Molecular analysis of excised valves in the diagnosis of blood culture negative infective endocarditis (BCNE) in a Cardiac Surgery Referral Center in Rio de Janeiro, Brazil: 1998 to 2009

Lamas, Cristiane da Cruz; Ramos, Rosana Grandelle; Lopes, G.Q.; Golebiovski, W.; Santos, Marisa; Weksler, Clara; Ferrauioli, G.D.; Lépidi, Hubert; Fournier, Pierre‐Edouard; Raoult, Didier

doi:10.1016/j.ijid.2010.02.1552

Cited by 1 publication

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Of these seven patients, only one had the agent identified: Streptococcus oralis group and S. gallolyticus (cross-amplification was likely). This was part of another project in INC 17 . Bartonella and Coxiella serologies are not routinely performed in our center and were not performed for any of the patients in this study.…”

Section: Resultsmentioning

confidence: 99%

“…These are not exactly comparable data, but can be used to extrapolate some information on HCA-IE in Brazil. The proportion of prosthetic valves affected varies from 11.8% to 45.5% in published HCA-IE series and is 43% in ours 4 , 5 , 11 , 17 , 20 - 23 . Despite the number of prosthetic valves involved, the rate of early PVE in our institution is within the one described by the literature 24 .…”

Section: Discussionmentioning

confidence: 99%

“…As part of a PCR study of valves between 1998 and 2009 in collaboration with the Unite' des Rickettsies (Marseille, France), some patients in the present study had their valves analyzed for several pathogens, and only one of 11 valves was positive for S. oralis/S. gallolyticus 17 . Bartonella and Coxiella serologies are not routinely performed in our center, and they are not relevant for HCA-IE.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Healthcare-Associated Infective Endocarditis: Case Series in Referral Hospital from 2006 to 2011

Francischetto¹,

Silva²,

Senna³

et al. 2014

Arquivos Brasileiros De Cardiologia

View full text Add to dashboard Cite

BackgroundHealthcare-associated infective endocarditis (HCA-IE), a severe complication of medical care, shows a growing incidence in literature.ObjectiveTo evaluate epidemiology, etiology, risk factors for acquisition, complications, surgical treatment, and outcome of HCA-IE.MethodsObservational prospective case series study (2006-2011) in a public hospital in Rio de Janeiro.ResultsFifty-three patients with HCA-IE from a total of 151 cases of infective endocarditis (IE) were included. There were 26 (49%) males (mean age of 47 ± 18.7 years), 27 (51%) females (mean age of 42 ± 20.1 years). IE was acute in 37 (70%) cases and subacute in 16 (30%) cases. The mitral valve was affected in 19 (36%) patients and the aortic valve in 12 (36%); prosthetic valves were affected in 23 (43%) patients and native valves in 30 (57%). Deep intravenous access was used in 43 (81%) cases. Negative blood cultures were observed in 11 (21%) patients, Enterococcus faecalis in 10 (19%), Staphylococcus aureus in 9 (17%), and Candida sp. in 7 (13%). Fever was present in 49 (92%) patients, splenomegaly in 12 (23%), new regurgitation murmur in 31 (58%), and elevated C-reactive protein in 44/53 (83%). Echocardiograms showed major criteria in 46 (87%) patients, and 34 (64%) patients were submitted to cardiac surgery. Overall mortality was 17/53 (32%).ConclusionIn Brazil HCA-IE affected young subjects. Patients with prosthetic and native valves were affected in a similar proportion, and non-cardiac surgery was an infrequent predisposing factor, whereas intravenous access was a common one. S. aureus was significantly frequent in native valve HCA-IE, and overall mortality was high.

show abstract

Section: Resultsmentioning

confidence: 99%