Molecular analysis of <scp>HLA</scp> Class I and Class <scp>II</scp> genes in five different South Indian linguistic groups

Seshasubramanian, Vani; SathishKannan, Aruna Devi; Naganathan, Chandramouleeswaran; Narayan, Saranya; Periathiruvadi, Srinivasan

doi:10.1111/tan.14219

Cited by 3 publications

(2 citation statements)

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“…A 2018 study with data obtained from donated cord blood units at Jeevan identifies certain inherited haplotypes (set of genetic determinants inherited from both parents) 13 frequencies in the Tamil-speaking population (Narayan, 2018 ). A recent study proposes a link between South Indian language groups (Malayalam, Urdu, Kannada, Telugu, and Tamil) and finding donors for patients based in Sri Lanka (Seshasubramanian et al, 2021 ). Hegde mathematically posits the link between HLA and language and proves the relationship using Nei's genetic distance formula.…”

Section: Methodsmentioning

confidence: 99%

Thalassemia, biobanking infrastructures, and personalized stem cell therapies in Chennai

Panwar¹

2023

Front. Sociol.

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Thalassemia and leukemia and related blood disorders are approved for blood stem cell transplants in India, for a stem cell transplant to be successful, the human leukocyte antigen (HLA) complex located on the arm of chromosome six must be a match between the cord blood donor and the recipient. In the quest to find an exact blood stem cell match for an individual, the HLA becomes the node at the center of community genetics where the HLA match is sought (not necessarily successful) in the extended family, the same caste, language, and ethnic (both national and the diaspora) groups. By considering thalassemia as a case study, how do we understand personalized stem cell therapies within biobanking infrastructures in Chennai? How do social categories get entwined with biological materials like cord blood?

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Section: Methodsmentioning

confidence: 99%

Thalassemia, biobanking infrastructures, and personalized stem cell therapies in Chennai

Panwar¹

2023

Front. Sociol.

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“…A 2018 study with data obtained from donated cord blood units at Jeevan identifies certain inherited haplotypes (set of genetic determinants inherited from both parents) frequencies in the Tamil-speaking population (Narayan, 2018). A recent study proposes a link between South Indian language groups (Malayalam, Urdu, Kannada, Telugu, and Tamil) and finding donors for patients based in Sri Lanka (Seshasubramanian et al, 2021). Hegde mathematically posits the link between HLA and language and proves the relationship using Nei's genetic distance formula.…”

Section: Figurementioning

confidence: 99%

Personalized Health and Precision Medicine in Practice

2024

Frontiers Research Topics

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Frontiers is more than just an open access publisher of scholarly articles: it is a pioneering approach to the world of academia, radically improving the way scholarly research is managed. The grand vision of Frontiers is a world where all people have an equal opportunity to seek, share and generate knowledge. Frontiers provides immediate and permanent online open access to all its publications, but this alone is not enough to realize our grand goals. Frontiers journal seriesThe Frontiers journal series is a multi-tier and interdisciplinary set of openaccess, online journals, promising a paradigm shift from the current review, selection and dissemination processes in academic publishing. All Frontiers journals are driven by researchers for researchers; therefore, they constitute a service to the scholarly community. At the same time, the Frontiers journal series operates on a revolutionary invention, the tiered publishing system, initially addressing specific communities of scholars, and gradually climbing up to broader public understanding, thus serving the interests of the lay society, too. Dedication to qualityEach Frontiers article is a landmark of the highest quality, thanks to genuinely collaborative interactions between authors and review editors, who include some of the world's best academicians. Research must be certified by peers before entering a stream of knowledge that may eventually reach the public -and shape society; therefore, Frontiers only applies the most rigorous and unbiased reviews. Frontiers revolutionizes research publishing by freely delivering the most outstanding research, evaluated with no bias from both the academic and social point of view. By applying the most advanced information technologies, Frontiers is catapulting scholarly publishing into a new generation. What are Frontiers Research Topics?Frontiers Research Topics are very popular trademarks of the Frontiers journals series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area.

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Prevalence of Human Leukocyte Antigen Alleles Polymorphism in North Indian Population

Yadav,

Prasad,

Kushwaha

et al. 2024

IJN

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Background Human leukocyte antigens (HLA) are highly polymorphic glycoproteins required for immune response and recognizing self or non-self. Knowing the HLA diversity in a population may be helpful in the selection of organ allocation for transplantation. We aimed to retrospectively analyze the prevalence of HLA, A, B, C, DRB1, and DQA1 alleles frequency in the north Indian population. Materials and Methods HLA antigen allele data were retrospectively analyzed from a transplant cohort of 2259 subjects. HLA-A, B, and DRB1 frequency were determined in 2259, HLA-C in 759 and DQA1 in 751 subjects. Results The most abundant HLA-A antigen alleles were HLA-A*01(25.41%), HLA-A*02 (24.83%), HLA-A*11 (17.53%), HLA-A*24 (10.27%), HLA-A*03 (9.07%). HLA-B antigen alleles were HLA-B*35 (20.54%), HLA-B*15 (15.36%), HLA-B*40 (13.59%), HLA-B*07 (10.14%), HLA-B*44 (7.79). HLA-C antigen alleles were HLA-C*07 (28.06%), HLA-C*04 (20.42%), HLA-C*03 (15.55%), HLA-C*06 (13.04%), HLA-C*12 (5.27%). HLA-DRB1 alleles were HLA-DRB1*07 (21.60%), HLA-DRB1*04 (19.74%), HLA-DRB1*10 (13.15%), HLA-DRB1*03 (10.80%), HLA-DRB1*11 (8.63%). HLA-DQA1 antigen alleles were HLA-DQA1*03 (35.42%), HLA-DQA1*02 (30.89%), HLA-DQA1*05 (21.84%), HLA-DQA1* 06 (10.12%), HLA-DQA1*04 (1.07%). Conclusion The most frequent HLA alleles were HLA-A*01(25.41%), HLA-B*35 (20.54%), HLA-C*07 (28.06%), HLA-DRB1*07(21.60%), HLA-DQA1*03(35.42%) in north Indian population.

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Molecular analysis of HLA Class I and Class II genes in five different South Indian linguistic groups

Cited by 3 publications

References 34 publications

Thalassemia, biobanking infrastructures, and personalized stem cell therapies in Chennai

Thalassemia, biobanking infrastructures, and personalized stem cell therapies in Chennai

Personalized Health and Precision Medicine in Practice

Prevalence of Human Leukocyte Antigen Alleles Polymorphism in North Indian Population

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