2014
DOI: 10.1152/jn.00730.2013
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Modulatory effects of activation of metabotropic glutamate receptors on GABAergic circuits in the mouse cortex

Abstract: Liu T, Petrof I, Sherman SM. Modulatory effects of activation of metabotropic glutamate receptors on GABAergic circuits in the mouse cortex. J Neurophysiol 111: 2287-2297, 2014. First published March 12, 2014 doi:10.1152/jn.00730.2013.-Metabotropic glutamate receptors (mGluRs) have a ubiquitous distribution in the central nervous system and often serve to regulate the release of neurotransmitters. We have previously shown that activation of both presynaptic and postsynaptic mGluRs can affect the gain of gluta… Show more

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Cited by 13 publications
(7 citation statements)
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References 45 publications
(57 reference statements)
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“…Examples of such modulation by class 2 inputs include control of tonic versus burst firing mode of thalamic relay cells (29,30) and affecting the EPSP amplitudes of class 1 inputs (1,(31)(32)(33)(34)(35). Also consistent with this modulatory role for class 2 inputs are in vivo studies showing that optogenetic manipulation of the class 2 corticogeniculate pathway from cortical layer 6 shows that gain control is one of its main roles (36,37).…”
Section: Discussionmentioning
confidence: 80%
“…Examples of such modulation by class 2 inputs include control of tonic versus burst firing mode of thalamic relay cells (29,30) and affecting the EPSP amplitudes of class 1 inputs (1,(31)(32)(33)(34)(35). Also consistent with this modulatory role for class 2 inputs are in vivo studies showing that optogenetic manipulation of the class 2 corticogeniculate pathway from cortical layer 6 shows that gain control is one of its main roles (36,37).…”
Section: Discussionmentioning
confidence: 80%
“…A perhaps surprising source of inhibition and disinhibition is glutamate. By activating pre- and postsynaptic metabotropic receptors in various neocortical circuits, glutamate release can induce suppression of GABA release and inhibition of L4 neurons, respectively ( Liu et al, 2014 ; Lee and Sherman, 2009 ). Thus, multiple, partially overlapping ( Gonchar et al, 2007 ) sources of inhibition may be differentially recruited depending on context, providing a multilayered control of cortical function ( Kepecs and Fishell, 2014 ; Pakan et al, 2016 ).…”
Section: Discussionmentioning
confidence: 99%
“…Evidence indeed exists that activation of modulatory glutamatergic inputs can affect the gain of driver inputs to neurons and also affect firing mode of thalamic relay cells (Godwin et al ., ; DePasquale & Sherman, ; Lam & Sherman, ; Liu et al ., , ). As noted above, other evidence indicates that the layer 6 corticothalamic pathway controls the gain of thalamocortical responsiveness (Lee & Sherman, , ; DePasquale & Sherman, ).…”
Section: Drivers and Modulatorsmentioning
confidence: 99%