Mogroside V ameliorates broiler pulmonary inflammation via modulating lung microbiota and rectifying Th17/Treg dysregulation in lipopolysaccharides-induced lung injury

Li, Yuan; Shen, Dan; Wang, Kai; Xue, Yufan; Liu, Junze; Li, Sheng; Li, Xiaoqing; Li, Chunmei

doi:10.1016/j.psj.2023.103138

Cited by 3 publications

(2 citation statements)

References 34 publications

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“…Regulatory T (Treg) cells play a crucial role in the immune system by suppressing excessive immune responses and maintaining immune balance. The relationship between Treg cells and lung function ( 49 ), the imbalance of Treg cells during COPD progression ( 50 ), and the potential of modulating Treg cells to improve COPD ( 51 ) and lung inflammation underscore their significance ( 52 ). Myeloid cells, capable of phagocytosing pathogens, initiating inflammatory responses, and presenting antigens to other immune cells, contribute to tissue repair and remodeling.…”

Section: Discussionmentioning

confidence: 99%

Dissecting causal relationships between immune cells, plasma metabolites, and COPD: a mediating Mendelian randomization study

Cao,

Wu,

Fang

et al. 2024

Front. Immunol.

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ObjectiveThis study employed Mendelian Randomization (MR) to investigate the causal relationships among immune cells, COPD, and potential metabolic mediators.MethodsUtilizing summary data from genome-wide association studies, we analyzed 731 immune cell phenotypes, 1,400 plasma metabolites, and COPD. Bidirectional MR analysis was conducted to explore the causal links between immune cells and COPD, complemented by two-step mediation analysis and multivariable MR to identify potential mediating metabolites.ResultsCausal relationships were identified between 41 immune cell phenotypes and COPD, with 6 exhibiting reverse causality. Additionally, 21 metabolites were causally related to COPD. Through two-step MR and multivariable MR analyses, 8 cell phenotypes were found to have causal relationships with COPD mediated by 8 plasma metabolites (including one unidentified), with 1-methylnicotinamide levels showing the highest mediation proportion at 26.4%.ConclusionWe have identified causal relationships between 8 immune cell phenotypes and COPD, mediated by 8 metabolites. These findings contribute to the screening of individuals at high risk for COPD and offer insights into early prevention and the precocious diagnosis of Pre-COPD.

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Section: Discussionmentioning

confidence: 99%

Dissecting causal relationships between immune cells, plasma metabolites, and COPD: a mediating Mendelian randomization study

Cao,

Wu,

Fang

et al. 2024

Front. Immunol.

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“…Importantly, elevated levels of thyroid peroxidase antibody (TPOAb) and thyroglobulin antibody (TGAb) above 60 IU/mL are contributing factors of this condition [2]. In addition, among the various subpopulations of CD4+ T-cells, T helper 17 (Th17) and regulatory T cell (Treg) play crucial roles in maintaining immune homeostasis in the body, despite their contrasting functions [3]. Notably, Th17/Treg imbalance is directly bound up with TPOAb and TgAb [4].…”

Section: Introductionmentioning

confidence: 99%

The relationship of peripheral blood lncRNA-PVT1 and miR-146a levels with Th17/Treg cytokines in patients with Hashimoto’s thyroiditis and their clinical significance

Li,

Shen,

Feng

et al. 2024

Biomol Biomed

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Hashimoto’s thyroiditis (HT) is a prevalent autoimmune disease. We investigated the relationship of peripheral blood long noncoding RNA-plasmacytoma variant translocation 1 (lncRNA-PVT1) and microRNA (miR)-146a levels with Th17/Treg-related cytokines in HT patients and their clinical significance. Correlations of PVT1 and miR-146a with Th17/Treg-related cytokines were analyzed, and its clinical value in diagnosing HT is assessed. Results showed reduced PVT1 and IL-10 levels and increased miR-146a and IL-17 levels in HT patients. PVT1 negatively interrelated with miR-146a, IL-17, IL-23 and IL-6, and positively interrelated with IL-10; miR-146a positively correlated with IL-17, IL-23 and IL-6, but negatively correlated with IL-10 in HT patients. The area under the curve (AUC) of PVT1 and miR-146a levels for diagnosing HT were 0.822 and 0.844, respectively (sensitivity 88.73% and 86.62%, specificity 67.02% and 69.15%, cut-off values 0.76 and 2.73), with their combined detections yielding a higher AUC. Patients with poorly-expressed PVT1 and highly-expressed miR-146a had elevated HT incidence. PVT1 and miR-146a levels were also found to be an independent influencing factor for HT occurrence. Our findings suggest that HT patients have low peripheral blood PVT1 expression and high miR-146a expression. PVT1 and miR-146a level changes were correlated with Th17/Treg cytokine imbalance and could be a potential diagnostic tool and independent influencing factor for HT.

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Screening COPD-Related Biomarkers and Traditional Chinese Medicine Prediction Based on Bioinformatics and Machine Learning

Cao,

Zhao,

et al. 2024

COPD

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Mogroside V ameliorates broiler pulmonary inflammation via modulating lung microbiota and rectifying Th17/Treg dysregulation in lipopolysaccharides-induced lung injury

Cited by 3 publications

References 34 publications

Dissecting causal relationships between immune cells, plasma metabolites, and COPD: a mediating Mendelian randomization study

Dissecting causal relationships between immune cells, plasma metabolites, and COPD: a mediating Mendelian randomization study

The relationship of peripheral blood lncRNA-PVT1 and miR-146a levels with Th17/Treg cytokines in patients with Hashimoto’s thyroiditis and their clinical significance

Screening COPD-Related Biomarkers and Traditional Chinese Medicine Prediction Based on Bioinformatics and Machine Learning

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