, IL-1b and TNF-a in ureter, bladder and urethra tissue (p > 0.05).This suggests that cisplatin produces oxidative stress in the blood serum but not in the ureter, bladder and urethra tissues. It was observed that rutin prevented the cisplatin-related oxidative and proinflammatory damage in the blood serum.

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Modulatory Effect of Dietary Inclusion of Aegle marmelos Fruits against Cisplatin - Induced Hepatotoxicity In Wistar Rats

Abstract: We can conclude that the hepatoprotective activity of Aegle marmelos was due to its antioxidant effect as evidenced by increasing activity of antioxidant enzymes with enhanced hepatic function and significantly changed the physiological parameters.

Cited by 7 publications

References 24 publications

Sea cucumbers-saponin ameliorates hepatorenal toxicity induced by Gentamicin in rats

Sea cucumbers-saponin ameliorates hepatorenal toxicity induced by Gentamicin in rats

Thymoquinone supplementation ameliorates cisplatin-induced hepatic pathophysiology

Effect of rutin on oxidative and proinflammatory damage induced by cisplatin in blood serum, ureter, bladder and urethra in rats

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