Molecular advances in pancreatic cancer: A genomic, proteomic and metabolomic approach

Rajesh, Srujan; Cox, Michael J.; Runau, Franscois

doi:10.3748/wjg.v27.i31.5171

Cited by 5 publications

(5 citation statements)

References 32 publications

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Section: Discussionmentioning

confidence: 99%

“…Work in genomics, proteomics, and metabolomics to identify resistance or susceptibility to chemotherapy drugs has the potential to maximize treatment benefits and minimize treatment-related toxicity. 37 One of the drawbacks to NACRT is its toxicity and potential to delay curative surgery, especially in patients who have resectable disease. Both FOLFIRINOX and gemcitabine are toxic, and comparisons of their toxicities vary in their results.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Neoadjuvant Treatment Versus Upfront Surgery in Resectable Pancreatic Cancer: A Cost-Effectiveness Analysis

Arjani

Prasath

Suri

et al. 2023

JCO Oncology Practice

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PURPOSE: Pancreatic cancer (PC) has an overall 5-year survival rate of 10%. The use of neoadjuvant chemoradiation is debated in resectable disease. The purpose of this study is to evaluate the cost-effectiveness of neoadjuvant chemoradiation followed by pancreaticoduodenectomy (NACRT) versus upfront pancreaticoduodenectomy and adjuvant chemotherapy (USR) in resectable PC. METHODS: A decision tree model was used to estimate the cost-effectiveness of NACRT versus USR. Values from the published literature populate the tree: costs from Medicare (FY2021) reimbursements, and morbidity and survival data for quality-adjusted life-years (QALYs). Patients with resectable pancreatic adenocarcinoma who qualified for resection were included. The ICER was the primary outcome. The model was validated using one-way and two‐way deterministic, as well as probabilistic sensitivity analyses. RESULTS: The base case was modeled using a 65-year-old male. NACRT yielded 1.61 QALYs at $45,483.52 USD. USR yielded 1.47 QALYs at a discount of $6,840.96 USD. The ICER was $48,130 USD, which favors NACRT. One-way sensitivity analyses upheld these results except when ≤ 21.0% of NACRT patients proceeded to surgery and when ≤ 85.4% of NACRT patients were resectable at surgery. Two-way sensitivity analyses also favored NACRT except in cases when the proportion of resected disease after NACRT decreased. NACRT was favored in 94.3% of 100,000 random-sampling simulations. CONCLUSION: It is more cost-effective to administer NACRT before surgery for patients with resectable PC. On the basis of sensitivity analyses, USR with adjuvant therapy is only favored if rates of resection and eligibility for resection after NACRT decrease. NACRT should be considered in all patients unless there is an absolute contraindication.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Neoadjuvant Treatment Versus Upfront Surgery in Resectable Pancreatic Cancer: A Cost-Effectiveness Analysis

Arjani

Prasath

Suri

et al. 2023

JCO Oncology Practice

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“…Nonetheless, little is still known about the tumorigenesis of PDAC in these individuals [ 83 ]. Whole genome sequencing studies may help to understand the carcinogenesis of these interval cases [ 84 ].…”

Section: Outcomes Of High-risk Individuals Undergoing Pancreatic Canc...mentioning

confidence: 99%

Aspects and outcomes of surveillance for individuals at high-risk of pancreatic cancer

Bogdanski,

van Hooft,

Boekestijn

et al. 2024

Familial Cancer

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Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer-related deaths and is associated with a poor prognosis. The majority of these cancers are detected at a late stage, contributing to the bad prognosis. This underscores the need for novel, enhanced early detection strategies to improve the outcomes. While population-based screening is not recommended due to the relatively low incidence of PDAC, surveillance is recommended for individuals at high risk for PDAC due to their increased incidence of the disease. However, the outcomes of pancreatic cancer surveillance in high-risk individuals are not sorted out yet. In this review, we will address the identification of individuals at high risk for PDAC, discuss the objectives and targets of surveillance, outline how surveillance programs are organized, summarize the outcomes of high-risk individuals undergoing pancreatic cancer surveillance, and conclude with a future perspective on pancreatic cancer surveillance and novel developments.

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“…The molecules that the omics studied give it the name: metabolomics, proteomics, metabolomics, genomics, etc. (Rajesh et al, 2021).…”

Section: Omics: Understanding the Biological Systemsmentioning

confidence: 99%

CIERMMI Women in Science T-XVIII Health Sciences

MARROQUÍN-DE JESÚS,

MORALES-HERNÁNDEZ,

RAMÍREZ-BALTAZAR

et al. 2022

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The Colegio de Ingenieros en Energías Renovables de Querétaro A.C. (CIER-QUERÉTARO), and its chapters of Renewable Energy, Industrial Maintenance, Mechatronics and Informatics, technical sponsors of the International Interdisciplinary Congress on Renewable Energy, Maintenance, Mechatronics and Informatics, CIERMMI 2022 has as general objective to establish a space for discussion and reflection on issues related to the areas of: renewable energy, industrial maintenance, mechatronics and informatics with the participation of students, teachers, researchers and national and international speakers, promoting the formation and consolidation of research networks. Contributing to provide a space for dissemination and discussion of the presentations of students, graduates, academics and researchers, representatives of various higher education institutions, research centers in our country, as well as educational institutions beyond our borders. Promoting the formation of research networks between different institutions. Offering a space for undergraduate, master's, doctoral and postdoctoral students, in which they can present the progress of the research they carry out in their different educational centers. Providing a space in which study groups and members of academic bodies, linked to the curricular program of renewable energy, industrial maintenance, mechatronics and computer science careers, can present the research work developed within their institution and in collaboration with other national or international educational institutions. Establishing a training space for the attendees, through the development of specific lectures and conferences. This volume, Women in Science T-XVIII-2022 contains 8 refereed chapters dealing with these issues, chosen from among the contributions, we gathered some researchers and graduate students from the 32 states of our country. We thank the reviewers for their feedback that contributed greatly in improving the book chapters for publication in these proceedings by reviewing the manuscripts that were submitted. CARDENAS, ALTAMIRANO, ARREOLA and RESÉNDEZ introduce the Modelling of human polyglutamine neurological disorders in Drosophila, DÍAZ, GONZÁLEZ, UVALLE and MEDEROS analyse the association between triglycerides and insulin resistance as a predictor of cardiometabolic diseases in university students; REYES, ROMERO, MIGUEL and FERNANDEZ present the use of medicinal plants by dentists in the state of Guerrero, Mexico; MERAZ, HERNÁNDEZ, GARCÍA and CÁRDENAS are investigating the association between sleep quality and executive functions in a sample of first-semester medical students at a public university; VALLEJO, ROJAS, VERDUGO and LIMON welcome us to the omics era: proteomics importance in cancer research; CERÓN, CERÓN, LARA and VICHIQUE submit diurnal variation and health risk of atmospheric aromatic hydrocarbons concentrations in an urban site located in Nuevo Leon, Mexico; QUITL & JIMÉNEZ expose mental health and family dynamics in university students from Tlaxcala after confinement. Finally, SALGADO, AGUILAR, CRUZ and CÉLIS study the effects of a training program for fitness instructors based on STD and BPN on the attitude of users of a private university gym.

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Molecular advances in pancreatic cancer: A genomic, proteomic and metabolomic approach

Cited by 5 publications

References 32 publications

Neoadjuvant Treatment Versus Upfront Surgery in Resectable Pancreatic Cancer: A Cost-Effectiveness Analysis

Neoadjuvant Treatment Versus Upfront Surgery in Resectable Pancreatic Cancer: A Cost-Effectiveness Analysis

Aspects and outcomes of surveillance for individuals at high-risk of pancreatic cancer

CIERMMI Women in Science T-XVIII Health Sciences

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