Mogroside-rich extract from <i>Siraitia grosvenorii</i> fruits protects against heat stress-induced intestinal damage by ameliorating oxidative stress and inflammation in mice

Lu, Renhong; Hu, Jiahao; Liu, Xinxin; Yu, Lijiang; Hu, Junjie; Jiang, Huimin; Liu, Shaoyuan; Li, Mengqi; He, Jiakang; Yang, Xiaogan; Liang, Xingwei

doi:10.1039/d2fo02179j

Cited by 12 publications

(5 citation statements)

References 45 publications

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“…Mogroside-rich extracts (MGEs) exhibits the potential to mitigate intestinal impairment resulting from thermal stress by ameliorating the cascades of inflammation and oxidative stress, as indicated by previous investigations ( Lu et al, 2023b ). This finding suggests that MGEs may have the potential to mitigate the consequences of increased thermal stress associated with global climate change.…”

Section: Pharmacological Effectsmentioning

confidence: 84%

A comprehensive review of Siraitia grosvenorii (Swingle) C. Jeffrey: chemical composition, pharmacology, toxicology, status of resources development, and applications

Huang,

Peng,

Zhan

et al. 2024

Front. Pharmacol.

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Siraitia grosvenorii (Swingle) C. Jeffrey (S. grosvenorii), a perennial indigenous liana from the Cucurbitaceae family, has historically played a significant role in southern China’s traditional remedies for various ailments. Its dual classification by the Chinese Ministry of Health for both medicinal and food utility underscores its has the potential of versatile applications. Recent research has shed light on the chemical composition, pharmacological effects, and toxicity of S. grosvenorii. Its active ingredients include triterpenoids, flavonoids, amino acids, volatile oils, polysaccharides, minerals, vitamins, and other microconstituents. Apart from being a natural sweetener, S. grosvenorii has been found to have numerous pharmacological effects, including alleviating cough and phlegm, preventing dental caries, exerting anti-inflammatory and anti-allergic effects, anti-aging and anti-oxidative, hypoglycemic, lipid-lowering, anti-depression, anti-fatigue, anti-schizophrenic, anti-Parkinson, anti-fibrotic, and anti-tumor activities. Despite its versatile potential, there is still a lack of systematic research on S. grosvenorii to date. This paper aims to address this gap by providing an overview of the main active components, pharmacological efficacy, toxicity, current status of development and application, development dilemmas, and strategies for intensive exploitation and utilization of S. grosvenorii. This paper aims to serve as a guide for researchers and practitioners committed to exploiting the biological resources of S. grosvenorii and further exploring its interdisciplinary potential.

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Section: Pharmacological Effectsmentioning

confidence: 84%

A comprehensive review of Siraitia grosvenorii (Swingle) C. Jeffrey: chemical composition, pharmacology, toxicology, status of resources development, and applications

Huang,

Peng,

Zhan

et al. 2024

Front. Pharmacol.

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show abstract

“…No significant effects were noted on body weight, food consumption, hematology, clinical chemistry, organ weights, and histopathological examination (Liu et al., 2017). S. grosvenorii fruit extract could protect against heat stress‐induced intestinal damage by ameliorating inflammation and oxidative stress on normal diet (Lu et al., 2023).…”

Section: Discussionmentioning

confidence: 99%

An Ilex latifolia‐containing compound tea regulates glucose–lipid metabolism and modulates gut microbiota in high‐fat diet‐fed mice

Xu,

Cheng,

Wen

et al. 2024

Food Frontiers

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Kuding Tea (Ilex latifolia) is a bitter‐tasting herbal tea that was used for the treatment of symptoms related with diabetes mellitus, hypertension, and hyperlipidemia. However, Kuding Tea is also difficultly accepted by people in daily life because of its poor palatability. In this study, Kuding Tea, green tea (GT) (Camellia sinensis L.), and Luohan (Siraitia grosvenorii) fruits were formulated into a compound Kuding Tea (CKT) to improve the taste and health benefits of this beverage. High‐fat diet‐fed male C57BL/6J mice were used as animal models to explore the effects of CKT (6 or 12 mg/mL, water ad libitum) on body weight, food intake, liver function, blood glucose and lipids, and gene expression. L02 and 3T3‐L1 cells were used to further demonstrate the effects of CKT on fat accumulation and hepatic lipid deposition. Our results suggest that CKT can regulate glucose and lipid metabolism by decreasing body weight, reducing white adipose deposition, improving glucose tolerance, increasing the expression of brown adipose genes, and reducing fat accumulation in the liver, and CKT inhibited fat accumulation better than GT. In addition, a low dose (6 mg/mL) of CKT reduced the abundance of Desulfovibrio bacteria, positively associated with obesity, and increased that of norank_f__Muribaculaceae, Lachnospiraceae_NK4A136_group, and Alloprevotella, which are beneficial to glucose and lipid metabolism. This study suggests that CKT not only has a better palatability but also has potential preventive effects on high‐fat diet‐induced glucose–lipid metabolic diseases.

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“…For example, berberine inhibits the gene expression of HSP70 and TNF-α by suppressing the binding of the TATAbox binding protein (TBP) to the “TATAbox”, which ultimately leads to a decrease in body temperature [ 64 ]. Mogroside-rich extracts inhibit NF-κB and HSP70 expression, thus protecting against heat-stress-induced intestinal damage by reducing inflammation and oxidative stress [ 86 ]. IL-6 is a pro-inflammatory cytokine that activates the NF-κB pathway, and gintonin-enriched extract can produce antipyretic effects by decreasing the level of IL-6 in muscle cells [ 87 , 88 ].…”

Section: Potential Regulatory Mechanisms Of Plant Extracts In Allevia...mentioning

confidence: 99%

Plant Extracts to Alleviating Heat Stress in Dairy Cows

Guo,

Li,

Yan

et al. 2023

Animals

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Heat stress (HS) in cows is a critical issue in the dairy industry. Dairy cows accumulate heat from body metabolism, along with that imposed by air temperature, humidity, air flow and solar radiation. HS in animals can occur during hot and humid summers when the ambient temperature is extremely high. Dairy cows have relatively high feed intakes and metabolic heat production and are thus susceptible to HS, leading to reductions in feed intake, lower milk yield, affected milk quality, reduced animal health and even shortening the productive lifespan of cows. Therefore, alleviating HS is a top priority for the dairy industry. Suitable plant extracts have advantages in safety, efficiency and few toxic side effects or residues for applications to alleviate HS in dairy cows. This paper reviews the effects of some plant extract products on alleviating HS in dairy cows and briefly discusses their possible mechanisms of action.

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Mogroside-rich extract from Siraitia grosvenorii fruits protects against heat stress-induced intestinal damage by ameliorating oxidative stress and inflammation in mice

Abstract: Global warming makes humans and animals more vulnerable to heat stress. Heat stress can cause multiorgan dysfunction, especially in the intestine, primarily via oxidative stress and inflammation. Mogroside-rich extract (MGE)...

Cited by 12 publications

References 45 publications

A comprehensive review of Siraitia grosvenorii (Swingle) C. Jeffrey: chemical composition, pharmacology, toxicology, status of resources development, and applications

A comprehensive review of Siraitia grosvenorii (Swingle) C. Jeffrey: chemical composition, pharmacology, toxicology, status of resources development, and applications

An Ilex latifolia‐containing compound tea regulates glucose–lipid metabolism and modulates gut microbiota in high‐fat diet‐fed mice

Plant Extracts to Alleviating Heat Stress in Dairy Cows

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