Modulatory role of grape seed extract on age-related oxidative DNA damage in central nervous system of rats

Balu, Muthaiya; Sangeetha, P.; Ganesan, Murali; Panneerselvam, C.

doi:10.1016/j.brainresbull.2005.10.007

Cited by 87 publications

(66 citation statements)

References 34 publications

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“…Therefore, it must be assumed that GSW is palatable to the horse. Other researchers have found similarly unchanged feed intakes in other species fed comparable amounts of GSE (Gontheir et al, 2003;Balu et al, 2005). However, Wren et al (2002) fed much higher doses (102 to 1586 mg/kg BW) to rats and noted an increase in feed intake.…”

Section: Resultsmentioning

confidence: 75%

Feeding grape seed extract to horses: effects on health, intake and digestion

Davies

Krebs

Barnes

et al. 2009

Animal

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A feeding trial involving four Thoroughbred race horses was undertaken to establish whether inclusion of grape seed extract (GSE) in the diet of horses undergoing mild exercise had any effects on their general health, intake and digestion. Supplementation with GSE had no effect on either feed or water intake of the horses and the supplement was readily palatable to the horses at all levels of inclusion. Feeding GSE caused no adverse effects in terms of animal health (temperature, pulse and respirations rates), and there were some positive effects related to a presumed alteration in fermentation in the hindgut. Feeding GSE increased faecal pH, changing from acid faeces (pH 6.6) when no GSE was fed to neutral faeces (pH 7.0) when 150 mg GSE/kg body weight (BW) was fed. In addition, blood glucose concentrations were significantly ( P , 0.05) decreased when GSE was fed at 100 and 150 mg/kg BW (5.50 6 0.26 and 5.32 6 0.72 mmol/l, respectively) compared with the control diet (5.77 6 0.31 mmol/l). The actual mechanisms causing these alterations are yet to be elucidated, but could have important implications for the prevention of acidosis.

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Section: Resultsmentioning

confidence: 75%

Feeding grape seed extract to horses: effects on health, intake and digestion

Davies

Krebs

Barnes

et al. 2009

Animal

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“…Garlic has shown to possess important antioxidant properties through its ability to scavenge free radicals (Carmia, 2001), inhibit lipid peroxidation and reduce oxidative stress and mutations (Shaarawy et al, 2009). Moreover, curcumin plays a vital role in protecting cells from oxidative stress and the resulting damage to DNA (Balu, Sangeetha, Murali, & Panneerselvam, 2006) and, it also inhibits the production of AFB1-epoxide (Firozi, Aboobaker, & Bhattacharya,.1996) by significantly reducing CYP1A1 activity and enhancing glutathione activity to ameliorate the effects of AFB1 (Sujatha & Sashidhar, 2010).…”

Section: Introductionmentioning

confidence: 99%

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El‐Barbary¹

2018

Turk. J. Fish. Aquat. Sci.

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Aflatoxin B1 is one of the most important mycotoxins due to its hepatotoxic and carcinogenic effects on some fishes. This study was conducted to investigate the defensive role of curcumin and garlic on phase I of the biotransformation system in the liver of aflatoxicosis in Oreochromis niloticus in relation to the therapeutic properties by studying hepatic histopathology and cytochrome P450-CYP1A gene expression using real-time polymerase chain reaction (RT-PCR). Although varieties of methods have been used for gene expression quantification and are still used today, real-time RT-PCR method has achieved prominence in recent years. One hundred and eighty (180) fish were equally divided into 10 groups. T1 was the negative control; fish in T2 were injected intraperitonealy (IP) with AFB1 at a rate of 6 mg kg -1 B.W. and fed on a basal diet. Groups T3-T6 were fed with garlic (T3 & T4) and curcumin (T5 & T6) at 10 & 20 g kg -1 diet, respectively. Groups T7-T10 injected IP with AFB1 and fed on both garlic and curcumin at the different concentrations (10 & 20 g kg -1 diet). AFB1 reduced the HSI values in aflatoxicosis fish. Feeding a low dose of garlic led to significant improvement in the HSI values. Histologically, hepatic lesions were observed in the AFB1 injected groups; damage was reduced when fish were fed on garlic and curcumin diets at a concentration 10 g kg -1. The highest induction of CYP1A expression was observed in the curcumin groups followed by AFB1. The over expression of CYP1A in T2 was alleviated by the garlic. Therefore, it was found that garlic enhances the detoxification of AFB1 through the suppression of CYP1A in the liver.

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“…Furthermore, at the testis level, OS is involved in steroidogenesis impairment and germinal epithelium differentiation disruption (9,10). Growing evidence demonstrates that the black grape (Vitis vinifera) and its seed possess a broad spectrum of pharmacological properties, including free-radical scavenging (11), antitumor (12), antifibrotic (13), anti-apoptotic (14), and anti-inflammatory activities (15). Moreover, recent studies have revealed that grape seed extract (GSE) has a potential reproprotective effect in male reproductive disorders (16,17).…”

Section: Introductionmentioning

confidence: 99%

Black Grape Seed Extract Modulates Fluoxetine-Induced Oxidative Stress and Cytotoxicity in the Mouse Testis

Hajizadeh

Mehranjani

Najafi

et al. 2016

Jundishapur J Nat Pharm Prod

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Background: Fluoxetine (FLX), a selective serotonin reuptake inhibitor, is widely used in the treatment of neurological disorders. However, its application carries the risk of adverse reactions, including reproductive toxicities. Grape seed is highly regarded for its pharmacological activities, specifically its antioxidant properties. Objectives: This study was designed to evaluate whether hydroalcoholic grape seed extract (GSE) could ameliorate FLX-evoked oxidative injuries in the mouse testis. Materials and Methods: Thirty-two male mice were categorized into four groups of eight mice each. Two groups received FLX at a dose of 20 mg/kg per day over a period of six weeks by oral gavage. One of these groups received GSE at a dose of 100 mg/kg per day orally along with the FLX. An untreated control group and a GSE-only treated group were also included. Serum and testicular samples were collected 24 hours after the last treatment. Results: Biochemical analyses demonstrated that FLX caused significant decreases in testicular antioxidant capacity and serum testosterone concentrations, as well as lipid peroxidation elevations in testicular tissue. Morphometric and histopathological studies supported the biochemical findings. Concomitant administration of GSE with FLX markedly reduced testicular damage and significantly restored all of the mentioned markers to normal values. Conclusions:The findings suggested that oxidative stress-mediated testicular damage, arising as a result of FLX administration in mice, could be reversed by GSE.

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Modulatory role of grape seed extract on age-related oxidative DNA damage in central nervous system of rats

Cited by 87 publications

References 34 publications

Feeding grape seed extract to horses: effects on health, intake and digestion

Feeding grape seed extract to horses: effects on health, intake and digestion

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Black Grape Seed Extract Modulates Fluoxetine-Induced Oxidative Stress and Cytotoxicity in the Mouse Testis

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