Molar-Incisor Malformation in a Pediatric Patient on Chemotherapy Treatment

Abstract

ABS TRACT Certain chemotherapeutic agents used for malignancies in early childhood may cause abnormal tooth and root development. The panoramic examination of a patient who received chemotherapy for hepatoblastoma at the age of 18 months showed maxillary and mandibular first molars with clinically normal-looking crowns and insufficient root development, which were diagnosed with molar-incisor malformation (MIM). The review of the patient's medical file revealed that the chemotherapeutic agents causing the root anomaly were the combination of doxorubicin and cisplatin. The aim of this case report is to evaluate the relationship between MIM, and multiple chemotherapeutic agents used in early childhood.