It has been observed that post-critically reflected S-waves and multiples from the Moho discontinuity could play a relevant role on the ground motion due to medium to strong size earthquakes away from the source. Although some studies investigated the correlation between the Moho reflections amplitudes and the damage in the far field, little attention was given to the frequency content of these specific phases and their scaling with magnitude. The 2012 Emilia seismic sequence in northern Italy, recorded by velocimetric and accelerometric networks, is here exploited to investigate Moho reflections and multiples (SmSM). A single station method for group velocity-period estimation, based on the multiple filter technique, is applied to strong motion data to detect SmSM. Amplitude and frequency scaling with magnitude is defined for earthquakes from Mw = 3.9 to Mw = 5.9. Finally, the ability of SmSM to affect the ground motion for a maximum credible earthquake within the Po plain is investigated by extrapolating observed engineering parameters. Data analysis shows that high amplitude SmSM can be recognized within the Po plain, and at the boundaries between the Po plain and the Alpine chain, at epicentral distances larger than 80 km, in the period range from 0.25 to 3 s and in the group velocity window from about 2.6 to 3.2 km/s. 5 % damped pseudo-spectral accelerations at different periods (0.3, 1.0 and 2.0 s), and Housner intensities, are obtained from data characterized by large amplitude SmSM. A scaling relationship for both pseudo-spectral accelerations and Housner intensities is found for the earthquakes of the 2012 Emilia seismic sequence. I MCS from VII to VIII is estimated, as a result of SmSM amplitude enhancement, at about 100 km for a maximum credible earthquake (Mw = 6.7) in the Po plain, showing that moderate to high damage cloud be caused by these specific phases.