Molecular Allergen Profiling of Dual Mite Sensitization in Severe Allergic Rhinitis

González‐Pérez, Ruperto; Pineda, Fernando; Poza‐Guedes, Paloma; Castillo, Miriam; Matheu, Víctor; Sánchez‐Machín, Inmaculada

doi:10.18176/jiaci.0439

Cited by 25 publications

(32 citation statements)

References 43 publications

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“…Mono-sensitization to Der p 23 was as low as 3% and also comparable to Weghofer et al [12] showing that 4% of patients were mono-sensitized to Der p 23. Also, González-Pérez et al [13] reported a mono-sensitization of 3% towards Der p 23 in Spain. Although mono-sensitization seems to be a rare event, Matos Semedo et al [24] argue that Der p 23 itself has clinical relevance and should probably be considered in terms of HDM-specific immunotherapy extract composition.…”

Section: Discussion/conclusionmentioning

confidence: 97%

“…The aim of the study was to investigate the prevalence of IgE reactivity to Der p 23 in a relatively large sample of patients in southern Bavaria based on the evidence that Der p 23 could be a major allergen of HDM, as already published for other regions [9,10,[12][13][14][15]. According to the result patients were separated in patients with allergic symptoms to house dust mite (n = 67) and patients with clinically silent sensitization (n = 50) (a as ratio with total serum IgE, p = 8.867, b as ratio with sIgE to D.…”

Section: Discussion/conclusionmentioning

confidence: 99%

“…Celi et al [9] reported a much lower sensitization rate of 60% for Der p 23 in Italy (n = 519). A recent study from Tenerife, Spain, reported a prevalence of 80% Der p 23 sensitivity in 59 patients with severe allergic rhinitis [13]. In a Thai cohort, only 54% of 222 patients with HDM-related allergic rhinitis or asthma showed sIgE reactivity to Der p 23 [14].…”

Section: Introductionmentioning

confidence: 97%

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The Role of Der p 23 Sensitization: An Analysis of 474 Patients Sensitized to Mite

Eder

Becker

Gellrich

et al. 2020

Int Arch Allergy Immunol

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Introduction: House dust mite contains several allergen components and causes perennial allergy. Lately, a new major allergen, Der p 23, was described with relatively high sensitization rates in different European Countries. In addition, Der p 23 is supposed to cause asthmatic disease. Objective: We would like to question the prevalence and clinical impact of specific immunoglobulin E to Der p 23 in a large patient sample in southern Bavaria, Germany. Methods: 474 patients from southern Bavaria, who visited the allergy department within the Department of Oto-Rhino-Laryngology of a university hospital, with sensitization to Dermatophagoides pteronyssinus were retrospectively compared regarding their sensitization profile to Der p 1, Der p 2, and Der p 23 and their clinical characteristics. Results: Among D. pteronyssinus-sensitized patients, the overall sensitization rate to Der p 23 was 42% in southern Bavaria. Most likely, patients were simultaneously sensitized to Der p 1, Der p 2, and Der p 23. Der p 23-sensitized patients reported more frequently asthma and showed higher prevalence of poly-sensitization towards 3 additional allergen groups and higher prevalence of double-sensitization to Der p 1 and Der p 2 compared to patients with missing sensitization to Der p 23. Considering the results of allergen provocation tests, neither IgE sensitization against Der p 23 nor levels of specific immunoglobulin E to Der p 23 allow a clear prediction of the clinical relevance of the sensitization. Conclusion: With a sensitization rate of 42%, Der p 23 closely misses the criterion of a major allergen in our southern Bavarian patient collective. A higher prevalence of polysensitization and self-reported asthma was the only clinical feature found in Der p 23-sensitized patients.

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Section: Discussion/conclusionmentioning

confidence: 97%

Section: Discussion/conclusionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

See 1 more Smart Citation

The Role of Der p 23 Sensitization: An Analysis of 474 Patients Sensitized to Mite

Eder

Becker

Gellrich

et al. 2020

Int Arch Allergy Immunol

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“…In the past decades, lots of studies have been focused on common allergens testing in the specific populations [6][7][8]. There are different allergen sensitizaton patterns in various regions.…”

Section: Introductionmentioning

confidence: 99%

Prevalence and distribution patterns of allergens among children with asthma and asthma-like symptoms in Shanghai, China

Mao

Shi

2020

Respir Res

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Objective: We aimed to identify the prevalence and distribution patterns of allergens among Chinese children with asthma/asthma-like symptoms (ALS). Methods: A total of 3479 children with asthma/ALS were enrolled. Skin prick test (SPT) was used to test the allergen-specific IgE. We analysed allergens prevalence and distribution, and its relationship with demographic characteristics. Results: Aeroallergens prevalence was higher than that of food allergens (p < 10 − 4 ). Boys had higher aeroallergens prevalence than that in girls (p < 10 − 4 ). Significant difference of aeroallergens prevalence among cases with different parental allergy history was observed (p < 10 − 4 ). Age was positively associated with aeroallergens prevalence before the age of 11.5 (P < 10 − 4 ), particularly before the age of 2.42 (P < 10 − 4 ). Age was negatively associated with aeroallergens prevalence after the age of 11.5 (P = 0.021). Age was negatively associated with food allergens prevalence before the age of 3.42 (P < 10 − 4 ). Age was associated with the intensity of dermatophagoides farinae (DF)/house dust mite (HDM) allergens (P < 10 − 4 ). Age was negatively associated with the intensity of shrimp, and crab allergens before the age of 3.3 and 3.3, respectively (P = 0.012, < 10 − 4 ). Boys had higher intensity of DF and HDM allergens than that in girls (P < 10 − 4 , P < 10 − 4 ). Significant differences of the intensity of DF and HDM allergens among groups with different parental allergy history were noted (P < 10 − 4 , P < 10 − 4 ). Conclusions:Boys and parental allergy history were associated with higher prevalence and intenstity of aeroallergens. Age was positively and negatively associated with aeroallergens prevalence before and after the age of 11.5, respectively. Age was negatively associated with food allergens prevalence before the age of 3.42.

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“…Despite the high prevalence of sIgE response to Der p 23, only 2 subjects (2.17%) were exclusively sensitized to Der p 23 in our sample. The high prevalence (>85%) of Der p 23 sIgE confirmed the importance of this allergen component as a major HDM allergen supported by former research from Austria [41], Thailand [42], and Spain [43]. Batard et al [44] equally reported that in temperate regions, 20–47% of 1,302 HDM allergic patients also showed sIgE to allergens from groups 4, 5, 7, 13, 15, 21, and 23.…”

Section: Discussionmentioning

confidence: 67%

Mite Molecular Profile in the Th2-Polarized Moderate-to-Severe Persistent Asthma Endotype Subjected to High Allergen Exposure

González‐Pérez

Poza‐Guedes

Pineda

et al. 2020

Int Arch Allergy Immunol

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Background: The association among the IgE responses to prevailing groups of house dust mite (HDM) allergens in the concurrent asthma phenotypes has not been determined. Objective: The aim of the present study lays on a component-resolved diagnosis (CRD) model to investigate the mite molecular signature in subjects with type-2 inflammation asthma. Methods: We selected patients showing a clinically relevant sensitization to HDMs with moderate-to-severe persistent asthma. Skin prick test (SPT) with standardized mite extracts, a broad customized CRD serum sIgE panel including 9 Dermatophagoides pteronyssinus allergens and the related protein allergenic characterization, was investigated in all serum samples. Results: Ninety out of 93 (96.77%) patients with a positive SPT to HDM showed a concordant sIgE (≥0.35 kUA/L) to the crude extract of D. pteronyssinus. Major allergens (Der p 2, Der p 23, and Der p 1) were present in >70% of all subjects, with mid-tier allergens (Der p 5, Der p 7, and Der p 21) reaching up to 51% in the present cohort. A complex pleomorphic repertoire of HDM molecules recognized by IgE was depicted, including 38 distinct profiles. Conclusions and Clinical Relevance: The proposed CRD panel approach, containing the most prevalent HDM allergens, appeared to be sufficient to obtain a precise D. pteronyssinus molecular diagnosis in asthmatics with a climate-dependent high-mite allergen exposure and coexisting sensitization. A dominant role of both major and mid-tier allergens has been confirmed in moderate and severe persistent asthmatics with the preponderant Th2-high endotype.

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Molecular Allergen Profiling of Dual Mite Sensitization in Severe Allergic Rhinitis

Abstract: This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as

Cited by 25 publications

References 43 publications

The Role of Der p 23 Sensitization: An Analysis of 474 Patients Sensitized to Mite

The Role of Der p 23 Sensitization: An Analysis of 474 Patients Sensitized to Mite

Prevalence and distribution patterns of allergens among children with asthma and asthma-like symptoms in Shanghai, China

Mite Molecular Profile in the Th2-Polarized Moderate-to-Severe Persistent Asthma Endotype Subjected to High Allergen Exposure

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