MOF derived core-shell CuO/C with temperature-controlled oxygen-vacancy for real time analysis of glucose

Abstract

Introducing oxygen-vacancy into the surface of the non-enzymatic sensor is supposed to be an effective way to improve inherently low catalytic activity and specificity of non-enzymatic sensors. In this work, CuO/C was synthesized at different temperatures using metal-organic frameworks as sacrificial templates to receive additional content of oxygen-vacancy. The product with the highest oxygen vacancy was found at 400 °C (named CuO/C-400 °C), which increased catalytically active sites and enhanced the charge-transfer efficiency. The sensing performance was afterward explored by amperometry under an optimal applied potential at 0.5 V (vs. SCE), presenting a broad detection range from 5.0 µM to 25.325 mM (R2 = 0.9998) with a sensitivity of 244.71 µA mM− 1 cm− 2, and a detection limit of 1 µM. Furthermore, the reliability and selectivity of CuO/C-400 °C sensors were extensively explored in the presence of artificial serum/saliva samples with gradient glucose concentrations. The human blood samples were also detected with high recoveries compared with the clinical Hexokinase method. Hence, the prepared CuO/C-400 °C sensor with a broad detection range and high selectivity can be applied for the diabetes diagnosis ex vivo without further dilution for real-time analysis in practical applications.

MOF-Based Materials for Glucose Detection

“…In order to obtain the desired MOF-derived materials, the unde element components should be removed by post-processing. One of the most comm used methods is thermal treatment at a specific temperature and atmosphere [97 shown in Figure 5A, Qin et al synthesized CuO/C core-shell nanoparticles by calcin Cu-MOF as sacrificial templates at 400 °C in air [98]. The interaction between the ca shell and CuO core increased the charge transfer efficiency and the oxygen vacancy tent, which endowed the catalytic oxidation capacity of CuO/C for glucose.…”

“…Furthermore, MOF-derived rials synthesized by pyrolysis also include CuO/NiO-C (Cu/Ni-MOF) [100], CuO (Cu [101], and NiFe2O4 (NiFe-MOF) [102], etc. [98], copyr 2022, Springer Nature). (B) The synthesis strategy of YASNiCo@C (reproduced with perm from [99], copyright © 2020, Royal Society of Chemistry).…”

“…Figure 5. (A)The synthesis strategy of CuO/C (reproduced with permission from[98], copyr 2022, Springer Nature). (B) The synthesis strategy of YASNiCo@C (reproduced with perm from[99], copyright © 2020, Royal Society of Chemistry).…”

Multifaceted Carbonized Metal–Organic Frameworks Synergize with Immune Checkpoint Inhibitors for Precision and Augmented Cuproptosis Cancer Therapy

“…Metal–organic frameworks (MOFs) have garnered significant attention in recent years owing to their structural versatility, tunable properties, and diverse range of applications. − In particular, MOF derivatives (modified versions of MOFs) have shown potential in drug delivery, diagnostic imaging, and photodynamic therapy for cancer, among other modalities. − These derivatives can be customized via surface modification, functionalization with different ligands, or the encapsulation of guest molecules. , Interestingly, carbonized MOFs (cMOFs) usually exhibit higher stability than their parent MOFs and can also maintain structural integrity within the tumor microenvironment, thus showing potential for cancer therapy. Furthermore, these MOFs also exhibit superior biocompatibility, which makes them more suitable for biomedical applications such as drug delivery and imaging. , The multifunctionality and customizability of localized carbonized MOFs make them ideal candidate platforms for targeted cancer therapy, potentially leading to advanced treatment modalities. − …”

Controlled synthesized of ternary Cu-Co-Ni-S sulfides nanoporous network structure on carbon fiber paper: a superior catalytic electrode for highly-sensitive glucose sensing

“…The International Diabetes Federation (IDF) estimates that the number of deaths due to diabetes is projected to rise steadily to approximately 700 million by the 2040s [ 2 ]. For quick patient screening and medical monitoring, it is of great importance to develop highly responsive and specific rapid diagnostic glucose sensors in clinics [ 3 , 4 ]. To this day, glucose sensors used in commercial applications primarily rely on electrooxidation facilitated by glucose oxidase [ 5 ].…”