Molar cusp development in the bat, Hipposideros beatus, with reference to the ontogenetic basis of occlusion

Marshall, Pam; Butler, P. M.

doi:10.1016/0003-9969(66)90197-x

Cited by 28 publications

(13 citation statements)

References 12 publications

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“…BUTLER (1939, p. 3) identified three subfields in the generalized mammalian dentition, which he identified as an "incisivization" field, a "caninization" field, and a "molarization" field. This field concept has been widely applied in studying tooth form (e.g., DAHLBERG, 1945); ontogenetic growth ( VAN VALEN, 1962;MARSHALL • BUTLER, 1966), heritability (ALVESALO & TIGERSTEDT, 1974), and phylogeny (PATTERSON, 1949). In a recent paper on Indriidae, GINGERICH (1977) emphasized the functional aspect of fields in the dentition of mammals, with distinct incisor, canine, and cheek tooth fields functioning, respectively, in food acquisition, in display (and/or food acquisition), and in mastication.…”

Section: Dental Fields--a Discussionmentioning

confidence: 99%

Dental and cranial variation in living Indriidae

Gingerich

Ryan

1979

Primates

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ABSTRACT. Four species of Indriidae are extant in Madagascar. We have studied large samples of each of these to characterize dental and cranial variation, and to estimate the degree of sexual dimorphism in the dentition and cranium. Two dental fields are apparent, characterized by reduced variability: (1) a canine field centered on the upper canine and occluding caniniform lower premolar, and (2) a cheek tooth field centered on the second molars. No consistent pattern of sexual dimorphism was found in dental or cranial dimensions, and we conclude that none of the four species is sexually dimorphic. This lack of dental and cranial dimorphism is unusual in primates, and probably reflects the relatively limited aggressive behavior and the lack of male dominance in Indriidae.

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Section: Dental Fields--a Discussionmentioning

confidence: 99%

Dental and cranial variation in living Indriidae

Gingerich

Ryan

1979

Primates

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“…In other words, in this model pattern formation and morphogenesis are mutually linked, a mechanism that we call here morphodynamic. Additionally, tooth growth (10,11,(20)(21)(22)(23) is biased along the bucco-lingual and anterio-posterior axes, and these biases are implemented as parameters in the model. BMPs expressed in the mesenchyme have been implicated as a source of these biases in vivo (12).…”

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confidence: 99%

A gene network model accounting for development and evolution of mammalian teeth

Salazar‐Ciudad

Jernvall

2002

Proc. Natl. Acad. Sci. U.S.A.

354

294

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Generation of morphological diversity remains a challenge for evolutionary biologists because it is unclear how an ultimately finite number of genes involved in initial pattern formation integrates with morphogenesis. Ideally, models used to search for the simplest developmental principles on how genes produce form should account for both developmental process and evolutionary change. Here we present a model reproducing the morphology of mammalian teeth by integrating experimental data on gene interactions and growth into a morphodynamic mechanism in which developing morphology has a causal role in patterning. The model predicts the course of tooth-shape development in different mammalian species and also reproduces key transitions in evolution. Furthermore, we reproduce the known expression patterns of several genes involved in tooth development and their dynamics over developmental time. Large morphological effects frequently can be achieved by small changes, according to this model, and similar morphologies can be produced by different changes. This finding may be consistent with why predicting the morphological outcomes of molecular experiments is challenging. Nevertheless, models incorporating morphology and gene activity show promise for linking genotypes to phenotypes.

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“…chyme, because the formation of cusps is a product of the folding and growth of this interface (17)(18)(19)(32)(33)(34). As the folding proceeds, the differentiating inner enamel epithelium facing the mesenchyme gives rise to enamel-forming ameloblasts, and the mesenchyme below gives rise to the dentine-forming odontoblasts (17)(18)(19)(32)(33)(34).…”

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confidence: 99%

“…As the folding proceeds, the differentiating inner enamel epithelium facing the mesenchyme gives rise to enamel-forming ameloblasts, and the mesenchyme below gives rise to the dentine-forming odontoblasts (17)(18)(19)(32)(33)(34). Next, to link gene activity to molar crown topography, we used GIS methodologies to analyze changes in the DEMs and correlated these with molecular markers for cusp development.…”

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confidence: 99%

Evolutionary modification of development in mammalian teeth: Quantifying gene expression patterns and topography

Jernvall

Keränen

Thesleff

2000

Proc. Natl. Acad. Sci. U.S.A.

220

143

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The study of mammalian evolution often relies on detailed analysis of dental morphology. For molecular patterning to play a role in dental evolution, gene expression differences should be linkable to corresponding morphological differences. Because teeth, like many other structures, are complex and evolution of new shapes usually involves subtle changes, we have developed topographic methods by using Geographic Information Systems. We investigated how genetic markers for epithelial signaling centers known as enamel knots are associated with evolutionary divergence of molar teeth in two rodent species, mouse and vole. Our analysis of expression patterns of Fgf4, Lef1, p21, and Shh genes in relation to digital elevation models of developing tooth shapes shows that molecular prepatterns predict the lateral cusp topography more than a day in advance. A heterotopic shift in the molecular prepatterns can be implicated in the evolution of mouse molar, changing locations from which historically homologous cusps form. The subtle but measurable heterotopic shifts may play a large role in the evolution of tooth cusp topographies. However, evolutionary increase in the number of longitudinal cusps in vole molar has involved accelerated longitudinal growth and iterative addition of new cusps without changes in lateral cusp topography. The iterative addition of cusps after the establishment of lateral cusp topography may limit the independence of individual morphological features used in evolutionary studies. The diversity of mammalian molar patterns may largely result from the heterotopic and iterative processes.

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Molar cusp development in the bat, Hipposideros beatus, with reference to the ontogenetic basis of occlusion

Cited by 28 publications

References 12 publications

Dental and cranial variation in living Indriidae

Dental and cranial variation in living Indriidae

A gene network model accounting for development and evolution of mammalian teeth

Evolutionary modification of development in mammalian teeth: Quantifying gene expression patterns and topography

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