2017
DOI: 10.4103/0975-7406.206216
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Moisture sorption–desorption characteristics and the corresponding thermodynamic properties of carvedilol phosphate

Abstract: Aims:Carvedilol phosphate (CDP) is a nonselective beta-blocker used for the treatment of heart failures and hypertension. In this work, moisture sorption–desorption characteristics and thermodynamic properties of CDP have been investigated.Materials and Methods:The isotherms were determined using dynamic vapor sorption analyzer at different humidity conditions (0%–90% relative humidity) and three pharmaceutically relevant temperatures (20°C, 30°C, and 40°C). The experimental sorption data determined were fitte… Show more

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Cited by 3 publications
(2 citation statements)
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“…Water sorption and diffusion have been a subject of interest in many different research areas including membrane separation, pharmacology, food packaging and fibres as well as material degradation (Allada et al, 2017;Argyropoulos et al, 2011;Célino et al, 2014;Kohler et al, 2003;Kurokawa, 1981;Kymäläinen et al, 2015;Leão & Tuller, 2014;Zhang et al, 2013). Materials can be affected by the relative humidity (RH) of the environment, which can often cause undesirable changes in mechanical and chemical properties.…”
Section: Introductionmentioning
confidence: 99%
“…Water sorption and diffusion have been a subject of interest in many different research areas including membrane separation, pharmacology, food packaging and fibres as well as material degradation (Allada et al, 2017;Argyropoulos et al, 2011;Célino et al, 2014;Kohler et al, 2003;Kurokawa, 1981;Kymäläinen et al, 2015;Leão & Tuller, 2014;Zhang et al, 2013). Materials can be affected by the relative humidity (RH) of the environment, which can often cause undesirable changes in mechanical and chemical properties.…”
Section: Introductionmentioning
confidence: 99%
“…Hygroscopicity is a physicochemical property of materials which measures the level of interaction between a material and the water molecules present in the surrounding atmosphere. This property describes the ability of materials to absorb or adsorb moisture from the environment to which a material is subjected [36].…”
Section: Hygroscopicitymentioning
confidence: 99%