Moist heat treatment on physicochemical change of chitosan salt films

Ritthidej, Garnpimol C.; Phaechamud, Thawatchai; Koizumi, Tamotsu

doi:10.1016/s0378-5173(01)00894-8

Cited by 167 publications

(91 citation statements)

References 9 publications

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“…Chitosan acetate exhibited higher moisture content than chitosan citrate and lactate. The results on the weight loss at higher temperatures (at around 150-200°C) were in accordance with earlier findings with chitosan salts (34,38). Based on the weight loss, the chitosan acid salts studied can be ranked in the following descending order: chitosan citrate > chitosan lactate > chitosan acetate.…”

Section: Thermal Properties Of Chitosan Saltssupporting

confidence: 92%

“…Chitosan lactate and citrate salts exhibited a broad second endothermic peak at around 150-200°C, which is attributed to a loss of crystallization water and the melting point of the mixtures. Similar behavior was previously reported to chitosan lactate and citrate microcapsules (38) and films (34). On the other hand, Phaechamud et al suggested that the second endotherm with the chitosan citrate films is obviously related to transition of chitosan citrate from crystalline to amorphous form (39).…”

Section: Fourier Transform Infrared Spectroscopysupporting

confidence: 84%

“…At elevated temperatures, the carboxylic acids may protonate and slowly react with the amine to form an amide (34,36). This amidation decreases the amount of hydrophilic groups and result in lower water sorption (34). In this study, chitosan citrate and chitosan lactate samples were found to have lower moisture content compared with chitosan acetate (Table I).…”

Section: Thermal Properties Of Chitosan Saltsmentioning

confidence: 62%

“…In the case of chitosan citrate (and use of citric acid), this finding can be attributed to the higher number of carboxylic groups in the molecule of citric acid in relation to the molecule of the other two acids employed, thus allowing a greater ionic interaction with chitosan (28,38). At elevated temperatures, the carboxylic acids may protonate and slowly react with the amine to form an amide (34,36). This amidation decreases the amount of hydrophilic groups and result in lower water sorption (34).…”

Section: Thermal Properties Of Chitosan Saltsmentioning

confidence: 99%

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Effects of Spray Drying on Physicochemical Properties of Chitosan Acid Salts

et al. 2011

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Abstract. The effects of spray-drying process and acidic solvent system on physicochemical properties of chitosan salts were investigated. Chitosan used in spray dryings was obtained by deacetylation of chitin from lobster (Panulirus argus) origin. The chitosan acid salts were prepared in a laboratory-scale spray drier, and organic acetic acid, lactic acid, and citric acid were used as solvents in the process. The physicochemical properties of chitosan salts were investigated by means of solid-state CP-MAS 13 C nuclear magnetic resonance (NMR), X-ray powder diffraction (XRPD), differential scanning calorimetry, and Fourier transform infrared spectrometry (FTIR) and near-infrared spectroscopy. The morphology of spray-dried chitosan acid salts showed tendency toward higher sphericity when higher temperatures in a spray-drying process were applied. Analysis by XRPD indicated that all chitosan acid salts studied were amorphous solids. Solid-state 13 C NMR spectra revealed the evidence of the partial conversion of chitosan acetate to chitin and also conversion to acetyl amide form which appears to be dependent on the spray-drying process. The FTIR spectra suggested that the organic acids applied in spray drying may interact with chitosan at the position of amino groups to form chitosan salts. With all three chitosan acid salts, the FTIR bands at 1,597 and 1,615 cm −1 were diminished suggesting that -NH groups are protonated. The FTIR spectra of all chitosan acid salts exhibited ammonium and carboxylate bands at 1,630 and 1,556 cm −1 , respectively. In conclusion, spray drying is a potential method of preparing acid salts from chitosan obtained by deacetylation of chitin from lobster (P. argus) origin.

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Section: Thermal Properties Of Chitosan Saltssupporting

confidence: 92%

Section: Fourier Transform Infrared Spectroscopysupporting

confidence: 84%

Section: Thermal Properties Of Chitosan Saltsmentioning

confidence: 62%

Section: Thermal Properties Of Chitosan Saltsmentioning

confidence: 99%

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Effects of Spray Drying on Physicochemical Properties of Chitosan Acid Salts

et al. 2011

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“…The solvent casting technique was used for the preparation of patches. 16 The gel was cast into a glass petri dish and covered with an inverted funnel, the end of which was plugged with cotton wool to allow controlled evaporation of the solvent. These were left undisturbed at room temperature (20-C-30-C) for 24 hours, till a flexible film was formed.…”

Section: Preparation Of Mucoadhesive Buccal Patchesmentioning

confidence: 99%

Effect of hydrophilic polymers on buccoadhesive eudragit patches of propranolol hydrochloride using factorial design

Patel¹,

Prajapati

Patel

2007

AAPS PharmSciTech

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The purpose of this study was to develop formulations and systematically evaluate in vitro performances of buccoadhesive patches of propranolol hydrochloride using the hydrophobic polymer Eudragit L-100 as the base matrix. The hydrophilic polymers Carbopol 934 and polyvinyl pyrrolidone (PVP) K30 were incorporated into the Eudragit patches, to provide the patches with bioadhesive properties and to modify the rate of drug release. The patches, which were prepared by the solvent casting method, were smooth and elegant in appearance; were uniform in thickness, weight, and drug content; showed no visible cracks; and showed good folding endurance. A 3 2 full factorial design was employed to study the effect of independent variables like hydrophilic polymers Carbopol 934 and PVP K30, which significantly influenced characteristics like swelling index, ex vivo mucoadhesive strength, in vitro drug release, and ex vivo residence time. A stability study of optimized Eudragit patches was done in natural human saliva; it was found that both drug and buccal patches were stable in human saliva. It can be concluded that the present buccal formulation can be an ideal system to improve the bioavailability of the drug by avoiding hepatic first-pass metabolism.

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Chitosan and Chitosan Blends as Antimicrobials

Fernández-Saiz

2011

Antimicrobial Polymers

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Moist heat treatment on physicochemical change of chitosan salt films

Cited by 167 publications

References 9 publications

Effects of Spray Drying on Physicochemical Properties of Chitosan Acid Salts

Effects of Spray Drying on Physicochemical Properties of Chitosan Acid Salts

Effect of hydrophilic polymers on buccoadhesive eudragit patches of propranolol hydrochloride using factorial design

Chitosan and Chitosan Blends as Antimicrobials

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