Modulatory effects of dopamine receptors on associative learning performance in zebrafish (Danio rerio)

Naderi, Mohammad; Jamwal, Ankur; Chivers, Douglas P.; Niyogi, Som

doi:10.1016/j.bbr.2016.01.034

Cited by 40 publications

(38 citation statements)

References 97 publications

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“…In their native environment, the dopamine reward system might allow damselfish to recognize a beneficial reef or location such as their territory, profitable food source, or location of receptive mates for reproduction and encode this information for future use. These results support recent studies demonstrating a modulatory influence of dopamine on associative learning [15] and latent learning [24] in zebrafish, and learning decision-making tasks in cleaner wrasses [2]. Our results demonstrate that under these experimental conditions damselfish can develop object recognition memory for at least a 10-min span after D 1 agonist treatment.…”

Section: Discussionsupporting

confidence: 92%

“…D 1 and D 2 receptors have been reported in zebrafish [6,7], and the dopaminergic system is known to partially regulate reward, motivation, sociality and response to novelty in teleost fish [8][9][10][11][12][13][14]. Additionally, the administration of D 1 receptor agonists has recently been shown to enhance learning based tasks in cleaner wrasse (Labroides Dimidiatus) [2] and zebrafish [15].…”

Section: Introductionmentioning

confidence: 99%

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Dopamine D1 receptor activation leads to object recognition memory in a coral reef fish

2017

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Object recognition memory is the ability to identify previously seen objects and is an adaptive mechanism that increases survival for many species throughout the animal kingdom. Previously believed to be possessed by only the highest order mammals, it is now becoming clear that fish are also capable of this type of memory formation. Similar to the mammalian hippocampus, the dorsolateral pallium regulates distinct memory processes and is modulated by neurotransmitters such as dopamine. Caribbean bicolour damselfish () live in complex environments dominated by coral reef structures and thus likely possess many types of complex memory abilities including object recognition. This study used a novel object recognition test in which fish were first presented two identical objects, then after a retention interval of 10 min with no objects, the fish were presented with a novel object and one of the objects they had previously encountered in the first trial. We demonstrate that the dopamine D-receptor agonist (SKF 38393) induces the formation of object recognition memories in these fish. Thus, our results suggest that dopamine-receptor mediated enhancement of spatial memory formation in fish represents an evolutionarily conserved mechanism in vertebrates.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Dopamine D1 receptor activation leads to object recognition memory in a coral reef fish

2017

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“…DA plays a significant role in cognition and motor movement, so disruptions in the normal ontogeny of the DA system during critical windows of CNS development are expected to alter behavior. Modulation of the DA system, for example, impacts ZF learning and memory, illustrated through the application of different agonists and antagonists . Apomorphine, a nonselective DA agonist, impairs acquisition and consolidation of latent learning in ZF, characterized by prolonged latency to leave the start chamber, increased dwelling time in incorrect tunnels, and latency in reaching reward chambers .…”

Section: Discussionmentioning

confidence: 99%

“…Modulation of the DA system, for example, impacts ZF learning and memory, illustrated through the application of different agonists and antagonists. 18,42 Apomorphine, a nonselective DA agonist, impairs acquisition and consolidation of latent learning in ZF, characterized by prolonged latency to leave the start chamber, increased dwelling time in incorrect tunnels, and latency in reaching reward chambers. 18 In the assay used here, zebrafish larvae become hyperactive in the dark following light stimulation (dark photokinesis) and exhibit nondirectional light-seeking behavior proposed to be related to hunting for food and predator avoidance.…”

Section: Dmp Induces Hyperactivity In Zebrafish Larvaementioning

confidence: 99%

Domperidone upregulates dopamine receptor expression and stimulates locomotor activity in larval zebrafish (Danio rerio)

Shontz

Souders

Schmidt

et al. 2018

Genes Brain and Behavior

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Dopamine (DA) plays a significant role in cognition, motor function and social behavior. The objectives of this study were to (1) quantify the temporal expression of transcripts (DA receptors, transporters and tyrosine hydroxylase) associated with DA signaling during early stages of zebrafish development and (2) determine their expression profiles following treatment with a D receptor antagonist domperidone (DMP). We also assessed locomotor behavior following treatment with DMP using alternating periods of light and dark (ie, dark photokinesis), as DA plays a key role in behavior. Relative expression levels of transcripts that were investigated and related to the DA system were detected after the first 24 hours postfertilization (hpf). Some DA receptor transcripts (eg, drd4c) increased in abundance earlier in the embryo compared with other receptors (eg, drd3), suggesting that DA receptor paralogs may have unique roles in development. Treatment of larvae with DMP resulted in the upregulation of DA receptor transcripts (ie, drd1, drd7, drd4b, drd4c) and DA transporter 1 (ie, slc6a3), and it is hypothesized that upregulation of genes related to the DA system is a compensatory neurophysiological response to DA receptor antagonism. Larval activity during dark photokinesis (measured by distance traveled) was also elevated by DMP. We hypothesize that behavioral responses observed with DMP may be related to the regulation of deep brain photoreception in zebrafish (Danio rerio) (ZF) larvae by DA.

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“…Among the different types of dopaminergic receptors, the excitatory D1 receptor (D1-R) subtype is the most predominately expressed in the brain regions [49]. D1-R activate the production of intracellular 3’-5’-cyclic adenosine monophosphate (cAMP) through adenylyl cyclase induction and regulate intercellular calcium signaling or protein kinase activity [50].…”

Section: Discussionmentioning

confidence: 99%

Social interaction influences innate color preference of zebrafish shoals

Wang

Liang

et al. 2020

Preprint

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9The color discrimination can confer survival advantages by helping 10 animals to find nutritious food and shelter and to avoid predator. 11Zebrafish as a social species, data on innate color preference in shoals 12 remain controversial and there are limited data for this organism. Here we 13 showed that, when given a choice among two color combinations (R-Y, 14 R-G, Y-G, B-G, B-R, B-Y), shoals of zebrafish exhibited a complex 15 pattern of color preference and the order of RYGB preference was 16 R>Y>G, B>G. By contrast, the individual zebrafish showed marked 17 changes, completely losing their preference for all the tested color 18 combinations. To investigate the role of shoaling behavior in color 19preference, we selected a D1-receptor antagonist (SCH23390), which 20 could disrupt social preference and decrease social interaction in 21 zebrafish. Interestingly, the shoals that were treated by SCH23390 22 showed no color preference for all color combinations. Our findings 23 indicate that social interaction is involved in color-driven behavior in 24 zebrafish, and reveal the possible mechanisms that the dopaminergic 25 system may contribute to innate color preference in shoals of zebrafish. 26 27 28 Recently, Park et al. used zebrafish larvae (5 days post fertilization (dpf)) 60to test the innate color preference in shoals [19]. However, shoaling 61 behavior usually starts to develop after 7 dpf, becoming progressively 62 stronger for the mature [20][21][22]. As far as we know, no research has been 63 published that investigate the innate color preference of mature shoals, 64 although shoaling and social behavior in general has received 65 considerable critical attentions. 66The cohesion of shoals has been found to be associated with the 67 whole brain dopamine level [23]. Dopamine is one of the major 68 neurotransmitters in the central nervous system of the vertebrate brain 69 which plays important roles in a variety of cerebral functions, such as 70 mood, attention, reward and memory [24][25][26]. Abundant evidence shows 71 that dopamine is associated with the neurobehavioral functions in 72 zebrafish [27,28]. Saif et al. [27] found that strong social stimuli will 73 increase the dopamine and its metabolite 3,4-dihydroxyphenylacetic acid 74 (DOPAC) levels in the brain of the adult zebrafish. The short-term 75 isolated zebrafish could reduce the level of DOPAC [28]. The social 76 interaction of shoals in zebrafish can be affected by the dopaminergic 77 system through influence of the dopamine level [29]. D1 dopamine 78 receptor antagonist (SCH23390) is most abundantly expressed dopamine 79 receptor subtypes in the brain of zebrafish [30]. And SCH23390 disrupts 80 social preference of zebrafish by decreasing the level of dopamine in 81 dopaminergic system [31,32]. 82In the present study, we used two-color combinations (R-Y, R-G, 83 Y-G, B-G, B-R, B-Y) to test the innate color preference of shoal (10 adult 84 zebrafish) and individual fish, respectively. Moreover, we evaluated the 85 influence of social interac...

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Modulatory effects of dopamine receptors on associative learning performance in zebrafish (Danio rerio)

Cited by 40 publications

References 97 publications

Dopamine D1 receptor activation leads to object recognition memory in a coral reef fish

Dopamine D1 receptor activation leads to object recognition memory in a coral reef fish

Domperidone upregulates dopamine receptor expression and stimulates locomotor activity in larval zebrafish (Danio rerio)

Social interaction influences innate color preference of zebrafish shoals

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