To investigate the alleviation potency of coal seam water infusion on coal and gas outburst, this paper focuses on the Qidong coal mine outburst coal seam, where outburst accidents have occurred many times, and obtains the impact of water content on outburst prediction parameters by studying the features of outburst parameters and gas desorption law under different water content rates. How water content affects outburst was also researched through the use of a self-made outburst simulation test system, and the relationship between water content and outburst intensity and critical gas pressure was studied. It can be concluded that with the rise of water content, the initial velocity of gas diffusion, the gas desorption index of drilling cuttings, and the adsorption constant a decrease, but the firmness coefficient (f) increase, and these indicators are exponentially related to the water content. Meanwhile, as the water content raises, the outburst pressure threshold increases, the outburst intensity gradually decreases, and the less likely outburst occurs. Under 0.5 MPa pressure, as the water content arose from 2.02 to 5.14%, the outburst intensity was significantly weakened, while no outburst occurred as the water content reached to 10.25%. Fitting analysis of the influence curve of outburst parameters and comparing the vital values of outburst prediction indexes finally determined that the water content rate of 5.14% could be used as a key index for water injection measures for coal and gas outburst prevention coal seam in Qidong coal mine no. 9. This research offers a guiding significance for the outburst prevention measures of water infusion in outburst coal seams and gives a feasible scheme for the safe mining of outburst coal mines.