MOF@SiO 2 core-shell composites as stationary phase in high performance liquid chromatography

Ehrling, Sebastian; Kutzscher, Christel; Freund, Pascal; Müller, Philipp; Senkovska, Irena; Kaskel, Stefan

doi:10.1016/j.micromeso.2018.01.003

Cited by 68 publications

(23 citation statements)

References 28 publications

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“…In any case, the incorporation of MOFs as stationary phases in GC and LC, or as pseudo-stationary phases in capillary electro-chromatography (CEC), benefits from the low numbers of MOFs required in such phases, together with the clear reutilization of such phases. Table 3 includes a summary of representative analytical applications of MOFs when included as stationary of pseudo-stationary phases in different chromatographic techniques in the last three years [101][102][103][104][105][106][107][108][109][110][111][112][113][114][115]. Mostly, MOFs form part of composites with silica or polymers in such phases [101,102], hardly being utilized in its neat appearance.…”

Section: Mofs In Chromatographymentioning

confidence: 99%

Metal-Organic Frameworks in Green Analytical Chemistry

et al. 2019

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Metal-organic frameworks (MOFs) are porous hybrid materials composed of metal ions and organic linkers, characterized by their crystallinity and by the highest known surface areas. MOFs structures present accessible cages, tunnels and modifiable pores, together with adequate mechanical and thermal stability. Their outstanding properties have led to their recognition as revolutionary materials in recent years. Analytical chemistry has also benefited from the potential of MOF applications. MOFs succeed as sorbent materials in extraction and microextraction procedures, as sensors, and as stationary or pseudo-stationary phases in chromatographic systems. To date, around 100 different MOFs form part of those analytical applications. This review intends to give an overview on the use of MOFs in analytical chemistry in recent years (2017–2019) within the framework of green analytical chemistry requirements, with a particular emphasis on possible toxicity issues of neat MOFs and trends to ensure green approaches in their preparation.

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Section: Mofs In Chromatographymentioning

confidence: 99%

Metal-Organic Frameworks in Green Analytical Chemistry

et al. 2019

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“…SiO 2 material with a porous structure, known as a stably, nontoxically, harmlessly and low-costly photonic crystalline material, has been widely applied to various areas, such as catalyst supports [ 6 – 8 ], adsorbents [ 9 – 11 ], chromatographic materials [ 12 , 13 ], and biosensors [ 14 , 15 ]. In particular, the SiO 2 inverse opal photonic crystal (IOPC) biosensors have been fabricated based on changes in their photoluminescence properties or reflective spectra.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of SiO2/PEGDA Inverse Opal Photonic Crystal with Fluorescence Enhancement Effects

Dinh

Nguyen

et al. 2021

Journal of Analytical Methods in Chemistry

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The present paper reports the fabrication of inverse opal photonic crystals (IOPCs) by using SiO2 spherical particles with a diameter of 300 nm as an opal photonic crystal template and poly(ethylene glycol) diacrylate (PEGDA) as an inverse opal material. Characteristics and fluorescence properties of the fabricated IOPCs were investigated by using the Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), X-ray diffraction (XRD), reflection spectroscopy, and fluorescence microscopy. The results clearly showed that the IOPCs were formed comprising of air spheres with a diameter of ∼270 nm. The decrease in size led to a decrease in the average refractive indexes from 1.40 to 1.12, and a remarkable stopband blue shift for the IOPCs was thus achieved. In addition, the obtained results also showed a fluorescence enhancement over 7.7-fold for the Fluor® 488 dye infiltrated onto the IOPCs sample in comparison with onto the control sample.

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“…In pharmaceutical applications, enhancing the water stability, mechanical strength, and biocompatibility of MOFs while maintaining their other advantages remains a big challenge [23][24][25]. To solve this problem, researchers have attempted to fabricate MOF nanocomposites with other materials, such as polymers, silica, graphene, or carbon nanotubes, which have different properties, as the reinforcement phase [26][27][28][29][30][31][32][33][34][35][36][37][38]. Silica is suitable for preparation of composite materials to improve the performance of MOFs due to its high stability and structural adjustability [39][40][41][42].…”

Section: Introductionmentioning

confidence: 99%

Metal Organic Framework@Polysilsesequioxane Core/Shell-Structured Nanoplatform for Drug Delivery

Gao

et al. 2020

Pharmaceutics

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Modern pharmaceutics requires novel drug loading platforms with high drug loading capacity, controlled release, high stability, and good biocompacity. Metal–organic frameworks (MOFs) show promising applications in biomedicine owing to their extraordinarily high surface area, tunable pore size, and adjustable internal surface properties. However, MOFs have low stability due to weak coordinate bonding and limited biocompatibility, limiting their bioapplication. In this study, we fabricated MOFs/polysilsesquioxane (PSQ) nanocomposites and utilized them as drug carriers. Amine-functionalized MOF (UiO-66-NH2) nanoparticles were synthesized and encapsulated with epoxy-functionalized polysilsesquioxane layer on the surface via a facile process. MOFs possessed high surface area and regular micropores, and PSQs offered stability, inertness, and functionality. The obtained UiO-66-NH2@EPSQ nanocomposites were utilized as carriers for ibuprofen, a drug with carboxylic groups on the surface, and demonstrated high drug loading capacity and well-controlled release property. The UiO-66-NH2@EPSQ nanocomposite exhibited low cytotoxicity to HeLa cells within a wide concentration range of 10–100 µg/mL, as estimated by the MTT method. The UiO-66-NH2@EPSQ drug release system could be a potential platform in the field of controlled drug delivery.

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MOF@SiO 2 core-shell composites as stationary phase in high performance liquid chromatography

Cited by 68 publications

References 28 publications

Metal-Organic Frameworks in Green Analytical Chemistry

Metal-Organic Frameworks in Green Analytical Chemistry

Fabrication of SiO2/PEGDA Inverse Opal Photonic Crystal with Fluorescence Enhancement Effects

Metal Organic Framework@Polysilsesequioxane Core/Shell-Structured Nanoplatform for Drug Delivery

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