2021
DOI: 10.35401/2500-0268-2021-23-3-19-23
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Molecular alterations in the culture of lung cancer cells H1299 after exposure to high doses of ionizing radiation

Abstract: Objective To study the copy number of genes-components of signaling cascades involved in DNA repair, cell cycle regulation and apoptosis under the influence of high doses of ionizing radiation.Material and Мethods The study was carried out on a culture of H1299 non-small cell lung cancer cells. Cell lines were cultured in a Binder incubator (Germany) for 24 h (at 37 °C, 5% CO2 ), and then the groups were divided into therapeutic and control. The first one was irradiated with a NovalisTx, Varian linear accelera… Show more

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