Mohs Micrographic Surgery is Accurate 95.1% of the Time for Melanoma In Situ: A Prospective Study of 167 Cases

Abstract

MMS is a viable option for treatment of MIS that may increase cure rate and reduce the size of the defect especially in cosmetically and functionally sensitive areas.

Guidelines of care for the management of primary cutaneous melanoma

“…Various techniques to achieve complete histologic margin control have been described including, but not limited to permanent section total peripheral margin control and Mohs micrographic surgery. 49,50,[104][105][106] No prospective randomized data are available to make specific recommendations. However, referral for more exhaustive histologic margin assessment may be considered when extensive subclinical extension is suspected.…”

Surgical margins for melanoma in situ

“…Our recurrence rate of 0.3% is consistent with previously published recurrence rates using Mohs micrographic surgery or staged excision (Table IV). [3][4][5][6][7][24][25][26]38,39 If we add the 12 patients who would not have cleared with the recommended 9-mm margin, then up to 15 patients may have recurred. The maximum projected recurrence rate for 9-mm margins is therefore 1.4%.…”

Treatment options in melanoma in situ: topical and radiation therapy, excision and Mohs surgery

“…Most recently, Bene et al. treated 167 patients with MIS, 116 of which were the LM type, with traditional MMS 63 . The cure rate was 98.6% for patients followed up at 50 months and 98.2% for those followed up at 63 months 63 .…”