Molecular allergology approach to allergic asthma

Agache, Ioana; Palmer, Elizabeth; Sanver, Didem; Kirtland, Max; Shamji, Mohamed H.

doi:10.1016/j.mam.2021.101027

Cited by 13 publications

(7 citation statements)

References 124 publications

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“…Asthma is a chronic respiratory disease characterized by airway inflammation and hyperresponsiveness 46 . Observational studies have provided evidence suggesting that the consumption of vegetable-based foods may delay the onset of asthma 47 .…”

Section: Discussionmentioning

confidence: 99%

Mendelian randomization study reveals the relationship between dietary factors and respiratory diseases

Lai,

Li,

Peng

et al. 2023

Sci Rep

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The existence of causal relationship between dietary factors and respiratory diseases is uncertain. We comprehensively investigated the association between dietary factors and respiratory diseases by using Mendelian randomization (MR). Genetic variants linked to dietary factors were selected as instrumental variables with genome-wide significance. These instrumental variables were obtained from large GWAS databases. These databases include Biobank, the FinnGen study, and other large consortia. We used multivariate MR analyses to control the effects of smoking and education. Median analysis was conducted to evaluate whether body mass index (BMI) played a role in dietary factors in respiratory diseases. Dried fruit intake was found to be associated with a decreased risk of chronic obstructive pulmonary disease (COPD) (OR: 0.211; 95% CI 0.117–0.378; P < 0.001) and asthma (OR: 0.539; 95% CI 0.357–0.815; P = 0.003). Conversely, pork intake was associated with an increased risk of international pharmaceutical federation (IPF) (OR: 1.051*102, 95% CI 4.354–2.56*103, P = 0.004). However, no significant associations were observed between the 20 dietary factors and obstructive sleep apnea (OSA). In addition, multivariate MR analyses showed that the above results were unchanged in smoking and nonsmoking populations, while the effect of dried fruit intake on asthma was significantly attenuated after corrective education. The results of the mediator variable analysis indicated that BMI could serve as a mediator of the above results. This study found that dried fruits slowed the progression of COPD and asthma, while pork promoted IPF. However, no effect of dietary factors on OSA was found. Meanwhile, we showed that the above results were unchanged in smoking and non-smoking populations. In contrast, education could influence the role of diet on asthma, and BMI could be used as a mediating variable to influence the above results.

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Section: Discussionmentioning

confidence: 99%

Mendelian randomization study reveals the relationship between dietary factors and respiratory diseases

Lai,

Li,

Peng

et al. 2023

Sci Rep

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“…Some traditional Chinese medicines have been discovered to have a protective effect on asthma by regulating certain PCD pathways, but their particular targets and mechanisms are unclear, which restricts the use of these drugs in clinical asthma treatment (Table 2). Following these conclusions, we make some suggestions for future research: (1) The study of PCD in asthma should be more in-depth and specific. For example, the study of apoptosis in asthma has been specific to various cells, and different types of cells have different effects on asthma, which may be advantageous or detrimental.…”

Section: Discussionmentioning

confidence: 82%

“…The classical pyrolytic pathway is mediated by the assembly of inflammasomes and depends on Caspase-1. Most inflammasomes comprise three components: (1) Receptor proteins, such as NLRP1, NLRP3, NLRC4, AIM2, and pyrin, of which NLRP3 is the most researched. (2) The adaptor protein ASC, contains CARD.…”

Section: Pyroptosismentioning

confidence: 99%

Programmed Cell Death in Asthma: Apoptosis, Autophagy, Pyroptosis, Ferroptosis, and Necroptosis

Lü¹,

Zhou²,

Wang³

et al. 2023

JIR

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Bronchial asthma is a complex heterogeneous airway disease, which has emerged as a global health issue. A comprehensive understanding of the different molecular mechanisms of bronchial asthma may be an efficient means to improve its clinical efficacy in the future. Increasing research evidence indicates that some types of programmed cell death (PCD), including apoptosis, autophagy, pyroptosis, ferroptosis, and necroptosis, contributed to asthma pathogenesis, and may become new targets for future asthma treatment. This review briefly discusses the molecular mechanism and signaling pathway of these forms of PCD focuses on summarizing their roles in the pathogenesis and treatment strategies of asthma and offers some efficient means to improve clinical efficacy of therapeutics for asthma in the near future.

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“…Asthma is the most prevalent chronic respiratory illness, with allergic asthma being the most frequent kind, which is often defined by environmental allergens and it is characterized by bronchospasm and inflammatory infiltration ( 145 ). Allergic asthma has a far younger average age of start than other forms of asthma, accounting for over 90% of asthma cases in children and half of asthma cases in adults ( 146 ).…”

Section: Allergic Diseasementioning

confidence: 99%

Macrophage polarization: an important role in inflammatory diseases

Luo,

Zhao,

Cheng

et al. 2024

Front. Immunol.

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Macrophages are crucial cells in the human body’s innate immunity and are engaged in a variety of non-inflammatory reactions. Macrophages can develop into two kinds when stimulated by distinct internal environments: pro-inflammatory M1-like macrophages and anti-inflammatory M2-type macrophages. During inflammation, the two kinds of macrophages are activated alternatively, and maintaining a reasonably steady ratio is critical for maintaining homeostasis in vivo. M1 macrophages can induce inflammation, but M2 macrophages suppress it. The imbalance between the two kinds of macrophages will have a significant impact on the illness process. As a result, there are an increasing number of research being conducted on relieving or curing illnesses by altering the amount of macrophages. This review summarizes the role of macrophage polarization in various inflammatory diseases, including autoimmune diseases (RA, EAE, MS, AIH, IBD, CD), allergic diseases (allergic rhinitis, allergic dermatitis, allergic asthma), atherosclerosis, obesity and type 2 diabetes, metabolic homeostasis, and the compounds or drugs that have been discovered or applied to the treatment of these diseases by targeting macrophage polarization.

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Molecular allergology approach to allergic asthma

Cited by 13 publications

References 124 publications

Mendelian randomization study reveals the relationship between dietary factors and respiratory diseases

Mendelian randomization study reveals the relationship between dietary factors and respiratory diseases

Programmed Cell Death in Asthma: Apoptosis, Autophagy, Pyroptosis, Ferroptosis, and Necroptosis

Macrophage polarization: an important role in inflammatory diseases

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