MODY 3 and acromegaly: An improbable association treated with bromocriptine

Puga, F; Amaral, Claudia; Cláudia, Freitas; Cardoso, Maria Helena

doi:10.1530/endoabs.73.aep551

Cited by 1 publication

(2 citation statements)

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“…In terms of ease, bromocriptine as well as other effective dopamine agonists are most likely well accepted among patients because of its availability in oral dosage form 231 . Moreover, bromocriptine has also been seen to have beneficial effects in acromegaly accompanying glucose abnormalities 245,246 . Vandeva et al 247 analysed the efficacy of bromocriptine and cabergoline in 133 and 70 patients and achieved 18.8% and 31.4% disease control rate, respectively.…”

Section: Pharmacological Significance Of Bromocriptinementioning

confidence: 99%

“…231 Moreover, bromocriptine has also been seen to have beneficial effects in acromegaly accompanying glucose abnormalities. 245,246 Vandeva et al 247 analysed the efficacy of bromocriptine and cabergoline in 133 and 70 patients and achieved 18.8% and 31.4% disease control rate, respectively. Similarly, 16.3% and 18.2% control rates for bromocriptine and cabergoline, respectively, in patients without prior radiotherapy.…”

Section: Bromocriptine In Acromegalymentioning

confidence: 99%

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Bromocriptine therapy: Review of mechanism of action, safety and tolerability

Naz

Malik

Riaz

et al. 2022

Clin Exp Pharma Physio

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Bromocriptine is a sympatholytic dopamine D2 receptor agonist with remarkable bioactivities. It has been used clinically as a prescription drug for more than 30 years to treat hyperprolactinemia associated conditions, Parkinson's disease, acromegaly, prolactinomas and other pituitary hormone dependent adenomas and recently, diabetes mellitus as well as various other disorders. Long‐term treatment with bromocriptine has minimal or no harmful effects on renal, hepatic, cardiac or hematologic functions. This review article was planned to study the hypothetical and proposed mechanism of action as well as provide a brief discussion about its safety issues and tolerability. Bromocriptine represents an attractive option with high efficacy and safety profile for hyperprolactinemia‐associated conditions, acromegaly, parkinsonism, type 2 diabetes mellitus and various other diseases in a variety of dosage forms for best possible beneficial effects. It appeared to be an effective and safe addition to the pharmacopoeia of drugs for the treatment of a vast variety of diseases as monotherapy or in combination with other drugs.

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Section: Pharmacological Significance Of Bromocriptinementioning

confidence: 99%