Molecular alterations in metaphase chromosomes induced by bleomycin

Urbańska, Marta; Sofińska, Kamila; Czaja, Michał; Szymoński, Krzysztof; Skirlińska-Nosek, Katarzyna; Seweryn, Sara; Lupa, Dawid; Szymoński, Marek; Lipiec, Ewelina

doi:10.1016/j.saa.2024.124026

Spectrochimica Acta Part A: Molecular and Biomolecular Spectros

2024

DOI: 10.1016/j.saa.2024.124026

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Molecular alterations in metaphase chromosomes induced by bleomycin

Marta Urbańska,

Kamila Sofińska,

Michał Czaja

et al.

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2024

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Multiplexed molecular imaging identifies pancreatic cancer candidates for epigenetic modulators

Szymonski,

Janiszewska,

Sofińska

et al. 2024

Preprint

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Genomic alterations drive the tumorigenesis of pancreatic cancer (PC). However, alone they do not explain its numerous phenotypes. Exploring the epigenetic landscapes of PC delivers a more insightful picture and might reveal excellent targeted therapies that could improve patient survival. PC subtyping based on histological features reflects its morphological diversity and correlates with clinical outcomes. Here we used a label-free multiplexed molecular imaging to recognize PC epigenetic modifications spatially, consequently, DNA and histone methylation (at lysine and arginine) and histone acetylation (at lysine) were investigated. To complete the picture, B-to-Z-DNA conformational change was assessed. We utilized convolutional neural networks and other machine learning approaches to analyze and semi-quantify the relative variability of epigenome among the six most common PC histological subtypes. We found foamy-glands (FG) and squamous-differentiated (SD) presenting oppositely to others and more alike the benign controls. They consistently expressed higher global levels of epigenetic modifications and higher Z-DNA ratios. Overall, our results suggest variable efficacy of targeting epigenetic regulators in histologically distinct PC subtypes.

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Multiplexed molecular imaging identifies pancreatic cancer candidates for epigenetic modulators

Szymonski,

Janiszewska,

Sofińska

et al. 2024

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

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Molecular alterations in metaphase chromosomes induced by bleomycin

Cited by 1 publication

References 53 publications

Multiplexed molecular imaging identifies pancreatic cancer candidates for epigenetic modulators

Multiplexed molecular imaging identifies pancreatic cancer candidates for epigenetic modulators

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