Mohs Surgery vs Wide Excision for Atypical Fibroxanthoma: Follow-Up

Zalla, Mark J.; Randle, Henry W.; Brodland, David G.; Davis, Jaime L.; Roenigk, Randall K.

doi:10.1111/j.1524-4725.1997.tb00484.x

Cited by 30 publications

(24 citation statements)

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“…(18) Both excision and MMS are used to treat AFX, with recurrence rates of 8.7% and 0–6.9%, respectively. (15-17, 19) All AFX in our cohort were on the head and neck with males being more commonly affected (84.2%), supporting the previously reported predilection of AFX for the head/neck of males. Fifteen (88%) of our patients were treated by MMS with a recurrence rate of 5% and without metastases.…”

Section: Discussionsupporting

confidence: 90%

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Incidence and Clinical Features of Rare Cutaneous Malignancies in Olmsted County, Minnesota, 2000 to 2010

et al. 2017

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Background The incidence of rare cutaneous malignancies is unknown. Current estimates of rare cutaneous malignancy incidences are based on broad epidemiologic data or single institution experiences, not population-based data. Objective To determine the incidence of several rare non-melanoma skin cancers. Methods & Materials We conducted a retrospective chart review of a population-based cohort between the years 2000 and 2010. Residents of Olmsted County, Minnesota, who were diagnosed with a biopsy-proven non-melanoma skin cancer - excluding basal cell carcinoma and squamous cell carcinoma - were included in this study. The primary outcome was tumor incidence. Additionally, we extracted patient demographics, tumor characteristics, treatment modalities, and outcomes. Results The age- and sex-adjusted incidences per 100,000 persons of multiple rare cutaneous malignancies were: atypical fibroxanthoma (1.8), sebaceous carcinoma (0.8), dermatofibrosarcoma protuberans (0.4), microcystic adnexal carcinoma (0.7), eccrine carcinoma (0.4), eccrine porocarcinoma (0.2), and leiomyosarcoma (0.2). Conclusion We report population-based incidences and clinical characteristics for these rare cutaneous malignancies. The immune status and smoking status of patients and the treatment and outcomes of these tumors are reported. Additional studies in a broader population are needed to further define the epidemiology and outcomes of these malignancies.

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Section: Discussionsupporting

confidence: 90%

“…(12) Depending on the modality of treatment, the recurrence rates range from 0–16%(11, 12, 14-17) but likely 7–9%. (12) Metastatic rate ranges from 0.5–4%.…”

Section: Discussionmentioning

confidence: 99%

Incidence and Clinical Features of Rare Cutaneous Malignancies in Olmsted County, Minnesota, 2000 to 2010

et al. 2017

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“…Two treatment modalities are known: Mohs micrographic surgery and wide local excision [111][112][113][114]. There have been several reports of treatment with Mohs micrographic surgery, which showed a lower local recurrence rate than with excision.…”

Section: Treatment Of Afxmentioning

confidence: 98%

Atypical fibroxanthoma: new insights

Hussein

2014

Expert Review of Anticancer Therapy

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Atypical fibroxanthoma (AFX) is an ultraviolet radiation-associated dermal neoplasm. To address the clinicopathologic and molecular features of this particular neoplasm. The author conducted a literature review using PubMed searching for articles relating to AFX. AFX usually appears as a rapidly growing nodular or nodulo-ulcerative lesion. It occurs on sun-exposed skin of elderly peoples. AFX may be composed predominantly of pleomorphic, spindle, epithelioid cells, or admixture of these cells. The differential diagnosis of AFX includes pleomorphic dermal sarcoma, squamous cell carcinoma, malignant melanoma and leiomyosarcoma. Several observations favor a mesenchymal origin for AFX. These reviews address the clinicopathologic features, molecular pathology, prognosis and treatment of this neoplasm.

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“…Although AFX was traditionally treated with wide local excision, Mohs micrographic surgery has been shown to maximize tissue conservation and result in a lower recurrence rate. [28][29][30] Conclusion AFX is an uncommon spindle cell neoplasm with the potential for local recurrence and, rarely, metastasis. The occurrence of three AFXs in our patient following cardiac transplant and three previously reported cases of AFXs in transplant recipients suggest that this group of patients may be at increased risk of developing AFX.…”

Section: Discussionmentioning

confidence: 99%