Moisture-associated skin damage (MASD) occurs when skin is repeatedly exposed to various sources of bodily secretions or effl uents, often leading to irritant contact dermatitis, characterized by infl ammation with or without denudation of affected skin. In 2020, the Wound, Ostomy and Continence Nurses Society commissioned an initiative that led to the addition of multiple International Classifi cation of Diseases, Tenth Revision, Clinical Modifi cation codes ( ICD -10-CM ) for irritant contact dermatitis caused by various forms of MASD for use in the United States. In a recent issue of the Journal of Wound, Ostomy and Continence Nursing , a clinical practice alert identifying the various new codes was published that summarized each of the new codes and provided highlights of the descriptions for each of these codes. This is the second in a series of 2 follow-up articles providing a more detailed description of the MASD conditions to which the newest irritant contact dermatitis ICD-10-CM codes apply. Specifi cally, this article reviews the clinical manifestations and assessment, pathophysiology, epidemiology, prevention, and management of irritant contact dermatitis associated with digestive secretions from a stoma or fi stula, and fecal or urinary effl uent from an abdominal stoma or enterocutaneous fi stula.