Modulatory effect of pomegranate extract on TRPA1, TRPM2 and caspase-3 expressions in colorectal cancer induction of mice

Kaya, İnan; Dağ, Serpil; Kaya, Müge Mavioğlu; Tanrıverdi, Erdi Anil; Beşeren, Hatice; Aşasın, Gizem

doi:10.1515/tjb-2022-0099

Cited by 2 publications

(1 citation statement)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous studies measured high expression levels of TRPA1 and TRPM2 in mice with induced CRC and a direct relationship with expression levels of TNF-α and Casp-3 [120]. Therefore, the authors propose pomegranate extract as modulator of these proteins.…”

Section: Redox Trp Channels and Inflammationmentioning

confidence: 95%

TRP Channels in Tumoral Processes Mediated by Oxidative Stress and Inflammation

Piciu,

Balas,

Badea

et al. 2023

Antioxidants

View full text Add to dashboard Cite

The channels from the superfamily of transient receptor potential (TRP) activated by reactive oxygen species (ROS) can be defined as redox channels. Those with the best exposure of the cysteine residues and, hence, the most sensitive to oxidative stress are TRPC4, TRPC5, TRPV1, TRPV4, and TRPA1, while others, such as TRPC3, TRPM2, and TRPM7, are indirectly activated by ROS. Furthermore, activation by ROS has different effects on the tumorigenic process: some TRP channels may, upon activation, stimulate proliferation, apoptosis, or migration of cancer cells, while others inhibit these processes, depending on the cancer type, tumoral microenvironment, and, finally, on the methods used for evaluation. Therefore, using these polymodal proteins as therapeutic targets is still an unmet need, despite their draggability and modulation by simple and mostly unharmful compounds. This review intended to create some cellular models of the interaction between oxidative stress, TRP channels, and inflammation. Although somewhat crosstalk between the three actors was rather theoretical, we intended to gather the recently published data and proposed pathways of cancer inhibition using modulators of TRP proteins, hoping that the experimental data corroborated clinical information may finally bring the results from the bench to the bedside.

show abstract

Section: Redox Trp Channels and Inflammationmentioning

confidence: 95%

TRP Channels in Tumoral Processes Mediated by Oxidative Stress and Inflammation

Piciu,

Balas,

Badea

et al. 2023

Antioxidants

View full text Add to dashboard Cite

show abstract

TRP Channels in Tumoral Processes Mediated by Oxidative Stress and Inflammation: Friends or Foes?

Piciu,

Balas,

Badea

et al. 2023

Preprint

View full text Add to dashboard Cite

The channels from the superfamily of transient receptor potential (TRP) activated by reactive oxygen species (ROS) are defined as redox channels. Those with the best exposure of the cysteine residues and hence the most sensitive to oxidative stress are TRPC4, TRPC5, TRPV1, TRPV4, and TRPA1, while others, such as TRPM2 and TRPM7 are indirectly activated by ROS. Activation by ROS has different effects on the tumorigenic process: some TRP channels may, upon activation, stimulate proliferation, apoptosis, or migration of cancer cells, while others inhibit these processes, depending on the cancer type, tumoral microenvironment and finally on the methods used for evaluation. Therefore, the use of these polymodal proteins as therapeutic targets is still an unmet need, despite their draggability and modulation by simple and mostly unharmful compounds. In this review, we intend to create some cellular models of the interaction between oxidative stress, TRP channels, and inflammation. Although the crosstalk between the three actors is rather theoretical, we intended to gather the recently published data and proposed pathways of cancer inhibition using modulators of TRP proteins, hoping that the experimental data corroborated with clinical information may finally bring the results from the bench to the bedside.

show abstract

Modulatory effect of pomegranate extract on TRPA1, TRPM2 and caspase-3 expressions in colorectal cancer induction of mice

Cited by 2 publications

References 34 publications

TRP Channels in Tumoral Processes Mediated by Oxidative Stress and Inflammation

TRP Channels in Tumoral Processes Mediated by Oxidative Stress and Inflammation

TRP Channels in Tumoral Processes Mediated by Oxidative Stress and Inflammation: Friends or Foes?

Contact Info

Product

Resources

About