MOG-IgG Among Participants in the Pediatric Optic Neuritis Prospective Outcomes Study

Abstract

Myelin oligodendrocyte glycoprotein (MOG) immunoglobulin G (IgG)-associated disorder (MOGAD) is a recently described entity that is distinct from multiple sclerosis (MS) and aquaporin-4 (AQP4)-IgG-positive neuromyelitis optica spectrum disorder. 1-3 A small cohort from the Pediatric Optic Neuritis Prospective Outcomes Study 4 underwent MOG-IgG testing and we compared those whose results were MOG-IgG positive with those whose results were negative.Methods | The study, protocol, and Health Insurance Portability and Accountability Act-compliant informed consent forms were approved by each site's institutional review board. Each patient's parent or guardian provided written informed consent. Children also provided written consent when applicable as determined by the local institutional review board. Parents of 13 of 44 study participants who underwent MOG-IgG testing also provided written consent to provide their child's serum to the

Attack phenotypes and disease course in pediatric MOGAD

“… 31 Two studies reported median visual acuity of 1.0, one with an IQR of 1.0, 1.0 70 and one with a range of 0.8–1.0. 62 The logMAR was reported by three studies: one with median 0.0 (IQR 0.0, 1.0), 72 one with median 0.1, 71 and one with logMAR 0.0 in 73% of patients. 73 …”

“…Conversely, one study of 10 patients reported a median visual acuity of 1.0 (interquartile range (IQR) 0.2, 1.0) using the decimal scale 70 . Two studies reported the median logarithm of the minimal angle of resolution (logMAR) to be 1.7 71,72 …”

“… 70 Two studies reported the median logarithm of the minimal angle of resolution (logMAR) to be 1.7. 71 , 72 …”

“…70 Two studies reported the median logarithm of the minimal angle of resolution (logMAR) to be 1.7. 71,72 Studies reporting visual acuity consistently showed overall good to excellent visual outcomes following initial presentation in the majority of patients. Using the decimal scale, visual acuity of ≤0.2 was reported by three studies in 0% 6,14 to 20% of patients, 16 and <0.5 by two studies in 2% 69 and 6% 68 of patients.…”

The Consortium of Pediatric Neuro-Ophthalmologists (CPNO) and Fundamentals of Pediatric Neuro-Ophthalmology

“…1 This longitudinal data collection study was the first large multicenter one on this topic and has produced valuable information regarding visual outcomes and distribution of pediatric optic neuritis subtypes. [2][3][4] Claire Sheldon coordinated a multicenter study of anthropometrics in children with pediatric idiopathic intracranial hypertension (IIH). Her group found that there are 3 subgroups of pediatric IIH, compared with age and gender norms: 1) a population (younger than 8 years) with normal body mass index, 2) an early adolescent group that is either overweight or obese and tall, and 3) a late adolescent group that is mostly obese.…”