Module-assisted synthesis of the bifunctional labelling agent N-succinimidyl 4-[18F]fluorobenzoate ([18F]SFB)

Synthesis and Biologic Evaluation of Novel 18F-Labeled Probes Targeting Prostate-Specific Membrane Antigen for PET of Prostate Cancer

“…However, the radiochemical yield of 18 F-DCFPyL is low (2.8% 6 1.2%) (18). To overcome this disadvantage, we designed novel PSMA-targeting probes using 18 F-SFB, which has been obtained with a high radiochemical yield using the automated facile synthesis (20)(21)(22)(23)(24)(25). The design of these novel PSMA imaging probes was based on the results of our previous study.…”

“…This compound, however, has a low radiochemical yield (2.8% 6 1.2%) (18). Recently, an 18 F-labeling reagent, 18 F-SFB, with high radiochemical yield, obtained using automated facile synthesis has become available (20)(21)(22)(23)(24)(25). Thus, we decided to design novel PSMA-targeted probes labeled with 18 F-SFB.…”

A Molecular Imaging Primer: Modalities, Imaging Agents, and Applications

“…In addition, peptides used for PET and SPECT imaging mostly require prosthetic groups (265,273) to label them with radioisotopes. Prosthetic groups add to the complexity and time of synthesis, and also alter the structure and can therefore change the binding of the peptide.…”

Microwave-assisted One-pot Synthesis of <em>N</em>-succinimidyl-4-[¹⁸F]fluorobenzoate ([¹⁸F]SFB)

“…As indicated in Figure 1, each transformation was complete within 1-2 min under microwave heating; in comparison, it generally requires 5 -10 minutes when using conventional conduction heating (e.g., oil bath or heater block). [29][30][31][32][41][42] With a significant reduction in its overall complexity, we believe that this improved and concise synthesis will make the routine production of [ 18 F]SFB more practical and attractive for adoption in automated modules, enabling the use of 18 F-labeled biomolecules 43 as research tools to accelerate biomedical discovery and enhance clinical studies.…”