Molecular actions of sex hormones in the brain and their potential treatment use in anxiety disorders

Pillerová, Miriam; Borbélyová, Veronika; Pastorek, Michal; Riljak, V; Hodosy, Július; Frick, Karyn M.; Tóthová, Ľubomíra

doi:10.3389/fpsyt.2022.972158

Cited by 8 publications

(3 citation statements)

References 188 publications

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“…The relationship between corticosterone, depression, and sex hormones is complicated and controversial. Estradiol signaling might involve in regulation of HPA axis through estrogen receptors (Kokras et al., 2020; Pillerová et al., 2022). Molecular studies revealed that estradiol regulates corticotropin‐releasing hormone mRNA expression (Lalmansingh & Uht, 2008).…”

Section: Discussionmentioning

confidence: 99%

Repeated finasteride administration promotes synaptic plasticity and produces antidepressant‐ and anxiolytic‐like effects in female rats

Nayana,

Shankaranarayana Rao,

Srikumar

2024

J of Neuroscience Research

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Finasteride is used in female‐pattern hair loss, hirsutism, and polycystic ovarian syndrome. It inhibits 5α‐reductase, which is an important enzyme in the biosynthesis of neurosteroids. The effects of finasteride treatment on mental health in female patients as well as the effects of repeated/chronic finasteride administration in female rodents are still unknown. Accordingly, in our study, we administered finasteride (10, 30, or 100 mg/Kg, s.c.) for 6 days in female rats and evaluated behavior, plasma steroid levels, and synaptic plasticity. Depression‐like behavior was evaluated using forced swim test (FST) and splash test. Anxiety‐like behavior was evaluated using novelty‐suppressed feeding task (NSFT), elevated plus maze (EPM), open field test (OFT), and light–dark test (LDT). Plasma steroid levels were assessed using ELISA and synaptic plasticity by field potential recordings. We observed that finasteride decreased total immobility duration in FST, indicating antidepressant‐like effect and decreased the latency to first bite in NSFT, showing anxiolytic‐like effect. We also found a significant increase in plasma estradiol and a significant decrease in plasma corticosterone level. Furthermore, field potential recordings showed that finasteride increased hippocampal long‐term potentiation. These results indicate that repeated finasteride administration in female rats may have antidepressant‐ and anxiolytic‐like effect, which might be mediated by enhanced estradiol levels or decreased corticosterone levels. Further studies are required to validate the molecular mechanisms underlying the effects of finasteride in female rats. Understanding the mechanisms will help us in developing novel neurosteroid‐based therapeutics in the treatment of neuropsychiatric disorders in women.

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Section: Discussionmentioning

confidence: 99%

Repeated finasteride administration promotes synaptic plasticity and produces antidepressant‐ and anxiolytic‐like effects in female rats

Nayana,

Shankaranarayana Rao,

Srikumar

2024

J of Neuroscience Research

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“…In contrast, men have testosterone hormone with an anxiolytic effect by reducing stress responses and suppressing the Hypothalamic-Pituitary-Adrenal (HPA) axis activity. 27 This explains why gonadal hormones play a role in women's higher prevalence of anxiety levels. Fluctuations in estrogenic and progesterone during the menstrual cycle affect the reactivation of the HPA axis and feedback response to glucocorticoids and Gamma-aminobutyric acid (GABA), resulting in a less stable hormonal balance than in men, contributing to anxiety.…”

Section: Discussionmentioning

confidence: 99%

Anxiety and depression in family caregivers of hemodialysis patients: Incidence, risk factors, and correlation

Osman,

Susanti,

Estiko

et al. 2023

JKKI

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Background: Chronic kidney disease (CKD) imposes a significant global burden, with diabetes and hypertension being major contributors. In the severe stage, CKD patients require long-term hemodialysis (HD) treatment and rely on family caregivers for support. Caregivers often experience mental health challenges, including anxiety and depression, which can impact their quality of life and patient outcomes.Objective: This study aimed to identify the anxiety and depression incidence in HD family caregivers at Soehadi Prijonegoro Regional Public Hospital (SPRPH), identify the risk factors associated with these conditions, and investigate the relationship between anxiety and depressionMethods: A cross-sectional analysis was carried out at the Hemodialysis Department from November 2022 to February 2023. Caregivers accompanying CKD patients undergoing HD participated voluntarily. Anxiety and depression levels were evaluated using the Hamilton Anxiety Rating Scale (HAM-A) and Hamilton Depression Rating Scale (HAM-D). Results: Out of 106 participants, 66% were female. Most caregivers (99%) experienced anxiety, with 91% classified as mild and 8% as mild to moderate. Depression was reported by 42%, with 2% experiencing mild to moderate symptoms. Spearman’s analysis revealed a significant correlation between anxiety and depression (p=0.000). No specific caregiver characteristics were found to be associated with anxiety or depression.Conclusion: Family caregivers of HD patients demonstrated a high incidence of anxiety and a lower prevalence of depression. Anxiety levels were correlated with depression levels. We did not identify specific risk factors for these mental health conditions among caregivers. These findings emphasize the need for mental health screening and appropriate management to improve the quality of life for HD family caregivers.

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“…In the brain, the sex steroid hormone has activating and organizational effects mediated by intracellular or transmembrane G-protein-coupled receptors. (35) It is important to study the relationship between steroid hormones with aging and cognitive function. Previously it was mentioned that the aging process is associated with changes in hormone levels (18,19) ; as a result, these hormone levels reduce several body functions, including cognitive function.…”

Section: Sex Steroid Hormone and Cognitive Function In The Elderlymentioning

confidence: 99%

Role of sex steroid hormone on hand grip strength and cognitive function in the elderly

Parwanto,

Tjahyadi,

Amalia

et al. 2023

Univ Med

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The aging process is associated with changes in hormone levels. There is a noticeable change in estrogen levels in women, while in men, there is a change in testosterone levels. In the elderly, as a result of the aging process, changes in these hormone levels affect handgrip strength, and cognitive function. In both women and men, the function of several organs is influenced by sex steroid hormones, namely Oestrogen and androgens. There are two theories of steroid action mechanism on target cells, namely steroid hormone action mechanism genomically and non-genomically. The function and action mechanism of steroid hormone is important because it is the basis of the hormonal aspect for muscle mass, handgrip strength, and cognitive function. Due to the aging process, hormonal changes in the elderly are different compared to the previous period. This has consequences for changes in metabolic processes that affect the body’s condition, including changes in the composition of bones, muscles, and other tissues, such as the brain. In the aging process, it is important to pay attention to nutritional factors because they contribute to hormone levels that help maintain muscle mass, body mass index, hand grip strength, and cognitive function. In the brain, the sex steroid hormone has activating and organizational effects mediated by intracellular or transmembrane G-protein-coupled receptors. Articles published in English in the last 9 years (from 2014 to 2023) were retrieved from Science Direct, PubMed, Springer link, Oxford and Nature using relevant searching terms. The fact that testosterone bioavailability is predominated in the brain in relation to its activity and significant positive association with processing speed, sustained attention, and working memory in older men. To obtain a better quality of life for the elderly, nutritional factors must be considered to maintain optimal sex steroid hormone levels, hand grip strength, and cognitive function.

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Molecular actions of sex hormones in the brain and their potential treatment use in anxiety disorders

Cited by 8 publications

References 188 publications

Repeated finasteride administration promotes synaptic plasticity and produces antidepressant‐ and anxiolytic‐like effects in female rats

Repeated finasteride administration promotes synaptic plasticity and produces antidepressant‐ and anxiolytic‐like effects in female rats

Anxiety and depression in family caregivers of hemodialysis patients: Incidence, risk factors, and correlation

Role of sex steroid hormone on hand grip strength and cognitive function in the elderly

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