MOF-derived bimetallic nanozyme to catalyze ROS scavenging for protection of myocardial injury

Xiang, Kaiyan; Wu, Haoguang; Yu, Li; Sheng, Wang; Li, Xueling; Yang, Bowei; Zhang, Yunming; Ma, Lina; He, Liangcan; Ni, Qianqian; Zhang, Long Jiang

doi:10.7150/thno.83543

Cited by 38 publications

(10 citation statements)

References 73 publications

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“…ROS, whether exogenously or endogenously overproduced, can lead to an imbalance in redox homeostasis [ 42 ]. Although elevated levels of virus-induced ROS trigger innate antiviral immunity, a recent study reported that ROS production is beneficial for viral replication [ 43 ].…”

Section: Discussionmentioning

confidence: 99%

Metabolomics combined with network pharmacology reveals a role for astragaloside IV in inhibiting enterovirus 71 replication via PI3K-AKT signaling

Hao,

Zhang,

et al. 2024

J Transl Med

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Background Astragaloside IV (AST-IV), as an effective active ingredient of Astragalus membranaceus (Fisch.) Bunge. It has been found that AST-IV inhibits the replication of dengue virus, hepatitis B virus, adenovirus, and coxsackievirus B3. Enterovirus 71 (EV71) serves as the main pathogen in severe hand-foot-mouth disease (HFMD), but there are no specific drugs available. In this study, we focus on investigating whether AST-IV can inhibit EV71 replication and explore the potential underlying mechanisms. Methods The GES-1 or RD cells were infected with EV71, treated with AST-IV, or co-treated with both EV71 and AST-IV. The EV71 structural protein VP1 levels, the viral titers in the supernatant were measured using western blot and 50% tissue culture infective dose (TCID50), respectively. Network pharmacology was used to predict possible pathways and targets for AST-IV to inhibit EV71 replication. Additionally, ultra-high performance liquid chromatography-high resolution mass spectrometry (UHPLC-HRMS) was used to investigate the potential targeted metabolites of AST-IV. Associations between metabolites and apparent indicators were performed via Spearman’s algorithm. Results This study illustrated that AST-IV effectively inhibited EV71 replication. Network pharmacology suggested that AST-IV inhibits EV71 replication by targeting PI3K-AKT. Metabolomics results showed that AST-IV achieved these effects by elevating the levels of hypoxanthine, 2-ketobutyric acid, adenine, nicotinic acid mononucleotide, prostaglandin H2, 6-hydroxy-1 H-indole-3- acetamide, oxypurinol, while reducing the levels of PC (14:0/15:0). Furthermore, AST-IV also mitigated EV71-induced oxidative stress by reducing the levels of MDA, ROS, while increasing the activity of T-AOC, CAT, GSH-Px. The inhibition of EV71 replication was also observed when using the ROS inhibitor N-Acetylcysteine (NAC). Additionally, AST-IV exhibited the ability to activate the PI3K-AKT signaling pathway and suppress EV71-induced apoptosis. Conclusion This study suggests that AST-IV may activate the cAMP and the antioxidant stress response by targeting eight key metabolites, including hypoxanthine, 2-ketobutyric acid, adenine, nicotinic acid mononucleotide, prostaglandin H2, 6-Hydroxy-1 H-indole-3-acetamide, oxypurinol and PC (14:0/15:0). This activation can further stimulate the PI3K-AKT signaling to inhibit EV71-induced apoptosis and EV71 replication. Graphical Abstract

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Section: Discussionmentioning

confidence: 99%

Metabolomics combined with network pharmacology reveals a role for astragaloside IV in inhibiting enterovirus 71 replication via PI3K-AKT signaling

Hao,

Zhang,

et al. 2024

J Transl Med

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“…Therefore, timely relief of inflammation is essential for the regeneration of injured tissues. Many studies have shown that MOFs are promising anti-inflammatory materials [ 145–147 ]. For instance, Kang et al .…”

Section: Function Of Mofs In Mofs-based Biomaterials For Tissue Engin...mentioning

confidence: 99%

Application of metal-organic frameworks-based functional composite scaffolds in tissue engineering

Yao,

Chen,

Sun

et al. 2024

Regenerative Biomaterials

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With the rapid development of materials science and tissue engineering, a variety of biomaterials have been used to construct tissue engineering scaffolds. Due to the performance limitations of single materials, functional composite biomaterials have attracted great attention as tools to improve the effectiveness of biological scaffolds for tissue repair. In recent years, metal organic frameworks (MOFs) have shown great promise for application in tissue engineering because of their high specific surface area, high porosity, high biocompatibility, appropriate environmental sensitivities and other advantages. This review introduces methods for the construction of MOFs-based functional composite scaffolds and describes the specific functions and mechanisms of MOFs in repairing damaged tissue. The latest MOFs-based functional composites and their applications in different tissues are discussed. Finally, the challenges and future prospects of using MOFs-based composites in tissue engineering are summarized. The aim of this review is to show the great potential of MOFs-based functional composite materials in the field of tissue engineering and to stimulate further innovation in this promising area.

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“…2 Optimization strategies for single-atom nanozymes at both framework structure and active center levels from MOFs have combined high catalytic properties for SOD and CAT, and can synergistically scavenge ROS (Fig. 3C) [22]. Another crystalline porous materials, COF, constructed through covalently linked organic units, show excellent properties for synthesizing SAzymes [23][24][25].…”

Section: Optimization Of Framework Structurementioning

confidence: 99%

Single-atom nanozymes shines diagnostics of gastrointestinal diseases

Hua,

Dong,

Peng

et al. 2024

J Nanobiotechnol

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Various clinical symptoms of digestive system, such as infectious, inflammatory, and malignant disorders, have a profound impact on the quality of life and overall health of patients. Therefore, the chase for more potent medicines is both highly significant and urgent. Nanozymes, a novel class of nanomaterials, amalgamate the biological properties of nanomaterials with the catalytic activity of enzymes, and have been engineered for various biomedical applications, including complex gastrointestinal diseases (GI). Particularly, because of their distinctive metal coordination structure and ability to maximize atom use efficiency, single-atom nanozymes (SAzymes) with atomically scattered metal centers are becoming a more viable substitute for natural enzymes. Traditional nanozyme design strategies are no longer able to meet the current requirements for efficient and diverse SAzymes design due to the diversification and complexity of preparation processes. As a result, this review emphasizes the design concept and the synthesis strategy of SAzymes, and corresponding bioenzyme-like activities, such as superoxide dismutase (SOD), peroxidase (POD), oxidase (OXD), catalase (CAT), and glutathione peroxidase (GPx). Then the various application of SAzymes in GI illnesses are summarized, which should encourage further research into nanozymes to achieve better application characteristics. Graphical abstract

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MOF-derived bimetallic nanozyme to catalyze ROS scavenging for protection of myocardial injury

Cited by 38 publications

References 73 publications

Metabolomics combined with network pharmacology reveals a role for astragaloside IV in inhibiting enterovirus 71 replication via PI3K-AKT signaling

Metabolomics combined with network pharmacology reveals a role for astragaloside IV in inhibiting enterovirus 71 replication via PI3K-AKT signaling

Application of metal-organic frameworks-based functional composite scaffolds in tissue engineering

Single-atom nanozymes shines diagnostics of gastrointestinal diseases

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