Moisture induced solid phase degradation of l-ascorbic acid part 2, separation and characterization of the major degradation products

Shephard, Anthony B; Nichols, Steven C.; Braithwaite, A.

doi:10.1016/s0039-9140(98)00279-3

Cited by 13 publications

(8 citation statements)

References 27 publications

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“…Previous studies have shown μPADs to be stable at room temperature for up to 24 h (Jayawardane et al, 2012). However, beyond this time, the response decreased, presumably due to the acid hydrolysis of ascorbic acid in the reducing layer (Shephard et al, 1999). It is desirable to improve the storage stability of the devices if they are intended for field applications.…”

Section: Results and Discusssionmentioning

confidence: 99%

Evaluation and Application of a Paper-Based Device for the Determination of Reactive Phosphate in Soil Solution

et al. 2014

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The evaluation and validation of a new low-cost microfluidic paper-based analytical device (μPAD) for the determination of reactive phosphate in soil solution is described. This device allows up to 15 replicate measurements of reactive phosphate on one credit card-sized device and requires only a desktop or hand scanner for signal detection and quantification. The proposed method showed a linear response between 0.1 and 1.0 mg L and between 1.0 and 10.0 mg L P with a limit of detection of 0.05 mg L P. When applied to the analysis of soil solution, there was excellent agreement between results obtained using the μPAD and those obtained by a reference spectrophotometric method, as indicated by the following regression equation: [P] = (0.997 ± 0.005)[P] - (0.020 ± 0.008) ( = 0.997; = 110). It was found that the ambient temperature storage stability of the μPAD could be extended to 15 d by incorporating a removable polymeric interleaving sheet between the adjacent paper layers of the device. The observed sensitivity of the μPADs to sunlight, which was manifested by photoreduction of the chromogenic molybdate reagent used in the assay, was overcome by preparing the μPADs with an ultraviolet-filtering laminating material. The proposed method is rapid, with a reaction time of only 10 min, is easy to perform, and is suitable for application in the field.

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Section: Results and Discusssionmentioning

confidence: 99%

Evaluation and Application of a Paper-Based Device for the Determination of Reactive Phosphate in Soil Solution

et al. 2014

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“…Generally, solution state ascorbic acid degradation has been described as the result of oxidation to dehydroascorbic acid followed by subsequent hydrolysis to further end products ,, . Evidence of differences in degradation was provided by Shephard et al with the finding that, unlike in the solution state, furans were not detected during solid phase ascorbic acid degradation. Production of different degradation products could result in alterations to vitamin C stability, depending on the solubility (and thus contribution to deliquescence lowering) of the end products and their impact on the solution pH ,, .…”

Section: Discussionmentioning

confidence: 99%

Influence of Simultaneous Variations in Temperature and Relative Humidity on Chemical Stability of Two Vitamin C Forms and Implications for Shelf Life Models

Hiatt

Taylor

Mauer

2010

J. Agric. Food Chem.

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Vitamin C powder ingredients are popular food fortificants and are among the most commonly added nutrients. While information on degradation kinetics and shelf life of vitamin C exists, current models are limited in their applicability to systems where relative humidity (RH) and temperature are varied simultaneously, and where phase transformations occur. This study monitored stability of two forms of vitamin C (sodium ascorbate and ascorbic acid) under various RH and temperature conditions. Vitamin C was measured colorimetrically, and stability data were used to improve understanding of vitamin C shelf life when deliquescence occurs during storage. RH and temperature both significantly impacted vitamin stability, though RH had a larger effect. Vitamin dissolution preceded extensive degradation and was found to be a good predictor of vitamin C loss. This research highlights the importance of considering phase transformations when constructing shelf life models and maintaining vitamin C in the solid state for enhanced stability.

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“…Weight loss could be due to further decomposition of DHAA breakdown products, with release of CO 2 . [14,26] Compared to dynamic moisture sorption measurements, increasing amounts of N a in binary DHAA:N a mixtures resulted in increased moisture uptake. Weight gain for binary DHAA and N a mixtures after 12 weeks of storage at 98% RH ranged from 141% w/w for a 50:50 ratio to 207% w/w for a 10:90 ratio of DHAA to N a .…”

Section: Weight Gain and Physical Observations During Controlled Rh Smentioning

confidence: 99%

“…[13] In particular, evidence has suggested that solid phase and solution phase ascorbic acid degradation differ, resulting in different end products. [14] Since vitamin mixes may be subjected to varying RH conditions during formulation, processing, packaging, storage, and distribution, an understanding of the impact of watersolid interactions on chemical stability within vitamin C powders is important for ensuring delivery of the vitamins in their primary active forms. The objective of this research was to determine the effect of deliquescence and deliquescence lowering, storage RH conditions, and formulation on the chemical stability of different forms of vitamin C: ascorbic acid (A), sodium ascorbate (N a ), and calcium ascorbate (C a ).…”

Section: Introductionmentioning

confidence: 99%

Deliquescence Behavior and Chemical Stability of Vitamin C Forms (Ascorbic Acid, Sodium Ascorbate, and Calcium Ascorbate) and Blends

Hiatt

Ferruzzi

Taylor

et al. 2011

International Journal of Food Properties

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The stability and type of vitamin C added to foods is important for enhancing product quality, label claims, and shelf-life. To improve understanding of stability, the effects of deliquescence, storage relative humidity (RH) formulation, and addition of ascorbyl palmitate and dehydroascorbic acid on degradation of vitamin C at 25 • C were studied. Individual vitamin C forms (ascorbic acid, sodium, and calcium ascorbate) and mixtures were stored below, near, and above their deliquescence RH for up to 12 weeks. Vitamin C stability was significantly affected by RH and vitamin form (p < 0.0001). Formulation affected deliquescence and chemical stability: mixtures were significantly less stable above RH 0mix than below (p < 0.0001). Ascorbyl palmitate-enhanced degradation rates of more soluble vitamin C forms, and the presence of dehydroascorbic acid reduced vitamin blend stability. It is important that vitamin C products be stored below the deliquescence RH to avoid enhanced vitamin losses.

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Moisture induced solid phase degradation of l-ascorbic acid part 2, separation and characterization of the major degradation products

Cited by 13 publications

References 27 publications

Evaluation and Application of a Paper-Based Device for the Determination of Reactive Phosphate in Soil Solution

Evaluation and Application of a Paper-Based Device for the Determination of Reactive Phosphate in Soil Solution

Influence of Simultaneous Variations in Temperature and Relative Humidity on Chemical Stability of Two Vitamin C Forms and Implications for Shelf Life Models

Deliquescence Behavior and Chemical Stability of Vitamin C Forms (Ascorbic Acid, Sodium Ascorbate, and Calcium Ascorbate) and Blends

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