Mogamulizumab‐induced photosensitivity in patients with mycosis fungoides and other T‐cell neoplasms

Masuda, Yurika; Tatsuno, Kazuki; Kitano, Seiya; Miyazawa, Hidehiko; Ishibe, Junichi; Aoshima, Masahiro; Shimauchi, Takatoshi; Fujiyama, Toshiharu; Ito, Taisuke; Tokura, Y.

doi:10.1111/jdv.14797

Cited by 23 publications

(31 citation statements)

References 26 publications

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“…Attention should be paid to new types of photosensitivity, which are represented by the immune‐related adverse effect of mogamulizumab . Our recent observation on voriconazole photocarcinogenesis further suggests that a prodrug and its metabolite play different roles in conjunction with UV and construct a photodisordered condition .…”

Section: Discussionmentioning

confidence: 99%

“…The photosensitive lesions were characterized by a lichenoid tissue reaction with a CD8 + T‐cell–dominant infiltrate, sharing the feature with chronic actinic dermatitis (CAD), an autoreactive photodermatosis with a cytotoxic T‐cell response. Foxp3 + regulatory T cells (Tregs) were decreased in the photosensitivity lesions compared with the lymphoma lesions …”

Section: New Type Of Drug Photoallergymentioning

confidence: 99%

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Drug photoallergy

Tokura

2018

J Cutaneous Imm & Allergy

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Drugs are one of the representative exogenous agents that cause photosensitive dermatitis. Both phototoxic and photoallergic mechanisms exist in photosensitivity to exogenous agents. While the phototoxic reaction is mediated mainly by reactive oxygen species, the photoallergic reaction is induced and elicited by immunological consequences. Two hypotheses have been put forward to explain the formation of photoallergen: prohapten and photohapten. The vast majority of clinically photoallergic drugs are photohapten rather than prohapten. Clinically, photocontact dermatitis and drug photosensitivity are the two major disorders caused by topical and systemic exogenous photosensitizers, respectively. The main cause of photocontact dermatitis is nonsteroidal anti‐inflammatory drugs. In drug photosensitivity, various causative agents have been reported and are recently represented by hydrochlorothiazide, quinolones, piroxicam, and flutamide. Orally administered drugs diffuse from the blood to the epidermis, and keratinocytes are photoderivatized with a given drug upon ultraviolet (UV) A irradiation, leading to photoantigen formation and cytokine production. In parallel, dendritic cells become photohapten‐bearing, T‐cell–sensitizing cells. Considering the mechanisms of photoallergy to chemicals, several in vitro assessments have been proposed to detect the photoallergenicity. Finally, a recent observation with newly marketed drugs has demonstrated that drugs may function as immunomodulators and induce photosensitivity as typically seen in anti‐CCR4 antibody.

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Section: Discussionmentioning

confidence: 99%

Section: New Type Of Drug Photoallergymentioning

confidence: 99%

Drug photoallergy

Tokura

2018

J Cutaneous Imm & Allergy

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“…These eruptions are characterized by lichenoid tissue reactions with a CD 8+ T‐cell dominant infiltrate resembling chronic actinic dermatitis. Regulatory T cells (Foxp3+) were decreased …”

Section: Allergy and Eczemamentioning

confidence: 99%

Progress in Dermatology and Venereology – Editor's pick of the year 2018

Ring

2019

Acad Dermatol Venereol

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“…In the September issue of the Journal, an interesting paper of Masuda et al 4. reports on mogamulizumab‐induced photosensitivity.…”

mentioning

confidence: 99%

“…Thus, there is no convincing explanation for a true drug‐induced photosensitivity. Whether a decrease in Foxp3+ regulatory T cells (Tregs) in the suspected photosensitivity lesions compared with the lymphoma lesions may be responsible, could perhaps be one of several hypotheses but this awaits objective evidence.…”

mentioning

confidence: 99%