Modulatory Mechanisms of the NLRP3 Inflammasomes in Diabetes

Ding, Sujuan; Xu, Sheng; Ma, Yong; Liu, Gang; Jang, Hongmei; Fang, Jun

doi:10.3390/biom9120850

Cited by 176 publications

(127 citation statements)

References 123 publications

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“…Active inflammasomes can lead to caspase 1-mediated activation of IL-1β [ 38 ]. This effect suggests a potential therapeutic impact of EEO on inflammatory diseases involving the inflammasome, such as type 2 diabetes [ 39 ], inflammatory bowel disease [ 40 ], and atherosclerosis [ 41 ].…”

Section: Eucalyptus Essential Oilmentioning

confidence: 99%

Immunomodulatory Activities of Selected Essential Oils

2020

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Recently, the application of herbal medicine for the prevention and treatment of diseases has gained increasing attention. Essential oils (EOs) are generally known to exert various pharmacological effects, such as antiallergic, anticancer, anti-inflammatory, and immunomodulatory effects. Current literature involving in vitro and in vivo studies indicates the potential of various herbal essential oils as suitable immunomodulators for the alternative treatment of infectious or immune diseases. This review highlights the cellular effects induced by EOs, as well as the molecular impacts of EOs on cytokines, immunoglobulins, or regulatory pathways. The results reviewed in this article revealed a significant reduction in relevant proinflammatory cytokines, as well as induction of anti-inflammatory markers. Remarkably, very little clinical study data involving the immunomodulatory effects of EOs are available. Furthermore, several studies led to contradictory results, emphasizing the need for a multiapproach system to better characterize EOs. While immunomodulatory effects were reported, the toxic potential of EOs must be clearly considered in order to secure future applications.

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Section: Eucalyptus Essential Oilmentioning

confidence: 99%

Immunomodulatory Activities of Selected Essential Oils

2020

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“…The overexpression of P2X7 receptor exhibits adverse effects on diabetic retinopathy, diabetic neuropathy, and diabetic nephropathy [67][68][69], and the impaired activation of the P2X7 receptor signaling pathway in T1DM may affect the function of osteoblasts and bone health [70,71]. When glucose metabolism is disordered, excessive extracellular ATP level stimulates macrophages in the pancreas and adipose tissues, thus prompting P2X7 receptors to activate NLRP3 inflammasomes [72]. The increased level of NLRP3-dependent IL-1β induces and aggravates T2DM through β cell death and insulin resistance.…”

Section: Role Of P2x7 Receptor In Dmmentioning

confidence: 99%

P2X7 receptor mediates NLRP3 inflammasome activation in depression and diabetes

Wang

Gao

et al. 2020

Cell Biosci

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The increasing prevalence of depression and diabetes mellitus has become a major public health problem worldwide. Studies have shown that people with diabetes are at a high risk of being diagnosed with depression, and diabetes complicates depression treatment by promoting the deterioration of glycemic control, reducing self-care ability and quality of life, and causing severe functional disability and early mortality. Moreover, health deterioration dramatically increases the financial cost of social and health care system. Thus, how to treat depression, diabetes, and diabetes complicated by depression has become one of the world's urgent concerns. The activation of nod-like receptor family pyrin domain containing 3 (NLRP3) is closely related to mental illness. This finding provides a new perspective for studying depression. NLRP3 plays an important role in the development of diabetes. In this review, we elaborate the definition and epidemiology of depression, diabetes, and diabetic depression and introduce the functional characteristics of an NLRP3 inflammasome and upstream P2X7 receptor. Moreover, related research on NLRP3 inflammasomes and P2X7 receptors is summarized and used as a reference for confirming that the excessive activation of P2X7-NLRP3 leads to the increased release of inflammatory cytokines, such as IL-1β, in depression and diabetes. We provide insights into the P2X7-NLRP3-IL-1β pathway as an important pathological mechanism and novel therapeutic target in diabetes and depression. Given that the P2X7-NLRP3-IL-1β pathway may play an important role in diabetes confounded by comorbid depression, the possibility of intervention with baicalin is proposed.

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“…Another way to modulate the innate immune response is to regulate the activation of particular inflammasomes ( Broz and Dixit, 2016 ; Ding et al, 2019 ; Spel and Martinon, 2020 ). Among various types of inflammasomes, nucleotide-binding domain and leucine-rich-repeat-containing family and pyrin domain-containing 3 (NLRP3) is implicated in Alzheimer’s disease and type 2 diabetes upon aberrant activation.…”

Section: Application In Inflammation Regulationmentioning

confidence: 99%

Plant-Derived Nanovesicles: A Novel Form of Nanomedicine

Deng

Liu

et al. 2020

Front. Bioeng. Biotechnol.

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The nanovesicles extracted from the plant and herbal decoctions are identified as a new class of nanomedicine. They are involved in interspecies chemical communication across the plant and animal kingdoms and display a therapeutic potential against a variety of diseases. Herein, we review the recent progress made in the medical applications of plant-derived nanovesicles in the aspects of anti-inflammation, anti-cancer, tissue regeneration, and modulating commensal microbiota. We further summarize the cellular and molecular mechanisms underlying the physiological functions of plant-derived nanovesicles. Overall, plant-derived nanovesicles provide an alternative to conventional synthetic drugs and present exciting opportunities for future research on disease therapy.

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Modulatory Mechanisms of the NLRP3 Inflammasomes in Diabetes

Cited by 176 publications

References 123 publications

Immunomodulatory Activities of Selected Essential Oils

Immunomodulatory Activities of Selected Essential Oils

P2X7 receptor mediates NLRP3 inflammasome activation in depression and diabetes

Plant-Derived Nanovesicles: A Novel Form of Nanomedicine

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