Molecular alterations that precede the establishment of the hallmarks of cancer: An approach on the prevention of hepatocarcinogenesis

Alarcón-Sánchez, Brisa Rodope; Pérez‐Carreón, Julio Isael; Villa‐Treviño, Saúl; Arellanes‐Robledo, Jaime

doi:10.1016/j.bcp.2021.114818

Cited by 5 publications

(3 citation statements)

References 228 publications

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“…HCC and oxidative stress: Hepatocarcinogenesis is a complex multistep mechanism of the initiation, promotion, and progression of cellular, molecular, and genetic alterations in a certain tumor microenvironment, with oxidative stress as an established trigger and driver [79]. In obesity-related HCC, different ROS-mediated pathways have been associated with carcinogenesis.…”

Section: Oxidative Stress and Hepatocellular Carcinoma (Hcc)mentioning

confidence: 99%

Iron, Oxidative Stress, and Metabolic Dysfunction—Associated Steatotic Liver Disease

Gensluckner,

Wernly,

Datz

et al. 2024

Antioxidants

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Excess free iron is a substrate for the formation of reactive oxygen species (ROS), thereby augmenting oxidative stress. Oxidative stress is a well-established cause of organ damage in the liver, the main site of iron storage. Ferroptosis, an iron-dependent mechanism of regulated cell death, has recently been gaining attention in the development of organ damage and the progression of liver disease. We therefore summarize the main mechanisms of iron metabolism, its close connection to oxidative stress and ferroptosis, and its particular relevance to disease mechanisms in metabolic-dysfunction-associated fatty liver disease and potential targets for therapy from a clinical perspective.

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Section: Oxidative Stress and Hepatocellular Carcinoma (Hcc)mentioning

confidence: 99%

Iron, Oxidative Stress, and Metabolic Dysfunction—Associated Steatotic Liver Disease

Gensluckner,

Wernly,

Datz

et al. 2024

Antioxidants

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“…Identification of molecular signatures that contribute uniformly among cancers is a significant gateway into rapid diagnosis and a more accurate prognosis. The dynamic nature of cancer onset and progression is orchestrated by a series of molecular changes that drive its unique behavior; identification and evaluation of biomarkers contributes significantly to understanding the cellular behavior of cancer cells in isolation and in concert [14,15]. These biomarkers could fall under several categories-they can be genomic, transcriptomic, or epigenomic components that function to regulate or direct carcinogenic transformation [16].…”

Section: Introductionmentioning

confidence: 99%

Long Non-Coding RNAs as Determinants of Thyroid Cancer Phenotypes: Investigating Differential Gene Expression Patterns and Novel Biomarker Discovery

DeSouza,

Jarboe,

Carnazza

et al. 2024

Biology

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Thyroid Cancer (TC) is the most common endocrine malignancy, with increasing incidence globally. Papillary thyroid cancer (PTC), a differentiated form of TC, accounts for approximately 90% of TC and occurs predominantly in women of childbearing age. Although responsive to current treatments, recurrence of PTC by middle age is common and is much more refractive to treatment. Undifferentiated TC, particularly anaplastic thyroid cancer (ATC), is the most aggressive TC subtype, characterized by it being resistant and unresponsive to all therapeutic and surgical interventions. Further, ATC is one of the most aggressive and lethal malignancies across all cancer types. Despite the differences in therapeutic needs in differentiated vs. undifferentiated TC subtypes, there is a critical unmet need for the identification of molecular biomarkers that can aid in early diagnosis, prognosis, and actionable therapeutic targets for intervention. Advances in the field of cancer genomics have enabled for the elucidation of differential gene expression patterns between tumors and healthy tissue. A novel category of molecules, known as non-coding RNAs, can themselves be differentially expressed, and extensively contribute to the up- and downregulation of protein coding genes, serving as master orchestrators of regulated and dysregulated gene expression patterns. These non-coding RNAs have been identified for their roles in driving carcinogenic patterns at various stages of tumor development and have become attractive targets for study. The identification of specific genes that are differentially expressed can give insight into mechanisms that drive carcinogenic patterns, filling the gaps of deciphering molecular and cellular processes that modulate TC subtypes, outside of well-known driver mutations.

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“…As such, these unmet clinical needs provide motivation to develop novel non-invasive tools for early detection and tracking of malignancies. Recent multi-omics studies have offered solid and conclusive evidence that molecular alterations of the genome, transcriptome, proteome and metabolome precede symptom onset [ 13 , 14 , 15 , 16 ]. Moreover, these molecular substances derived from abnormal cells and other microenvironment factors, such as immune cells, can be actively released into the extracellular space and further into body fluids (e.g., blood) in soluble, membrane-bound or -encapsulated forms, proving rich clues for disease occurrence and evolution [ 17 , 18 , 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

Single-Particle Optical Imaging for Ultrasensitive Bioanalysis

Liu

et al. 2022

Biosensors

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The quantitative detection of critical biomolecules and in particular low-abundance biomarkers in biofluids is crucial for early-stage diagnosis and management but remains a challenge largely owing to the insufficient sensitivity of existing ensemble-sensing methods. The single-particle imaging technique has emerged as an important tool to analyze ultralow-abundance biomolecules by engineering and exploiting the distinct physical and chemical property of individual luminescent particles. In this review, we focus and survey the latest advances in single-particle optical imaging (OSPI) for ultrasensitive bioanalysis pertaining to basic biological studies and clinical applications. We first introduce state-of-the-art OSPI techniques, including fluorescence, surface-enhanced Raman scattering, electrochemiluminescence, and dark-field scattering, with emphasis on the contributions of various metal and nonmetal nano-labels to the improvement of the signal-to-noise ratio. During the discussion of individual techniques, we also highlight their applications in spatial–temporal measurement of key biomarkers such as proteins, nucleic acids and extracellular vesicles with single-entity sensitivity. To that end, we discuss the current challenges and prospective trends of single-particle optical-imaging-based bioanalysis.

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Molecular alterations that precede the establishment of the hallmarks of cancer: An approach on the prevention of hepatocarcinogenesis

Cited by 5 publications

References 228 publications

Iron, Oxidative Stress, and Metabolic Dysfunction—Associated Steatotic Liver Disease

Iron, Oxidative Stress, and Metabolic Dysfunction—Associated Steatotic Liver Disease

Long Non-Coding RNAs as Determinants of Thyroid Cancer Phenotypes: Investigating Differential Gene Expression Patterns and Novel Biomarker Discovery

Single-Particle Optical Imaging for Ultrasensitive Bioanalysis

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