Modulatory effects of the amygdala on oestrogen-induced LH secretion in ovariectomized rats

Abstract

An increase in LH secretion was induced in ovariectomized oestradiol benzoate-primed rats 5 h after a second injection of oestradiol benzoate. Lesions stereotaxically placed in the cortical and basomedial amygdala of steroid-primed rats abolished this rise. The results provide evidence for a facilitatory action of the amygdala upon LH release and an involvement of this region of the limbic system in oestrogen-feedback mechanisms.

Enhancement of the luteinising hormone surge by male olfactory signals is associated with anteroventral periventricular Kiss1 cell activation in female rats

“…20 The oestrogen-induced LH surge was abolished by lesion of the cortical and basomedial amygdala in female rats. 58 Interestingly, the present study demonstrates that femalesoiled bedding exposure tended to reduce the number of c-Fosimmunopositive kisspeptin neurones in the AVPV of OVX+E 2 rats ( Figure 1B) and exposure to female-soiled bedding tended to decrease the number of females that showed an apparent LH surge (see Supporting information, Figure S3). These results suggest that olfactory signals derived from females may have a role in suppressing AVPV kisspeptin neuronal excitability.…”

“…The MeA integrates neural signals from the vomeronasal and main olfactory systems and relays the signals to the AVPV . The oestrogen‐induced LH surge was abolished by lesion of the cortical and basomedial amygdala in female rats . These results suggest that the activation of AVPV kisspeptin neurones by olfactory signals may be mediated by amygdaloid neurones/glia.…”