2013
DOI: 10.1097/cad.0b013e32836009d7
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Molecular analysis of the inhibitory effect of N-acetyl-L-cysteine on the proliferation and invasiveness of pancreatic cancer cells

Abstract: Preliminary studies have suggested that the reactive oxygen species (ROS) scavenger N-acetyl-L-cysteine (NAC) may be effective in inhibiting the growth of pancreatic cancer cells. In-depth cellular and molecular analyses were carried out to determine NAC's mode of action in inhibiting the growth of a well-characterized pancreatic cancer cell line (AsPC-1). Standardized assays were used to monitor cellular growth, apoptosis, levels of ROS, cellular senescence, migration, and invasiveness. Cell stiffness was mea… Show more

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Cited by 10 publications
(2 citation statements)
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“…Therefore, changes in actin structure have the ability to directly affect cell migration [47], [65], [66]. ROS are also known to actively participate in each of the above events [67]–[69]. Since MWCNT significantly induces the generation of ROS and actin expression, it is of interest to evaluate the effects of MWCNT on cell migration.…”
Section: Discussionmentioning
confidence: 99%
“…Therefore, changes in actin structure have the ability to directly affect cell migration [47], [65], [66]. ROS are also known to actively participate in each of the above events [67]–[69]. Since MWCNT significantly induces the generation of ROS and actin expression, it is of interest to evaluate the effects of MWCNT on cell migration.…”
Section: Discussionmentioning
confidence: 99%
“…Stable expression of extracellular SOD (EcSOD) inhibited the ability of BxPC3 pancreatic cancer cells to form tumor xenografts in athymic nude mice and also prolonged their survival [97]. N-acetylcysteine (NAC), an antioxidant which is a precursor of glutathione, blocks KRas-induced ADM [27], but also inhibits the growth and invasiveness of pancreatic cancer cells [126,127]. MitoQ, a mitochondria-targeted antioxidant can block ADM and PanIN formation [27].…”
Section: Targeting Ros In Pda Development and Progressionmentioning
confidence: 99%