Modulatory Effect of <i>Byrsonima basiloba</i> Extracts on the Mutagenicity of Certain Direct and Indirect-Acting Mutagens in <i>Salmonella typhimurium</i> Assays

Lira, Walclecio de Moraes; Santos, Fábio V.; Sannomiya, Míriam; Rodrigues, Clenilson Martins; Vilegas, Wagner; Varanda, Eliana Aparecida

doi:10.1089/jmf.2007.553

Cited by 40 publications

(45 citation statements)

References 41 publications

(43 reference statements)

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“…It is known that mutations are a major factor for the onset of cancer. However, chemoprevention, that is the prevention of cancer development by chemical substances that act as antimutagenic agents, with the capacity to interact with mutagenic compounds or their metabolites and reduce their effects, is one possible way to prevent cancer (Nogueira et al, 2006;Lira et al, 2008;Chen et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Assessment of estrogenic, mutagenic and antimutagenic activity of nemorosone

Camargo¹,

Varela²,

Oliveira³

et al. 2011

Rev. bras. farmacogn.

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Currently, a wide range of research involving natural products is focused on the discovery of new drugs in many different therapeutic areas. A great number of the synthetic compounds on the market were derived from natural products, especially plants. Nemorosone is the major constituent of the floral resin of Clusia rosea Jacq., Clusiaceae, and in Cuban propolis. In vitro studies have shown cytotoxic activity in this substance against various tumor cell lines, including those resistant to various cytotoxic drugs, whereas it has low cytotoxicity to non-tumoral cells. Therefore, in order to characterize the biological activity of nemorosone, a substance with potential antitumor activity, and in view of preclinical testing of the toxicity of drug candidate compounds, the main aim of this study was to determine the mutagenic and antimutagenic activity of nemorosone by the Ames test, using the strains TA97a, TA98, TA100 and TA102 of Salmonella typhimurium. Secondly, to characterize the estrogenic activity in an experimental recombinant yeast model (Recombinant Yeast Assay) mutagenic activity was observed at in any of the concentrations in any of the test strains. To evaluate the antimutagenic potential, direct and indirect mutagenic agents were used: 4 nitro-o-phenylenediamine (NPD), mitomycin C (MMC) and aflatoxin B1 (AFL). Nemorosone showed moderate antimutagenic activity (inhibition level 31%), in strain TA100 in the presence of AFL, and strong antimutagenic activity in TA102 against MMC (inhibition level 53%). Estrogenic activity was observed, with an EEq of 0.41±0.16 nM at various tested concentrations.

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Section: Introductionmentioning

confidence: 99%

Assessment of estrogenic, mutagenic and antimutagenic activity of nemorosone

Camargo¹,

Varela²,

Oliveira³

et al. 2011

Rev. bras. farmacogn.

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“…The phytochemical investigation of the leaves and stems afforded the flavonoids (+)-catechin, (-)-epicatechin, quercitrin and isoquercitrin, which are frequently found in Byrsonima species including B. basiloba, 6,7 B. bucidaefolia, 8 B. crassa, 9,10 B. crassifolia, [11][12][13][14] B. fagifolia, [15][16][17] B. intermedia, 18 B. microphylla, 19,20 and B. verbascifolia; 21,22 the investigation also afforded the tannins 3,5-di-O-galloylquinic acid, 5-O-galloylquinic acid, 5-O-(3-methylgalloyl)-quinic acid, 3,4,5-tri-O-galloylquinic acid and gallic acid, which have been previously described in B. crassa 9,10 and B. fagifolia. [15][16][17] Among the compounds isolated from the stems of B. coccolobifolia, (+)-syringaresinol and trigonostemone are new in the genus Byrsonima.…”

Section: Resultsmentioning

confidence: 99%

“…[3][4][5] The compounds most commonly isolated from this genus are flavonoids, terpenes, gallic acids and quinic acid derivatives. 1 Among the constituents, flavonoids (flavanones, bioflavonoids, flavonols and procyanidins), triterpenes (with oleanolic and ursolic skeletons) and modified triterpenoids (steroids) are commonly found in B. basiloba, 6,7 B. bucidaefolia, 8 B. crassa, 9,10 B. crassifolia, [11][12][13][14] B. fagifolia, [15][16][17] B. intermedia, 18 B. microphylla, 19,20 and B. verbascifolia. 21,22 Previous studies on the leaves of B. coccolobifolia revealed the presence of flavonoids, gallic acid and xanthones.…”

Section: Introductionmentioning

confidence: 99%

“…4,5 EXPERIMENTAL SECTION General experimental procedures 1 H-NMR and 2D NMR spectra were obtained on a Bruker model ARX 100 MHz and DRX-400 NMR spectrometer. Me 4 Si was used as an internal standard (J in Hz), and CDCl 3 , CD 3 OD and DMSO-d 6 were used as solvents. MS spectra (m/z) were acquired using a Bruker Daltonics, Micromass TOF -Q II -ESI -TOF, high-resolution mass spectrometer.…”

Section: Introductionmentioning

confidence: 99%

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NEW DEGRADED QUINONE DITERPENOID FROM THE STEMS OF Byrsonima coccolobifolia Kunth. (Malpighiaceae)

et al. 2017

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A chemical investigation of two specimens of Byrsonima coccolobifolia collected in the southeast cerrado and from central Brazil was performed. A new degraded diterpenoid, byrsonimaquinone, was isolated from the stems along with known compounds. This is the first study on the roots of B. coccolobifolia, and several triterpenes, such as α-amyrin, β-amyrin, oleanolic acid, and glochidonol, along with a mixture of stigmasterol, β-sitosterol and campesterol, were identified. These compounds were identified by spectroscopic analysis techniques, including 1D and 2D NMR, GC-MS and high-resolution mass spectrometry.

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“…Leaves and trunk barks from various species the Byrsonima are popularly employed in folk medicine to treat fever, gastrointestinal dysfunction (diarrhea and gastric ulcer), asthma, skin infections, and snakebites (Lira et al 2008, Mendes et al 1999 PATRÍCIA A. RODRIGUES et al al. 1999, Martínez-Vázquez et al 1999, bioactivity studies have demonstrated the gastroprotective, healing and antidiarrheal activities of B. fagifolia , the antimutagenic activity of B. basiloba (Lira et al 2008), and the mutagenic and gastroprotective effects of Byrsonima crassa (Cardoso et al 2006, Sannomiya et al 2007.…”

Section: Introductionmentioning

confidence: 99%

Gastroprotective effect of Byrsonima sericea DC leaf extract against ethanol-induced gastric injury and its possible mechanisms of action

Rodrigues¹,

Morais²,

Souza³

et al. 2012

An. Acad. Bras. Ciênc.

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Byrsonima sericea leaves are extensively used in folk medicine in Brazil against gastric disorders. This study investigated the chemical constituents of B. sericea leaf ethanolic extract (BSLE) and its potential gastroprotective activity, with its possible mechanism of the action using ethanol to induce gastric mucosal damage in mice. The phytochemical analysis was carried out to identify the active constituents present in the extract, and the HPLC analysis was performed for the identification of flavonoids. BSLE at oral doses of 125, 250 and 500 mg/kg markedly attenuated the ethanol-evoked gastric lesions by 53.2, 84.9 and 87.6 %, respectively. The BSLE (250 mg/kg) prevented the depletion of gastric mucus and gastric mucosal nonproteic-sulfhydryl groups, SOD and CAT, as well as the increase in the MDA content promoted by absolute ethanol. Moreover, the effect of BSLE against ethanol damage was found to be significantly reduced in mice pretreated with Capsazepine (i.p.), L-NAME (i.p.) or glibenclamide (i.p.), the respective blockers/inhibitors of TRPV1, NO synthase and K+ATP channel. The phytochemical investigation on BSLE revealed the presence of flavonoids rutin, isoquercitrin, kaempferol 3-O-rutinoside and quercetin, which are compounds well known for their antioxidant and gastroprotective properties. These results suggest that BSLE affords gastroprotection through multiple mechanisms, which may be helpful in the treatment of pathologies associated with gastric dysfunctions.

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Modulatory Effect of Byrsonima basiloba Extracts on the Mutagenicity of Certain Direct and Indirect-Acting Mutagens in Salmonella typhimurium Assays

Cited by 40 publications

References 41 publications

Assessment of estrogenic, mutagenic and antimutagenic activity of nemorosone

Assessment of estrogenic, mutagenic and antimutagenic activity of nemorosone

NEW DEGRADED QUINONE DITERPENOID FROM THE STEMS OF Byrsonima coccolobifolia Kunth. (Malpighiaceae)

Gastroprotective effect of Byrsonima sericea DC leaf extract against ethanol-induced gastric injury and its possible mechanisms of action

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