Modulatory effect ofOvothiol‐Aon myocardial infarction induced by epinephrine in rats

Abstract

Myocardial infarction (MI) is one of the most prevalent disorders seen in clinical practice, and its prevalence has risen dramatically in the last decade. Ovothiol‐A is a natural product isolated from sea urchin eggs and display unusual antioxidant properties. The present study investigates the therapeutic effect of Ovothiol‐A against MI stimulated in rats by epinephrine injection. Subcutaneous injection of 2 mg/kg epinephrine for 2 days caused MI in rats. The rats divided into three groups; control, MI, and MI treated with Ovothiol‐A (500 mg/kg, orally) for 7 days. The treatment with Ovothiol‐A restored ST‐segment near normal, ameliorated the changes in cardiac troponin T, creatine kinase, lactate dehydrogenase, aspartate aminotransferase, alanine amino transferase, alkaline phosphatase, total proteins, creatinine, uric acid, urea, malondialdehyde, nitric oxide, reduced glutathione, catalase, glutathione‐S‐transferase, hemoglobin, RBCs, WBCs, platelet/lymphocyte ratio, and neutrophil/lymphocyte ratio. The histological investigation revealed that Ovothiol‐A‐treated group showed marked improvement in the examined cardiac muscles, liver and kidney in numerous sections. Ovothiol‐A possessed a therapeutic effect against epinephrine‐induced myocardial infarction. Ovothiol‐A improves cardiac, liver, and kidney biomarkers and restores the typical pattern of EEG. Practical applications Eggs of sea urchins are rich in potent antioxidant molecule (Ovothiol‐A). The current study reveals the ability to use Ovothiol‐A in the treatment of myocardial infarction.